# SOS Ras/Rac guanine nucleotide exchange factor 1

> mammalian protein found in Mus musculus

**Wikidata**: [Q14908125](https://www.wikidata.org/wiki/Q14908125)  
**Source**: https://4ort.xyz/entity/sos-ras-rac-guanine-nucleotide-exchange-factor-1


## References

1. UniProt
2. Q20641742
3. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62245)
4. [An effector region in Eps8 is responsible for the activation of the Rac-specific GEF activity of Sos-1 and for the proper localization of the Rac-based actin-polymerizing machine](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62245)
5. [The tyrosine phosphatase PTP1C associates with Vav, Grb2, and mSos1 in hematopoietic cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62245)
6. [Interchangeability of Themis1 and Themis2 in Thymocyte Development Reveals Two Related Proteins with Conserved Molecular Function](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62245)
7. [A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62245)
8. [Efficient suppression of FGF-2-induced ERK activation by the cooperative interaction among mammalian Sprouty isoforms](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62245)
9. [Oligomerization of signaling complexes by the multipoint binding of GRB2 to both LAT and SOS1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62245)
10. [Disabled-2 (Dab2) is an SH3 domain-binding partner of Grb2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62245)
11. [The Grb2-mSos1 complex binds phosphopeptides with higher affinity than Grb2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62245)
12. [Interaction domains of Sos1/Grb2 are finely tuned for cooperative control of embryonic stem cell fate](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62245)
13. [The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62245)
14. [Directed discovery of bivalent peptide ligands to an SH3 domain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62245)
15. [Molecular determinants of TRIF proteolysis mediated by the hepatitis C virus NS3/4A protease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62245)
16. [Functional redundancy of Sos1 and Sos2 for lymphopoiesis and organismal homeostasis and survival](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62245)
17. [Mutation in Sos1 dominantly enhances a weak allele of the EGFR, demonstrating a requirement for Sos1 in EGFR signaling and development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62245)
18. [Local phosphatidylinositol 3,4,5-trisphosphate accumulation recruits Vav2 and Vav3 to activate Rac1/Cdc42 and initiate neurite outgrowth in nerve growth factor-stimulated PC12 cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62245)
19. [Nerve growth factor-dependent activation of the small GTPase Rin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62245)
20. ensembl Release 106
21. [Identifiers.org](https://registry.identifiers.org/registry/uniprot)