# SP100 nuclear antigen

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21096399](https://www.wikidata.org/wiki/Q21096399)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/Sp100_nuclear_antigen)  
**Source**: https://4ort.xyz/entity/sp100-nuclear-antigen


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P23497)
3. Q20641742
4. [Differential role of Sp100 isoforms in interferon-mediated repression of herpes simplex virus type 1 immediate-early protein expression](http://www.ebi.ac.uk/QuickGO/annotations?protein=P23497&geneProductId=UniProtKB:P23497)
5. [SP100 expression modulates ETS1 transcriptional activity and inhibits cell invasion](http://www.ebi.ac.uk/QuickGO/annotations?protein=P23497&geneProductId=UniProtKB:P23497)
6. [Chromatin components as part of a putative transcriptional repressing complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23497)
7. [The mammalian heterochromatin protein 1 binds diverse nuclear proteins through a common motif that targets the chromoshadow domain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23497)
8. [Pooled-matrix protein interaction screens using Barcode Fusion Genetics](http://www.ebi.ac.uk/QuickGO/annotations?protein=P23497&geneProductId=UniProtKB:P23497)
9. [Chromatin components as part of a putative transcriptional repressing complex](http://www.ebi.ac.uk/QuickGO/annotations?protein=P23497&geneProductId=UniProtKB:P23497)
10. [Interaction of SP100 with HP1 proteins: a link between the promyelocytic leukemia-associated nuclear bodies and the chromatin compartment](http://www.ebi.ac.uk/QuickGO/annotations?protein=P23497&geneProductId=UniProtKB:P23497)
11. [Sp100 is important for the stimulatory effect of homeodomain-interacting protein kinase-2 on p53-dependent gene expression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23497)
12. [Mediation of Epstein-Barr virus EBNA-LP transcriptional coactivation by Sp100](http://www.ebi.ac.uk/QuickGO/annotations?protein=P23497&geneProductId=UniProtKB:P23497)
13. [Sp100 is important for the stimulatory effect of homeodomain-interacting protein kinase-2 on p53-dependent gene expression](http://www.ebi.ac.uk/QuickGO/annotations?protein=P23497&geneProductId=UniProtKB:P23497)
14. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23497)
15. [Sp100 interacts with ETS-1 and stimulates its transcriptional activity](http://www.ebi.ac.uk/QuickGO/annotations?protein=P23497&geneProductId=UniProtKB:P23497)
16. [Recruitment of NBS1 into PML oncogenic domains via interaction with SP100 protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23497)
17. [SUMO5, a Novel Poly-SUMO Isoform, Regulates PML Nuclear Bodies.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23497)
18. [FLASH links the CD95 signaling pathway to the cell nucleus and nuclear bodies](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23497)
19. [Towards a proteome-scale map of the human protein–protein interaction network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23497)
20. [A proteome-scale map of the human interactome network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23497)
21. [Distinct and overlapping sets of SUMO-1 and SUMO-2 target proteins revealed by quantitative proteomics](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23497)
22. [SP100 expression modulates ETS1 transcriptional activity and inhibits cell invasion](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23497)
23. [Human Cytomegalovirus Infection Causes Degradation of Sp100 Proteins That Suppress Viral Gene Expression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23497)
24. [A census of human transcription factors: function, expression and evolution](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23497)
25. [Interaction of SP100 with HP1 proteins: a link between the promyelocytic leukemia-associated nuclear bodies and the chromatin compartment](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23497)
26. [Common properties of nuclear body protein SP100 and TIF1alpha chromatin factor: role of SUMO modification](http://www.ebi.ac.uk/QuickGO/annotations?protein=P23497&geneProductId=UniProtKB:P23497)
27. [Splice variants of the nuclear dot-associated Sp100 protein contain homologies to HMG-1 and a human nuclear phosphoprotein-box motif](http://www.ebi.ac.uk/QuickGO/annotations?protein=P23497&geneProductId=UniProtKB:P23497)
28. [Dynamic regulation of p53 subnuclear localization and senescence by MORC3](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23497)
29. [The interferon (IFN)-stimulated gene Sp100 promoter contains an IFN-gamma activation site and an imperfect IFN-stimulated response element which mediate type I IFN inducibility](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23497)
30. [Cellular Localization, Expression, and Structure of the Nuclear Dot Protein 52](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23497)
31. [Suppression of alternative lengthening of telomeres by Sp100-mediated sequestration of the MRE11/RAD50/NBS1 complex.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23497)
32. [Evidence for Covalent Modification of the Nuclear Dot–associated Proteins PML and Sp100 by PIC1/SUMO-1](http://www.ebi.ac.uk/QuickGO/annotations?protein=P23497&geneProductId=UniProtKB:P23497)
33. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P23497&geneProductId=UniProtKB:P23497)
34. [SP100 inhibits ETS1 activity in primary endothelial cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23497)
35. Ensembl Release 99
36. [Identifiers.org](https://registry.identifiers.org/registry/uniprot)