# SOS Ras/Rac guanine nucleotide exchange factor 1

> mammalian protein found in Homo sapiens

**Wikidata**: [Q7392096](https://www.wikidata.org/wiki/Q7392096)  
**Source**: https://4ort.xyz/entity/sos-ras-rac-guanine-nucleotide-exchange-factor-1-q7392096


## References

1. UniProt
2. Q20641742
3. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07889)
4. [Crystal Structure of the Dbl and Pleckstrin Homology Domains from the Human Son of Sevenless Protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07889)
5. [Identification of Grb4/Nckbeta, a src homology 2 and 3 domain-containing adapter protein having similar binding and biological properties to Nck](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07889)
6. [Differential interactions of human Sos1 and Sos2 with Grb2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07889)
7. [A proteomics strategy to elucidate functional protein-protein interactions applied to EGF signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07889)
8. [Selected reaction monitoring mass spectrometry reveals the dynamics of signaling through the GRB2 adaptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07889)
9. [Differences in flexibility underlie functional differences in the Ras activators son of sevenless and Ras guanine nucleotide releasing factor 1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07889)
10. [Membrane-dependent signal integration by the Ras activator Son of sevenless](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07889)
11. [SH3 domains of Grb2 adaptor bind to PXpsiPXR motifs within the Sos1 nucleotide exchange factor in a discriminate manner](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07889)
12. [Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07889)
13. [The structural basis of the activation of Ras by Sos](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07889)
14. [Characterization of interactions of Nck with Sos and dynamin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07889)
15. [A novel proteomic screen for peptide-protein interactions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07889)
16. [Sos-mediated activation of rac1 by p66shc](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07889)
17. [Catalytic competence of the Ras-GEF domain of hSos1 requires intra-REM domain interactions mediated by phenylalanine 577](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07889)
18. [Shc phosphotyrosine-binding domain dominantly interacts with epidermal growth factor receptors and mediates Ras activation in intact cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07889)
19. [Structural evidence for feedback activation by Ras.GTP of the Ras-specific nucleotide exchange factor SOS](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07889)
20. [Regulation of Sos Activity by Intramolecular Interactions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07889)
21. [Identification of novel SH3 domain ligands for the Src family kinase Hck. Wiskott-Aldrich syndrome protein (WASP), WASP-interacting protein (WIP), and ELMO1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07889)
22. [Analysis of protein-protein interactions in cross-talk pathways reveals CRKL protein as a novel prognostic marker in hepatocellular carcinoma](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07889)
23. [Isoform-selective interaction of the adaptor protein Tks5/FISH with Sos1 and dynamins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07889)
24. [Independent binding of peptide ligands to the SH2 and SH3 domains of Grb2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07889)
25. [Subsets of epidermal growth factor receptors during activation and endocytosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07889)
26. [Structural analysis of autoinhibition in the Ras activator Son of sevenless](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07889)
27. [Charting the molecular network of the drug target Bcr-Abl](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07889)
28. [Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein–Protein Interactions in a Pathway Network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07889)
29. [Interaction of nebulin SH3 domain with titin PEVK and myopalladin: implications for the signaling and assembly role of titin and nebulin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07889)
30. [NMR structure of the N-terminal SH3 domain of GRB2 and its complex with a proline-rich peptide from Sos](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07889)
31. [The CSN3 subunit of the COP9 signalosome interacts with the HD region of Sos1 regulating stability of this GEF protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07889)
32. [Toward an understanding of the protein interaction network of the human liver](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07889)
33. [Solution structure of a Hck SH3 domain ligand complex reveals novel interaction modes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07889)
34. [Disabled-2 (Dab2) is an SH3 domain-binding partner of Grb2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07889)
35. [Role of the histone domain in the autoinhibition and activation of the Ras activator Son of Sevenless](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07889)
36. [Structural basis for the transforming activity of human cancer-related signaling adaptor protein CRK](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07889)
37. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07889&geneProductId=UniProtKB:Q07889)
38. [The motogenic and mitogenic responses to HGF are amplified by the Shc adaptor protein](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07889&geneProductId=UniProtKB:Q07889)
39. [The motogenic and mitogenic responses to HGF are amplified by the Shc adaptor protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07889)
40. [Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07889)
41. Ensembl Release 99
42. UMLS 2023