# Sp1 transcription factor

> mammalian protein found in Homo sapiens

**Wikidata**: [Q4049840](https://www.wikidata.org/wiki/Q4049840)  
**Source**: https://4ort.xyz/entity/sp1-transcription-factor-q4049840


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P08047)
3. Q20641742
4. Freebase Data Dumps. 2013
5. [Interaction between the two ubiquitously expressed transcription factors NF-Y and Sp1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08047)
6. [The high-mobility-group domain of Sox proteins interacts with DNA-binding domains of many transcription factors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08047)
7. [A functional variant in NKX3.1 associated with prostate cancer susceptibility down-regulates NKX3.1 expression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08047)
8. [GATA-4 and GATA-6 modulate tissue-specific transcription of the human gene for P450c17 by direct interaction with Sp1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08047)
9. [HDAC4 represses p21(WAF1/Cip1) expression in human cancer cells through a Sp1-dependent, p53-independent mechanism](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08047)
10. [Differential distribution of unmodified and phosphorylated histone deacetylase 2 in chromatin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08047)
11. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08047)
12. [Specificity protein-1 as a critical regulator of human cystathionine gamma-lyase in smooth muscle cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=P08047&geneProductId=UniProtKB:P08047)
13. [Human Sug1/p45 is involved in the proteasome-dependent degradation of Sp1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08047)
14. [Complementary quantitative proteomics reveals that transcription factor AP-4 mediates E-box-dependent complex formation for transcriptional repression of HDM2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08047)
15. [POZ domain transcription factor, FBI-1, represses transcription of ADH5/FDH by interacting with the zinc finger and interfering with DNA binding activity of Sp1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08047)
16. [MCAF mediates MBD1-dependent transcriptional repression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08047)
17. [Tau promoter confers neuronal specificity and binds Sp1 and AP-2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08047)
18. [ZBP-89 represses vimentin gene transcription by interacting with the transcriptional activator, Sp1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08047)
19. [Cloning of an intrinsic human TFIID subunit that interacts with multiple transcriptional activators](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08047)
20. [Human BAHD1 promotes heterochromatic gene silencing](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08047)
21. [A set of proteins interacting with transcription factor Sp1 identified in a two-hybrid screening](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08047)
22. [Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08047)
23. [Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08047)
24. [AML1-ETO interacts with Sp1 and antagonizes Sp1 transactivity through RUNT domain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08047)
25. [The phosphorylation status of PAS-B distinguishes HIF-1alpha from HIF-2alpha in NBS1 repression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08047)
26. [Homeodomain protein DLX4 counteracts key transcriptional control mechanisms of the TGF-β cytostatic program and blocks the antiproliferative effect of TGF-β](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08047)
27. [Wild-type p53 controls cell motility and invasion by dual regulation of MET expression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08047)
28. [Novel role of signal transducer and activator of transcription 3 as a progesterone receptor coactivator in breast cancer](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08047)
29. [ZBTB2 increases PDK4 expression by transcriptional repression of RelA/p65](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08047)
30. [A human MAP kinase interactome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08047)
31. [Che-1 arrests human colon carcinoma cell proliferation by displacing HDAC1 from the p21WAF1/CIP1 promoter](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08047)
32. [O-GlcNAc modification of Sp1 inhibits the functional interaction between Sp1 and Oct1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08047)
33. [Functional Synergy between the Transcription Factor Sp1 and the Estrogen Receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08047)
34. [Interaction of Sp1 with the growth- and cell cycle-regulated transcription factor E2F](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08047)
35. [Bidirectional autoregulatory mechanism of metastasis-associated protein 1-alternative reading frame pathway in oncogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08047)
36. [Activation of tissue transglutaminase transcription by histone deacetylase inhibition as a therapeutic approach for Myc oncogenesis.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08047)
37. [HIF-2alpha promotes hypoxic cell proliferation by enhancing c-myc transcriptional activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08047)
38. [Interaction of GATA-3/T-bet transcription factors regulates expression of sialyl Lewis X homing receptors on Th1/Th2 lymphocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08047)
39. [SH2B1β Interacts with STAT3 and Enhances Fibroblast Growth Factor 1-Induced Gene Expression during Neuronal Differentiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08047)
40. [The role of Sp1 and AP-2 in basal and protein kinase A--induced expression of mitochondrial serine:pyruvate aminotransferase in hepatocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08047)
41. [Co-operative interactions between NFAT (nuclear factor of activated T cells) c1 and the zinc finger transcription factors Sp1/Sp3 and Egr-1 regulate MT1-MMP (membrane type 1 matrix metalloproteinase) transcription by glomerular mesangial cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08047)
42. [Reciprocal regulation of expression of the human adenosine 5'-triphosphate binding cassette, sub-family A, transporter 2 (ABCA2) promoter by the early growth response-1 (EGR-1) and Sp-family transcription factors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08047)
43. [Identification of heterogeneous nuclear ribonucleoprotein K as a transactivator for human low density lipoprotein receptor gene transcription](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08047)
44. [A metabolic enzyme of the short-chain dehydrogenase/reductase superfamily may moonlight in the nucleus as a repressor of promoter activity](http://www.ebi.ac.uk/QuickGO/annotations?protein=P08047&geneProductId=UniProtKB:P08047)
45. [A metabolic enzyme of the short-chain dehydrogenase/reductase superfamily may moonlight in the nucleus as a repressor of promoter activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08047)
46. [Specificity protein-1 as a critical regulator of human cystathionine gamma-lyase in smooth muscle cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08047)
47. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P08047&geneProductId=UniProtKB:P08047)
48. [A census of human transcription factors: function, expression and evolution](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08047)
49. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08047)
50. [Cooperation of Sp1 and p300 in the induction of the CDK inhibitor p21WAF1/CIP1 during NGF-mediated neuronal differentiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08047)