# Smoothened Dmel_CG11561

> protein found in Drosophila melanogaster

**Wikidata**: [Q29814209](https://www.wikidata.org/wiki/Q29814209)  
**Source**: https://4ort.xyz/entity/smoothened-dmel-cg11561


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P91682)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P91682&geneProductId=UniProtKB:P91682)
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P91682)
6. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P91682)
7. [Hedgehog-regulated Costal2-kinase complexes control phosphorylation and proteolytic processing of Cubitus interruptus.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P91682)
8. [USP8 promotes smoothened signaling by preventing its ubiquitination and changing its subcellular localization](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P91682)
9. [Hedgehog-Regulated Ubiquitination Controls Smoothened Trafficking and Cell Surface Expression in Drosophila](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P91682)
10. [Smoothened transduces Hedgehog signal by physically interacting with Costal2/Fused complex through its C-terminal tail](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P91682)
11. [PI(4)P Promotes Phosphorylation and Conformational Change of Smoothened through Interaction with Its C-terminal Tail](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P91682)
12. [A large complex containing Patched and Smoothened initiates Hedgehog signaling in Drosophila](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P91682)
13. [Identification of a Functional Interaction between the Transmembrane Protein Smoothened and the Kinesin-Related Protein Costal2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P91682)
14. [Hedgehog regulates smoothened activity by inducing a conformational switch](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P91682)
15. [The Hedgehog-induced Smoothened conformational switch assembles a signaling complex that activates Fused by promoting its dimerization and phosphorylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P91682)
16. [Regulation of Hedgehog signaling: a complex story](http://www.ebi.ac.uk/QuickGO/annotations?protein=P91682&geneProductId=UniProtKB:P91682)
17. [Hedgehog induces opposite changes in turnover and subcellular localization of patched and smoothened](http://www.ebi.ac.uk/QuickGO/annotations?protein=P91682&geneProductId=UniProtKB:P91682)
18. [Cilia-mediated hedgehog signaling in Drosophila](http://www.ebi.ac.uk/QuickGO/annotations?protein=P91682&geneProductId=UniProtKB:P91682)
19. [The Drosophila smoothened gene encodes a seven-pass membrane protein, a putative receptor for the hedgehog signal](http://www.ebi.ac.uk/QuickGO/annotations?protein=P91682&geneProductId=UniProtKB:P91682)
20. [Drosophila melanogaster G protein-coupled receptors](http://www.ebi.ac.uk/QuickGO/annotations?protein=P91682&geneProductId=UniProtKB:P91682)
21. [Cilia-mediated hedgehog signaling in Drosophila](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P91682)
22. [Regulation of smoothened by Drosophila G-protein-coupled receptor kinases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P91682)
23. [Hedgehog induces opposite changes in turnover and subcellular localization of patched and smoothened](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P91682)
24. [The extracellular loops of Smoothened play a regulatory role in control of Hedgehog pathway activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P91682)
25. [Transcriptional regulation of atonal required for Drosophila larval eye development by concerted action of eyes absent, sine oculis and hedgehog signaling independent of fused kinase and cubitus interruptus.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P91682)
26. [Bacterial Uracil Modulates Drosophila DUOX-Dependent Gut Immunity via Hedgehog-Induced Signaling Endosomes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P91682)
27. [G protein Galphai functions immediately downstream of Smoothened in Hedgehog signalling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P91682)
28. [Sticking together and sorting things out: adhesion as a force in development](http://www.ebi.ac.uk/QuickGO/annotations?protein=P91682&geneProductId=UniProtKB:P91682)
29. [Smoothened transduces Hedgehog signal by physically interacting with Costal2/Fused complex through its C-terminal tail](http://www.ebi.ac.uk/QuickGO/annotations?protein=P91682&geneProductId=UniProtKB:P91682)
30. [Dual roles for patched in sequestering and transducing Hedgehog](http://www.ebi.ac.uk/QuickGO/annotations?protein=P91682&geneProductId=UniProtKB:P91682)
31. [Hedgehog acts as a somatic stem cell factor in the Drosophila ovary](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P91682)
32. [smoothened encodes a receptor-like serpentine protein required for hedgehog signalling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P91682)
33. [A positive role for patched-smoothened signaling in promoting cell proliferation during normal head development in Drosophila.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P91682)
34. [BMP signaling is required for controlling somatic stem cell self-renewal in the Drosophila ovary](http://www.ebi.ac.uk/QuickGO/annotations?protein=P91682&geneProductId=UniProtKB:P91682)
35. [BMP signaling is required for controlling somatic stem cell self-renewal in the Drosophila ovary](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P91682)
36. [Non-cell autonomous control of apoptosis by ligand-independent Hedgehog signaling in Drosophila](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P91682)
37. [Dampening the signals transduced through hedgehog via microRNA miR-7 facilitates notch-induced tumourigenesis.](http://www.ebi.ac.uk/QuickGO/annotations?protein=P91682&geneProductId=UniProtKB:P91682)
38. [Subdividing cell populations in the developing limbs of Drosophila: do wing veins and leg segments define units of growth control?](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P91682)
39. [Sticking together and sorting things out: adhesion as a force in development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P91682)
40. [Roadkill attenuates Hedgehog responses through degradation of Cubitus interruptus](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P91682)
41. [Evidence for a novel feedback loop in the Hedgehog pathway involving Smoothened and Fused.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P91682)
42. [Spatial Activation of TORC1 Is Regulated by Hedgehog and E2F1 Signaling in the Drosophila Eye.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P91682)
43. [Extracellular signals responsible for spatially regulated proliferation in the differentiating Drosophila eye.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P91682)
44. [Quantitative microscopy of the Drosophila ovary shows multiple niche signals specify progenitor cell fate.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P91682)
45. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?protein=P91682&geneProductId=UniProtKB:P91682)
46. [Dual roles for patched in sequestering and transducing Hedgehog](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P91682)
47. [Drosophila G-protein-coupled receptor kinase 2 regulates cAMP-dependent Hedgehog signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P91682)
48. [G protein-coupled receptor kinase 2 promotes high-level Hedgehog signaling by regulating the active state of Smo through kinase-dependent and kinase-independent mechanisms in Drosophila](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P91682)
49. [Switch of PKA substrates from Cubitus interruptus to Smoothened in the Hedgehog signalosome complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P91682)
50. ensembl Release 106