Solute carrier family 8 member A1
type: Thing
description: mammalian protein found in Homo sapiens
additional property: PropertyValue
  property ID: P31
  value: protein
additional property: PropertyValue
  property ID: P352
  value: P32418
additional property: PropertyValue
  property ID: P361
  value: Sodium/calcium exchanger, isoform 1
additional property: PropertyValue
  property ID: P361
  value: CalX-like domain superfamily
additional property: PropertyValue
  property ID: P361
  value: sodium/calcium exchanger protein
additional property: PropertyValue
  property ID: P527
  value: Na-Ca exchanger/integrin-beta4
additional property: PropertyValue
  property ID: P527
  value: Sodium/calcium exchanger membrane region
additional property: PropertyValue
  property ID: P527
  value: Sodium/calcium exchanger domain, C-terminal extension
additional property: PropertyValue
  property ID: P637
  value: NP_001106271
additional property: PropertyValue
  property ID: P637
  value: NP_001106272
additional property: PropertyValue
  property ID: P637
  value: NP_001106273
additional property: PropertyValue
  property ID: P680
  value: ankyrin binding
additional property: PropertyValue
  property ID: P680
  value: calcium ion binding
additional property: PropertyValue
  property ID: P680
  value: metal ion binding
additional property: PropertyValue
  property ID: P681
  value: sarcolemma
additional property: PropertyValue
  property ID: P681
  value: integral component of membrane
additional property: PropertyValue
  property ID: P681
  value: mitochondrion
additional property: PropertyValue
  property ID: P682
  value: response to muscle stretch
additional property: PropertyValue
  property ID: P682
  value: muscle contraction
additional property: PropertyValue
  property ID: P682
  value: response to hypoxia
additional property: PropertyValue
  property ID: P702
  value: SLC8A1
additional property: PropertyValue
  property ID: P703
  value: Homo sapiens
additional property: PropertyValue
  property ID: P705
  value: ENSP00000332931
additional property: PropertyValue
  property ID: P705
  value: ENSP00000383886
additional property: PropertyValue
  property ID: P705
  value: ENSP00000384763
additional property: PropertyValue
  property ID: P7260
  value: 2.A.19.3.4
confidence:
  popularity graph score:
    score: 0.003
    score pct: 0
    tier: established
    components:
      sitelinks: 0
      sitelinks norm: 0.0
      unique citations: 20
      unique citations norm: 0.008
      monthly pageviews: 0
      monthly pageviews norm: 0.0
  sitelinks: 0
  unique citations: 20
  monthly pageviews: 0
  yearly pageviews: 0
  tier: established
claims:
  P31:
    value: Q8054
    source count: 1
    confidence: 0.2
    value label: protein
  P352:
    value: P32418
    source count: 1
    confidence: 0.2
  P361:
    value: Q24772633
    source count: 1
    confidence: 0.2
    value label: Sodium/calcium exchanger, isoform 1
  P361:
    value: Q54460715
    source count: 1
    confidence: 0.2
    value label: CalX-like domain superfamily
  P361:
    value: Q24724654
    source count: 1
    confidence: 0.2
    value label: sodium/calcium exchanger protein
  P361:
    value: Q83145634
    source count: 1
    confidence: 0.2
    value label: Sodium/calcium exchanger domain, C-terminal extension, protein family
  P361:
    value: Q83134929
    source count: 1
    confidence: 0.2
    value label: DnaJ domain, protein family
  P527:
    value: Q24778116
    source count: 1
    confidence: 0.2
    value label: Na-Ca exchanger/integrin-beta4
  P527:
    value: Q24768320
    source count: 1
    confidence: 0.2
    value label: Sodium/calcium exchanger membrane region
  P527:
    value: Q24775654
    source count: 1
    confidence: 0.2
    value label: Sodium/calcium exchanger domain, C-terminal extension
  P527:
    value: Q24724559
    source count: 1
    confidence: 0.2
    value label: DnaJ domain
  P637:
    value: NP_001106271
    source count: 1
    confidence: 0.2
  P637:
    value: NP_001106272
    source count: 1
    confidence: 0.2
  P637:
    value: NP_001106273
    source count: 1
    confidence: 0.2
  P637:
    value: NP_001239553
    source count: 1
    confidence: 0.2
  P637:
    value: NP_066920
    source count: 1
    confidence: 0.2
  P680:
    value: Q14877657
    source count: 2
    confidence: 0.4
    value label: ankyrin binding
  P680:
    value: Q14633862
    source count: 1
    confidence: 0.2
    value label: calcium ion binding
  P680:
    value: Q13667380
    source count: 1
    confidence: 0.2
    value label: metal ion binding
  P680:
    value: Q14881097
    source count: 1
    confidence: 0.2
    value label: antiporter activity
  P680:
    value: Q14819275
    source count: 1
    confidence: 0.2
    value label: calmodulin binding
  P681:
    value: Q1545001
    source count: 2
    confidence: 0.4
    value label: sarcolemma

value: Q14327652
source count: 2
confidence: 0.4
value label: integral component of membrane

