# Spastin

> mammalian protein found in Homo sapiens

**Wikidata**: [Q2308016](https://www.wikidata.org/wiki/Q2308016)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/Spastin)  
**Source**: https://4ort.xyz/entity/spastin


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q9UBP0)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBP0)
5. [Recognition of C-terminal amino acids in tubulin by pore loops in Spastin is important for microtubule severing](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBP0)
6. [GOA](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q9UBP0)
7. [Graded Control of Microtubule Severing by Tubulin Glutamylation](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q9UBP0)
8. [Human spastin has multiple microtubule-related functions](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q9UBP0)
9. [Linking axonal degeneration to microtubule remodeling by Spastin-mediated microtubule severing](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q9UBP0)
10. [Recognition of C-terminal amino acids in tubulin by pore loops in Spastin is important for microtubule severing](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q9UBP0)
11. [The nucleotide cycle of spastin correlates with its microtubule‐binding properties](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q9UBP0)
12. [SPG20 protein spartin is recruited to midbodies by ESCRT-III protein Ist1 and participates in cytokinesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBP0)
13. [Interaction of two hereditary spastic paraplegia gene products, spastin and atlastin, suggests a common pathway for axonal maintenance](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBP0)
14. [Protrudin binds atlastins and endoplasmic reticulum-shaping proteins and regulates network formation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBP0)
15. [Structural basis for midbody targeting of spastin by the ESCRT-III protein CHMP1B](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBP0)
16. [Spastin and ESCRT-III coordinate mitotic spindle disassembly and nuclear envelope sealing](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBP0)
17. [Hereditary spastic paraplegia proteins REEP1, spastin, and atlastin-1 coordinate microtubule interactions with the tubular ER network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBP0)
18. [Graded Control of Microtubule Severing by Tubulin Glutamylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBP0)
19. [Linking axonal degeneration to microtubule remodeling by Spastin-mediated microtubule severing](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBP0)
20. [The nucleotide cycle of spastin correlates with its microtubule‐binding properties](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBP0)
21. [Human spastin has multiple microtubule-related functions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBP0)
22. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBP0)
23. [LEM2 recruits CHMP7 for ESCRT-mediated nuclear envelope closure in fission yeast and human cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBP0)
24. [Spastin subcellular localization is regulated through usage of different translation start sites and active export from the nucleus](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBP0)
25. [Spastin couples microtubule severing to membrane traffic in completion of cytokinesis and secretion](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBP0)
26. [Cellular distribution and subcellular localization of spatacsin and spastizin, two proteins involved in hereditary spastic paraplegia](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBP0)
27. [Cortical constriction during abscission involves helices of ESCRT-III-dependent filaments](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBP0)
28. [Large-scale proteomics and phosphoproteomics of urinary exosomes](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q9UBP0)
29. [Spastin subcellular localization is regulated through usage of different translation start sites and active export from the nucleus](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q9UBP0)
30. [Spastin couples microtubule severing to membrane traffic in completion of cytokinesis and secretion](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q9UBP0)
31. [Spastin and ESCRT-III coordinate mitotic spindle disassembly and nuclear envelope sealing](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q9UBP0)
32. [Protrudin binds atlastins and endoplasmic reticulum-shaping proteins and regulates network formation](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q9UBP0)
33. [Large-scale proteomics and phosphoproteomics of urinary exosomes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBP0)
34. [Cortical constriction during abscission involves helices of ESCRT-III-dependent filaments](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q9UBP0)
35. Ensembl Release 99
36. Transporter Classification database