# Sortilin 1

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21172409](https://www.wikidata.org/wiki/Q21172409)  
**Source**: https://4ort.xyz/entity/sortilin-1-q21172409


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q99523)
3. Q20641742
4. [Sortilin is essential for proNGF-induced neuronal cell death](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99523)
5. [The 100-kDa Neurotensin Receptor Is gp95/Sortilin, A Non-G-Protein-coupled Receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99523)
6. [The Role of Ceroid Lipofuscinosis Neuronal Protein 5 (CLN5) in Endosomal Sorting](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99523)
7. [Sortilin-mediated endocytosis determines levels of the frontotemporal dementia protein, progranulin.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99523)
8. [Impaired prosaposin lysosomal trafficking in frontotemporal lobar degeneration due to progranulin mutations](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99523)
9. [Sortilin associates with Trk receptors to enhance anterograde transport and neurotrophin signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99523)
10. [Sortilin/neurotensin receptor-3 binds and mediates degradation of lipoprotein lipase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99523)
11. [Progranulin directly binds to the CRD2 and CRD3 of TNFR extracellular domains](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99523)
12. [Golgi-localizing, gamma-adaptin ear homology domain, ADP-ribosylation factor-binding (GGA) proteins interact with acidic dileucine sequences within the cytoplasmic domains of sorting receptors through their Vps27p/Hrs/STAM (VHS) domains](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99523)
13. [Multiple modification and protein interaction signals drive the Ring finger protein 11 (RNF11) E3 ligase to the endosomal compartment](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99523)
14. [Misregulation of human sortilin splicing leads to the generation of a nonfunctional progranulin receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99523)
15. [Ligands bind to Sortilin in the tunnel of a ten-bladed beta-propeller domain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99523)
16. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99523)
17. [Sortilin is essential and sufficient for the formation of Glut4 storage vesicles in 3T3-L1 adipocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99523)
18. [The sortilin cytoplasmic tail conveys Golgi-endosome transport and binds the VHS domain of the GGA2 sorting protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99523)
19. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99523&geneProductId=UniProtKB:Q99523)
20. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99523)
21. [Functional role of sortilin in myogenesis and development of insulin-responsive glucose transport system in C2C12 myocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99523)
22. Ensembl Release 99
23. Transporter Classification database