value: Q39572
source count: 1
confidence: 0.2
value label: mitochondrion

value: Q14353100
source count: 1
confidence: 0.2
value label: cell projection

value: Q14860360
source count: 1
confidence: 0.2
value label: dendritic shaft

value: Q21095369
source count: 1
confidence: 0.2
value label: response to muscle stretch

value: Q127006
source count: 1
confidence: 0.2
value label: muscle contraction

value: Q14819239
source count: 1
confidence: 0.2
value label: response to hypoxia

value: Q21100531
source count: 1
confidence: 0.2
value label: cellular response to caffeine

value: Q14886906
source count: 1
confidence: 0.2
value label: telencephalon development

value: Q18031549
source count: 1
confidence: 0.2
value label: SLC8A1

value: Q15978631
source count: 1
confidence: 0.2
value label: Homo sapiens

value: ENSP00000332931
source count: 1
confidence: 0.2

value: ENSP00000383886
source count: 1
confidence: 0.2

value: ENSP00000384763
source count: 1
confidence: 0.2

value: ENSP00000384908
source count: 1
confidence: 0.2

value: ENSP00000385188
source count: 1
confidence: 0.2

value: 2.A.19.3.4
source count: 2
confidence: 0.4

source: GOA
stated in qid: Q28018111
retrieved: 2019-04-08

source: Targeting and stability of Na/Ca exchanger 1 in cardiomyocytes requires direct interaction with the membrane adaptor ankyrin-B
stated in qid: Q24337311
retrieved: 2019-04-08

source: Ankyrin-B coordinates the Na/K ATPase, Na/Ca exchanger, and InsP3 receptor in a cardiac T-tubule/SR microdomain
stated in qid: Q24295272
retrieved: 2019-04-08

source: Anoctamin-6 Controls Bone Mineralization by Activating the Calcium Transporter NCX1
stated in qid: Q24314842
retrieved: 2019-04-08

source: GOA
stated in qid: Q28018111
retrieved: 2018-01-01

source: Anoctamin-6 Controls Bone Mineralization by Activating the Calcium Transporter NCX1
stated in qid: Q24314842
retrieved: 2018-01-01

source: Molecular cloning and characterization of the human cardiac Na+/Ca2+ exchanger cDNA
stated in qid: Q24292754
retrieved: 2018-01-01

source: Molecular cloning and characterization of the human cardiac Na+/Ca2+ exchanger cDNA
stated in qid: Q24292754
retrieved: 2019-04-08

source: Regulation and role of the presynaptic and myocardial Na+/H+ exchanger NHE1: effects on the sympathetic nervous system in heart failure
stated in qid: Q24317445
retrieved: 2019-04-08

source: New molecular components supporting ryanodine receptor-mediated Ca(2+) release: roles of junctophilin and TRIC channel in embryonic cardiomyocytes
stated in qid: Q24309139
retrieved: 2019-04-08

source: Functional relevance of the stretch-dependent slow force response in failing human myocardium
stated in qid: Q24337669
retrieved: 2019-04-08

source: Coordinated Regulation of Cardiac Na+/Ca2+ Exchanger and Na+-K+-ATPase by Phospholemman (FXYD1)
stated in qid: Q24305469
retrieved: 2019-04-08

source: Na+ transport in the normal and failing heart — Remember the balance
stated in qid: Q24338863
retrieved: 2019-04-08

source: Reactive oxygen species directly modify sodium-calcium exchanger activity in a splice variant-dependent manner
stated in qid: Q24315347
retrieved: 2019-04-08

source: Reactive oxygen species directly modify sodium-calcium exchanger activity in a splice variant-dependent manner
stated in qid: Q24315347
retrieved: 2018-02-27

source: InterPro Release 71.0
stated in qid: Q58943792

source: UniProt
stated in qid: Q905695
retrieved: 2019-11-13

source: Q20641742
stated in qid: Q20641742
retrieved: 2020-05-30

source: Transporter Classification database
stated in qid: Q142667
retrieved: 2020-03-13

source: Ensembl Release 99
stated in qid: Q83867711

wikidata id: Q21119536
domain: protein
level: standard
html url: https://4ort.xyz/entity/solute-carrier-family-8-member-a1-q21119536
markdown url: https://4ort.xyz/entity/solute-carrier-family-8-member-a1-q21119536.md
facts url summary: https://4ort.xyz/entity/solute-carrier-family-8-member-a1-q21119536/facts.json
facts url standard: https://4ort.xyz/entity/solute-carrier-family-8-member-a1-q21119536/facts.json
facts url full: https://4ort.xyz/entity/solute-carrier-family-8-member-a1-q21119536/facts.json
data source: Wikidata (CC0 / public domain)
license: https://creativecommons.org/publicdomain/zero/1.0/
api version: v1
served at: 2026-08-06T17:13:56.810556Z
entity updated at: 2026-05-03T18:28:36.114423+00:00Z
entity created at: 2026-05-03T15:12:06.018882+00:00Z