# Spatial and temporal regularization to estimate COVID-19 reproduction number R(t): Promoting piecewise smoothness via convex optimization

> Research article (PLoS ONE, 2020) · cited 28× · AI/ML

**Wikidata**: [openalex:W3080432235](https://www.wikidata.org/wiki/openalex:W3080432235)  
**Source**: https://4ort.xyz/entity/spatial-and-temporal-regularization-to-estimate-covid-19-reproduction-number-r-t-promoting-piecewise-smoothness-via-conv