Solute carrier family 40 (iron-regulated transporter), member 1
type: Thing
description: mammalian protein found in Mus musculus
additional property: PropertyValue
  property ID: P31
  value: protein
additional property: PropertyValue
  property ID: P361
  value: ferroportin
additional property: PropertyValue
  property ID: P361
  value: MFS transporter superfamily
additional property: PropertyValue
  property ID: P637
  value: NP_058613
additional property: PropertyValue
  property ID: P637
  value: XP_006496200
additional property: PropertyValue
  property ID: P637
  value: XP_017177198
additional property: PropertyValue
  property ID: P680
  value: ferrous iron transmembrane transporter activity
additional property: PropertyValue
  property ID: P680
  value: iron ion transmembrane transporter activity
additional property: PropertyValue
  property ID: P680
  value: iron ion transmembrane transporter activity
additional property: PropertyValue
  property ID: P681
  value: integral component of membrane
additional property: PropertyValue
  property ID: P681
  value: membrane
additional property: PropertyValue
  property ID: P681
  value: synaptic vesicle
additional property: PropertyValue
  property ID: P682
  value: iron ion transmembrane transport
additional property: PropertyValue
  property ID: P682
  value: lymphocyte homeostasis
additional property: PropertyValue
  property ID: P682
  value: spleen trabecula formation
additional property: PropertyValue
  property ID: P702
  value: Slc40a1
additional property: PropertyValue
  property ID: P703
  value: house mouse
additional property: PropertyValue
  property ID: P705
  value: ENSMUSP00000027137
additional property: PropertyValue
  property ID: P705
  value: ENSMUSP00000140549
additional property: PropertyValue
  property ID: P705
  value: ENSMUSP00000140734
additional property: PropertyValue
  property ID: P2888
  value: https://identifiers.org/uniprot:Q9JHI9
additional property: PropertyValue
  property ID: P2888
  value: http://purl.uniprot.org/uniprot/Q9JHI9
additional property: PropertyValue
  property ID: P2888
  value: https://www.ncbi.nlm.nih.gov/protein/Q9JHI9
additional property: PropertyValue
  property ID: P7260
  value: 2.A.100.1.1
confidence:
  popularity graph score:
    score: 0.003
    score pct: 0
    tier: established
    components:
      sitelinks: 0
      sitelinks norm: 0.0
      unique citations: 23
      unique citations norm: 0.009
      monthly pageviews: 0
      monthly pageviews norm: 0.0
  sitelinks: 0
  unique citations: 23
  monthly pageviews: 0
  yearly pageviews: 0
  tier: established
claims:
  P31:
    value: Q8054
    source count: 1
    confidence: 0.2
    value label: protein
  P352:
    value: Q9JHI9
    source count: 1
    confidence: 0.2
  P361:
    value: Q24777245
    source count: 2
    confidence: 0.4
    value label: ferroportin
  P361:
    value: Q41797380
    source count: 1
    confidence: 0.2
    value label: MFS transporter superfamily
  P637:
    value: NP_058613
    source count: 1
    confidence: 0.2
  P637:
    value: XP_006496200
    source count: 1
    confidence: 0.2
  P637:
    value: XP_017177198
    source count: 1
    confidence: 0.2
  P680:
    value: Q14914117
    source count: 1
    confidence: 0.2
    value label: ferrous iron transmembrane transporter activity
  P680:
    value: Q14878802
    source count: 4
    confidence: 0.8
    value label: iron ion transmembrane transporter activity
  P680:
    value: Q14878802
    source count: 1
    confidence: 0.2
    value label: iron ion transmembrane transporter activity
  P680:
    value: Q14875276
    source count: 3
    confidence: 0.6
    value label: peptide hormone binding
  P680:
    value: Q167149
    source count: 3
    confidence: 0.6
    value label: protein binding
  P681:
    value: Q14327652
    source count: 2
    confidence: 0.4
    value label: integral component of membrane
  P681:
    value: Q14349455
    source count: 1
    confidence: 0.2
    value label: membrane
  P681:
    value: Q671136
    source count: 1
    confidence: 0.2
    value label: synaptic vesicle
  P681:
    value: Q29548
    source count: 5
    confidence: 1.0
    value label: plasma membrane
  P681:
    value: Q3824358
    source count: 2
    confidence: 0.4
    value label: intracellular anatomical structure
  P682:
    value: Q14878803
    source count: 4
    confidence: 0.8
    value label: iron ion transmembrane transport
  P682:
    value: Q14863460
    source count: 1
    confidence: 0.2
    value label: lymphocyte homeostasis
  P682:
    value: Q14878804
    source count: 1
    confidence: 0.2
    value label: spleen trabecula formation
  P682:
    value: Q14860561
    source count: 2
    confidence: 0.4
    value label: iron ion homeostasis
  P682:
    value: Q14599533
    source count: 1
    confidence: 0.2
    value label: negative regulation of apoptotic process
  P702:
    value: Q14878807
    source count: 1
    confidence: 0.2
    value label: Slc40a1

