# Sodium voltage-gated channel alpha subunit 5

> mammalian protein found in Homo sapiens

**Wikidata**: [Q3459294](https://www.wikidata.org/wiki/Q3459294)  
**Source**: https://4ort.xyz/entity/sodium-voltage-gated-channel-alpha-subunit-5-q3459294


## References

1. UniProt
2. IUPHAR/BPS Guide to PHARMACOLOGY
3. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL861)
4. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL1200612)
5. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL1201242)
6. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL1200)
7. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL1068)
8. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL29741)
9. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL3184437)
10. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL2107771)
11. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL3678076)
12. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL79)
13. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL750)
14. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL220492)
15. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL944)
16. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL315985)
17. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL1200822)
18. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL1200437)
19. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL1201020)
20. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL1200478)
21. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL1200440)
22. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL1200606)
23. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL1200395)
24. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL605)
25. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL1201063)
26. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL1200654)
27. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL1200586)
28. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q14524)
29. Q20641742
30. [Syntrophin mutation associated with long QT syndrome through activation of the nNOS-SCN5A macromolecular complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14524)
31. [Mutations in SCN10A are responsible for a large fraction of cases of Brugada syndrome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14524)
32. [SCN4B-encoded sodium channel beta4 subunit in congenital long-QT syndrome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14524)
33. [Loss-of-function mutation of the SCN3B-encoded sodium channel {beta}3 subunit associated with a case of idiopathic ventricular fibrillation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14524)
34. [Cell membrane expression of cardiac sodium channel Na(v)1.5 is modulated by alpha-actinin-2 interaction](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14524)
35. [Correlations between clinical and physiological consequences of the novel mutation R878C in a highly conserved pore residue in the cardiac Na+ channel](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14524)
36. [Combination of cardiac conduction disease and long QT syndrome caused by mutation T1620K in the cardiac sodium channel](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14524)
37. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14524)
38. [Multifocal ectopic Purkinje-related premature contractions: a new SCN5A-related cardiac channelopathy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14524)
39. [SCN5A variant that blocks fibroblast growth factor homologous factor regulation causes human arrhythmia](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14524)
40. [Cardiac sodium channel Na(v)1.5 interacts with and is regulated by the protein tyrosine phosphatase PTPH1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14524)
41. [Ca2+/calmodulin-dependent protein kinase II (CaMKII) regulates cardiac sodium channel NaV1.5 gating by multiple phosphorylation sites](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14524)
42. [Protein arginine methyl transferases-3 and -5 increase cell surface expression of cardiac sodium channel](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14524)
43. [Crystal Structure of the Ternary Complex of a NaV C-Terminal Domain, a Fibroblast Growth Factor Homologous Factor, and Calmodulin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14524)
44. [14-3-3 is a regulator of the cardiac voltage-gated sodium channel Nav1.5](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14524)
45. [Identification of a new co-factor, MOG1, required for the full function of cardiac sodium channel Nav 1.5](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14524)
46. [Nav1.5 E1053K mutation causing Brugada syndrome blocks binding to ankyrin-G and expression of Nav1.5 on the surface of cardiomyocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14524)
47. [GPD1L links redox state to cardiac excitability by PKC-dependent phosphorylation of the sodium channel SCN5A](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14524)
48. [Modulation of the cardiac sodium channel Nav1.5 by fibroblast growth factor homologous factor 1B](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14524)
49. [Mexiletine differentially restores the trafficking defects caused by two brugada syndrome mutations](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14524)
50. [Multiple arrhythmic syndromes in a newborn, owing to a novel mutation in SCN5A](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14524)