Solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
type: Thing
description: mammalian protein found in Mus musculus
additional property: PropertyValue
  property ID: P31
  value: protein
additional property: PropertyValue
  property ID: P352
  value: P51906
additional property: PropertyValue
  property ID: P361
  value: Sodium:dicarboxylate symporter superfamily
additional property: PropertyValue
  property ID: P361
  value: Sodium:dicarboxylate symporter
additional property: PropertyValue
  property ID: P361
  value: Sodium:dicarboxylate symporter, conserved site, protein family
additional property: PropertyValue
  property ID: P527
  value: Sodium:dicarboxylate symporter, conserved site
additional property: PropertyValue
  property ID: P637
  value: NP_033225
additional property: PropertyValue
  property ID: P680
  value: cysteine transmembrane transporter activity
additional property: PropertyValue
  property ID: P680
  value: protein binding
additional property: PropertyValue
  property ID: P680
  value: symporter activity
additional property: PropertyValue
  property ID: P681
  value: integral component of membrane
additional property: PropertyValue
  property ID: P681
  value: membrane
additional property: PropertyValue
  property ID: P681
  value: plasma membrane
additional property: PropertyValue
  property ID: P682
  value: D-aspartate import across plasma membrane
additional property: PropertyValue
  property ID: P682
  value: positive regulation of heart rate
additional property: PropertyValue
  property ID: P682
  value: cysteine transport
additional property: PropertyValue
  property ID: P702
  value: Slc1a1
additional property: PropertyValue
  property ID: P703
  value: house mouse
additional property: PropertyValue
  property ID: P705
  value: ENSMUSP00000025875
confidence:
  popularity graph score:
    score: 0.002
    score pct: 0
    tier: established
    components:
      sitelinks: 0
      sitelinks norm: 0.0
      unique citations: 13
      unique citations norm: 0.005
      monthly pageviews: 0
      monthly pageviews norm: 0.0
  sitelinks: 0
  unique citations: 13
  monthly pageviews: 0
  yearly pageviews: 0
  tier: established
claims:
  P31:
    value: Q8054
    source count: 1
    confidence: 0.2
    value label: protein
  P352:
    value: P51906
    source count: 1
    confidence: 0.2
  P361:
    value: Q41797564
    source count: 1
    confidence: 0.2
    value label: Sodium:dicarboxylate symporter superfamily
  P361:
    value: Q24772475
    source count: 1
    confidence: 0.2
    value label: Sodium:dicarboxylate symporter
  P361:
    value: Q95351263
    source count: 1
    confidence: 0.2
    value label: Sodium:dicarboxylate symporter, conserved site, protein family
  P527:
    value: Q24773222
    source count: 1
    confidence: 0.2
    value label: Sodium:dicarboxylate symporter, conserved site
  P637:
    value: NP_033225
    source count: 1
    confidence: 0.2
  P680:
    value: Q21114339
    source count: 3
    confidence: 0.6
    value label: cysteine transmembrane transporter activity
  P680:
    value: Q167149
    source count: 3
    confidence: 0.6
    value label: protein binding
  P680:
    value: Q14860823
    source count: 2
    confidence: 0.4
    value label: symporter activity
  P680:
    value: Q14905282
    source count: 3
    confidence: 0.6
    value label: L-glutamate transmembrane transporter activity
  P680:
    value: Q13667380
    source count: 1
    confidence: 0.2
    value label: metal ion binding
  P681:
    value: Q14327652
    source count: 2
    confidence: 0.4
    value label: integral component of membrane
  P681:
    value: Q14349455
    source count: 1
    confidence: 0.2
    value label: membrane
  P681:
    value: Q29548
    source count: 4
    confidence: 0.8
    value label: plasma membrane
  P681:
    value: Q14819446
    source count: 4
    confidence: 0.8
    value label: apical plasma membrane
  P681:
    value: Q14859540
    source count: 3
    confidence: 0.6
    value label: integral component of plasma membrane
  P682:
    value: Q14913169
    source count: 2
    confidence: 0.4
    value label: D-aspartate import across plasma membrane
  P682:
    value: Q14864771
    source count: 1
    confidence: 0.2
    value label: positive regulation of heart rate
  P682:
    value: Q21114340
    source count: 3
    confidence: 0.6
    value label: cysteine transport
  P682:
    value: Q14882516
    source count: 2
    confidence: 0.4
    value label: L-glutamate import
  P682:
    value: Q22290575
    source count: 1
    confidence: 0.2
    value label: cysteine transmembrane transport
  P702:
    value: Q18254133
    source count: 1
    confidence: 0.2
    value label: Slc1a1
  P703:
    value: Q83310
    source count: 1
    confidence: 0.2
    value label: house mouse
  P705:
    value: ENSMUSP00000025875
    source count: 1
    confidence: 0.2
citations:
  source: GOA
  stated in qid: Q28018111
  retrieved: 2019-02-14

