# smoothened, frizzled class receptor

> mammalian protein found in Homo sapiens

**Wikidata**: [Q3271551](https://www.wikidata.org/wiki/Q3271551)  
**Source**: https://4ort.xyz/entity/smoothened-frizzled-class-receptor-q3271551


## References

1. UniProt
2. IUPHAR/BPS Guide to PHARMACOLOGY
3. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL538867)
4. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL473417)
5. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL2105737)
6. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL3545403)
7. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL2043437)
8. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL2205230)
9. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q99835)
10. Q20641742
11. Freebase Data Dumps. 2013
12. [Characterization of two patched receptors for the vertebrate hedgehog protein family](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99835&geneProductId=UniProtKB:Q99835)
13. [The mammalian Cos2 homolog Kif7 plays an essential role in modulating Hh signal transduction during development](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99835&geneProductId=UniProtKB:Q99835)
14. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99835&geneProductId=UniProtKB:Q99835)
15. [The sonic hedgehog receptor patched associates with caveolin-1 in cholesterol-rich microdomains of the plasma membrane](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99835&geneProductId=UniProtKB:Q99835)
16. [Large-scale proteomics and phosphoproteomics of urinary exosomes](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99835&geneProductId=UniProtKB:Q99835)
17. [In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99835&geneProductId=UniProtKB:Q99835)
18. [Evidence for allosteric interactions of antagonist binding to the smoothened receptor](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99835&geneProductId=UniProtKB:Q99835)
19. [The hedgehog receptor patched is involved in cholesterol transport](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99835&geneProductId=UniProtKB:Q99835)
20. [Immunohistochemical analysis of Sonic hedgehog signalling in normal human urinary tract development](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99835&geneProductId=UniProtKB:Q99835)
21. [Identification and Mechanism of Action of the Acylguanidine MRT-83, a Novel Potent Smoothened Antagonist](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99835&geneProductId=UniProtKB:Q99835)
22. [Activating Smoothened mutations in sporadic basal-cell carcinoma](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99835&geneProductId=UniProtKB:Q99835)
23. Ensembl Release 99
24. UMLS 2023
25. Transporter Classification database