# Smoothened, frizzled class receptor

> mammalian protein found in Mus musculus

**Wikidata**: [Q21986823](https://www.wikidata.org/wiki/Q21986823)  
**Source**: https://4ort.xyz/entity/smoothened-frizzled-class-receptor-q21986823


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P56726)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P56726&geneProductId=UniProtKB:P56726)
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726)
6. [Growth Arrest Specific 8 (Gas8) and G protein-coupled receptor kinase 2 (GRK2) cooperate in the control of Smoothened signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726)
7. [Bifurcating action of Smoothened in Hedgehog signaling is mediated by Dlg5.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726)
8. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726)
9. [Bifurcating action of Smoothened in Hedgehog signaling is mediated by Dlg5.](http://www.ebi.ac.uk/QuickGO/annotations?protein=P56726&geneProductId=UniProtKB:P56726)
10. [Growth Arrest Specific 8 (Gas8) and G protein-coupled receptor kinase 2 (GRK2) cooperate in the control of Smoothened signaling](http://www.ebi.ac.uk/QuickGO/annotations?protein=P56726&geneProductId=UniProtKB:P56726)
11. [The primary cilium coordinates early cardiogenesis and hedgehog signaling in cardiomyocyte differentiation](http://www.ebi.ac.uk/QuickGO/annotations?protein=P56726&geneProductId=UniProtKB:P56726)
12. [Loss of the retrograde motor for IFT disrupts localization of Smo to cilia and prevents the expression of both activator and repressor functions of Gli](http://www.ebi.ac.uk/QuickGO/annotations?protein=P56726&geneProductId=UniProtKB:P56726)
13. [The IFT-A complex regulates Shh signaling through cilia structure and membrane protein trafficking](http://www.ebi.ac.uk/QuickGO/annotations?protein=P56726&geneProductId=UniProtKB:P56726)
14. [Intraflagellar transport, cilia, and mammalian Hedgehog signaling: analysis in mouse embryonic fibroblasts](http://www.ebi.ac.uk/QuickGO/annotations?protein=P56726&geneProductId=UniProtKB:P56726)
15. [Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved](http://www.ebi.ac.uk/QuickGO/annotations?protein=P56726&geneProductId=UniProtKB:P56726)
16. [Vertebrate Smoothened functions at the primary cilium](http://www.ebi.ac.uk/QuickGO/annotations?protein=P56726&geneProductId=UniProtKB:P56726)
17. [Intraflagellar transport protein 122 antagonizes Sonic Hedgehog signaling and controls ciliary localization of pathway components](http://www.ebi.ac.uk/QuickGO/annotations?protein=P56726&geneProductId=UniProtKB:P56726)
18. [The hedgehog receptor patched is involved in cholesterol transport](http://www.ebi.ac.uk/QuickGO/annotations?protein=P56726&geneProductId=UniProtKB:P56726)
19. [A ciliopathy complex at the transition zone protects the cilia as a privileged membrane domain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726)
20. [Intraflagellar transport, cilia, and mammalian Hedgehog signaling: analysis in mouse embryonic fibroblasts](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726)
21. [The hedgehog receptor patched is involved in cholesterol transport](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726)
22. [Vertebrate Smoothened functions at the primary cilium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726)
23. [Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726)
24. [The IFT-A complex regulates Shh signaling through cilia structure and membrane protein trafficking](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726)
25. [Tubby family proteins are adapters for ciliary trafficking of integral membrane proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726)
26. [Loss of the retrograde motor for IFT disrupts localization of Smo to cilia and prevents the expression of both activator and repressor functions of Gli](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726)
27. [The primary cilium coordinates early cardiogenesis and hedgehog signaling in cardiomyocyte differentiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726)
28. [Intraflagellar transport protein 122 antagonizes Sonic Hedgehog signaling and controls ciliary localization of pathway components](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726)
29. [Autonomous and nonautonomous roles of Hedgehog signaling in regulating limb muscle formation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726)
30. [alphaE-catenin controls cerebral cortical size by regulating the hedgehog signaling pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726)
31. [Sonic hedgehog signaling regulates reciprocal epithelial-mesenchymal interactions controlling palatal outgrowth](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726)
32. [Hedgehog induction of murine vasculogenesis is mediated by Foxf1 and Bmp4](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726)
33. [Hedgehog signaling is essential for endothelial tube formation during vasculogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726)
34. [A phenotype-based screen for embryonic lethal mutations in the mouse](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726)
35. [Smoothened mutants reveal redundant roles for Shh and Ihh signaling including regulation of L/R symmetry by the mouse node](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726)
36. [GLI3-dependent transcriptional repression of Gli1, Gli2 and kidney patterning genes disrupts renal morphogenesis](http://www.ebi.ac.uk/QuickGO/annotations?protein=P56726&geneProductId=UniProtKB:P56726)
37. [Smoothened controls cyclin D2 expression and regulates the generation of intermediate progenitors in the developing cortex](http://www.ebi.ac.uk/QuickGO/annotations?protein=P56726&geneProductId=UniProtKB:P56726)
38. [Sox17 regulates organ lineage segregation of ventral foregut progenitor cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726)
39. [Abnormal hair development and apparent follicular transformation to mammary gland in the absence of hedgehog signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726)
40. [Shh signaling within the dental epithelium is necessary for cell proliferation, growth and polarization](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726)
41. [Progenitor cell proliferation in the retina is dependent on Notch-independent Sonic hedgehog/Hes1 activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726)
42. [Hepatic Hedgehog signaling contributes to the regulation of IGF1 and IGFBP1 serum levels](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726)
43. [Divergence of hedgehog signal transduction mechanism between Drosophila and mammals](http://www.ebi.ac.uk/QuickGO/annotations?protein=P56726&geneProductId=UniProtKB:P56726)
44. [Sonic hedgehog signaling regulates the expression of insulin-like growth factor binding protein-6 during fetal prostate development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726)
45. [Hedgehog Signaling in Pancreas Epithelium Regulates Embryonic Organ Formation and Adult β-Cell Function](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726)
46. [GLI3-dependent transcriptional repression of Gli1, Gli2 and kidney patterning genes disrupts renal morphogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726)
47. [Wdpcp, a PCP protein required for ciliogenesis, regulates directional cell migration and cell polarity by direct modulation of the actin cytoskeleton](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726)
48. [Smoothened controls cyclin D2 expression and regulates the generation of intermediate progenitors in the developing cortex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726)
49. [Sonic hedgehog regulates Gli activator and repressor functions with spatial and temporal precision in the mid/hindbrain region](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726)
50. [Hedgehog signaling and primary cilia are required for the formation of adult neural stem cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56726)