source: SorCS2 Controls Functional Expression of Amino Acid Transporter EAAT3 and Protects Neurons from Oxidative Stress and Epilepsy-Induced Pathology
stated in qid: Q64025565
retrieved: 2019-05-09

source: Modulation of the neural glutamate transporter EAAC1 by the addicsin-interacting protein ARL6IP1
stated in qid: Q28589307
retrieved: 2019-05-09

source: Unique anti-apoptotic activity of EAAC1 in injured motor neurons
stated in qid: Q28506214
retrieved: 2019-05-09

source: Presenilin-1 and intracellular calcium stores regulate neuronal glutamate uptake
stated in qid: Q28511563
retrieved: 2019-05-09

source: Molecular cloning, gene structure, expression profile and functional characterization of the mouse glutamate transporter (EAAT3) interacting protein GTRAP3-18
stated in qid: Q28214734
retrieved: 2019-05-09

source: GOA
stated in qid: Q28018111
retrieved: 2018-04-24

source: The cystine-glutamate exchanger (xCT, Slc7a11) is expressed in significant concentrations in a subpopulation of astrocytes in the mouse brain
stated in qid: Q47852091
retrieved: 2019-05-09

source: Glutamate transporter type 3 knockout leads to decreased heart rate possibly via parasympathetic mechanism
stated in qid: Q28511942
retrieved: 2019-05-09

source: InterPro Release 71.0
stated in qid: Q58943792

source: UniProt
stated in qid: Q905695
retrieved: 2022-05-25

source: Q20641742
stated in qid: Q20641742
retrieved: 2022-03-20

source: ensembl Release 106
stated in qid: Q111699881

wikidata id: Q21497239
domain: protein
level: standard
html url: https://4ort.xyz/entity/solute-carrier-family-1-neuronal-epithelial-high-affinity-glutamate-transporter-system-xag-member-1
markdown url: https://4ort.xyz/entity/solute-carrier-family-1-neuronal-epithelial-high-affinity-glutamate-transporter-system-xag-member-1.md
facts url summary: https://4ort.xyz/entity/solute-carrier-family-1-neuronal-epithelial-high-affinity-glutamate-transporter-system-xag-member-1/facts.json
facts url standard: https://4ort.xyz/entity/solute-carrier-family-1-neuronal-epithelial-high-affinity-glutamate-transporter-system-xag-member-1/facts.json
facts url full: https://4ort.xyz/entity/solute-carrier-family-1-neuronal-epithelial-high-affinity-glutamate-transporter-system-xag-member-1/facts.json
data source: Wikidata (CC0 / public domain)
license: https://creativecommons.org/publicdomain/zero/1.0/
api version: v1
served at: 2026-08-12T05:35:17.165030Z
entity updated at: 2026-05-03T18:28:36.114423+00:00Z
entity created at: 2026-05-03T15:12:15.838670+00:00Z