value: Q83310
source count: 1
confidence: 0.2
value label: house mouse

value: ENSMUSP00000027137
source count: 1
confidence: 0.2

value: ENSMUSP00000140549
source count: 1
confidence: 0.2

value: ENSMUSP00000140734
source count: 1
confidence: 0.2

value: ENSMUSP00000140969
source count: 1
confidence: 0.2

value: https://identifiers.org/uniprot:Q9JHI9
source count: 1
confidence: 0.2

value: http://purl.uniprot.org/uniprot/Q9JHI9
source count: 1
confidence: 0.2

value: https://www.ncbi.nlm.nih.gov/protein/Q9JHI9
source count: 1
confidence: 0.2

value: 2.A.100.1.1
source count: 2
confidence: 0.4

source: Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization
stated in qid: Q24310115
retrieved: 2019-05-09

source: GOA
stated in qid: Q28018111
retrieved: 2019-02-14

source: Assignment of Slc11a3 to mouse chromosome 1 band 1B and SLC11A3 to human chromosome 2q32 by in situ hybridization
stated in qid: Q28145294
retrieved: 2019-02-14

source: Hepcidin mediates transcriptional changes that modulate acute cytokine-induced inflammatory responses in mice
stated in qid: Q24617847
retrieved: 2019-05-09

source: Iron-export ferroxidase activity of β-amyloid precursor protein is inhibited by zinc in Alzheimer's disease
stated in qid: Q24298553
retrieved: 2019-05-09

source: Hepcidin-induced internalization of ferroportin requires binding and cooperative interaction with Jak2.
stated in qid: Q37129387
retrieved: 2019-05-09

source: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
stated in qid: Q34211397
retrieved: 2019-05-09

source: Expression of the iron transporter ferroportin in synaptic vesicles and the blood-brain barrier
stated in qid: Q28507937
retrieved: 2019-05-09

source: Presence of the iron exporter ferroportin at the plasma membrane of macrophages is enhanced by iron loading and down-regulated by hepcidin
stated in qid: Q28513640
retrieved: 2019-05-09

source: Hepcidin regulates ferroportin expression and intracellular iron homeostasis of erythroblasts
stated in qid: Q28585215
retrieved: 2019-05-09

source: GOA
stated in qid: Q28018111
retrieved: 2018-09-10

source: Lack of the bone morphogenetic protein BMP6 induces massive iron overload
stated in qid: Q28510138
retrieved: 2019-02-14

source: Otx2 regulates subtype specification and neurogenesis in the midbrain
stated in qid: Q28505456
retrieved: 2019-05-09

source: Dysregulation of ferroportin 1 interferes with spleen organogenesis in polycythaemia mice
stated in qid: Q28509304
retrieved: 2019-05-09

source: Brain and retinal ferroportin 1 dysregulation in polycythaemia mice
stated in qid: Q28591218
retrieved: 2019-02-14

source: Disruption of ferroportin 1 regulation causes dynamic alterations in iron homeostasis and erythropoiesis in polycythaemia mice
stated in qid: Q24336909
retrieved: 2019-05-09

source: HRG1 Is Essential for Heme Transport from the Phagolysosome of Macrophages during Erythrophagocytosis
stated in qid: Q24315610
retrieved: 2019-05-09

source: InterPro Release 71.0
stated in qid: Q58943792

source: Identifiers.org
stated in qid: Q16335163

source: UniProt
stated in qid: Q905695
retrieved: 2022-05-25

source: Q20641742
stated in qid: Q20641742
retrieved: 2022-03-20

source: Transporter Classification database
stated in qid: Q142667
retrieved: 2020-03-13

source: ensembl Release 106
stated in qid: Q111699881

wikidata id: Q14878808
domain: protein
level: standard
html url: https://4ort.xyz/entity/solute-carrier-family-40-iron-regulated-transporter-member-1
markdown url: https://4ort.xyz/entity/solute-carrier-family-40-iron-regulated-transporter-member-1.md
facts url summary: https://4ort.xyz/entity/solute-carrier-family-40-iron-regulated-transporter-member-1/facts.json
facts url standard: https://4ort.xyz/entity/solute-carrier-family-40-iron-regulated-transporter-member-1/facts.json
facts url full: https://4ort.xyz/entity/solute-carrier-family-40-iron-regulated-transporter-member-1/facts.json
data source: Wikidata (CC0 / public domain)
license: https://creativecommons.org/publicdomain/zero/1.0/
api version: v1
served at: 2026-08-03T21:25:19.924918Z
entity updated at: 2026-05-03T18:28:36.114423+00:00Z
entity created at: 2026-05-03T13:46:20.697850+00:00Z