# SMG6 nonsense mediated mRNA decay factor

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21107304](https://www.wikidata.org/wiki/Q21107304)  
**Source**: https://4ort.xyz/entity/smg6-nonsense-mediated-mrna-decay-factor


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q86US8)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86US8)
5. [Functional conservation of the telomerase protein Est1p in humans](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86US8&geneProductId=UniProtKB:Q86US8)
6. [Telomeric repeat containing RNA and RNA surveillance factors at mammalian chromosome ends](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86US8&geneProductId=UniProtKB:Q86US8)
7. [Protein RNA and protein protein interactions mediate association of human EST1A/SMG6 with telomerase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86US8)
8. [The TPR-containing domain within Est1 homologs exhibits species-specific roles in telomerase interaction and telomere length homeostasis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86US8)
9. [SMG6 interacts with the exon junction complex via two conserved EJC-binding motifs (EBMs) required for nonsense-mediated mRNA decay](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86US8)
10. [Upf1 ATPase-dependent mRNP disassembly is required for completion of nonsense- mediated mRNA decay](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86US8)
11. [Functional conservation of the telomerase protein Est1p in humans](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86US8)
12. [An anchor site-type defect in human telomerase that disrupts telomere length maintenance and cellular immortalization](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86US8&geneProductId=UniProtKB:Q86US8)
13. [Protein RNA and protein protein interactions mediate association of human EST1A/SMG6 with telomerase](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86US8&geneProductId=UniProtKB:Q86US8)
14. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86US8&geneProductId=UniProtKB:Q86US8)
15. [SMG6 is the catalytic endonuclease that cleaves mRNAs containing nonsense codons in metazoan](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86US8&geneProductId=UniProtKB:Q86US8)
16. [SMG6 promotes endonucleolytic cleavage of nonsense mRNA in human cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86US8&geneProductId=UniProtKB:Q86US8)
17. [A human homolog of yeast Est1 associates with telomerase and uncaps chromosome ends when overexpressed](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86US8&geneProductId=UniProtKB:Q86US8)
18. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86US8&geneProductId=UniProtKB:Q86US8)
19. [Telomeric repeat containing RNA and RNA surveillance factors at mammalian chromosome ends](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86US8)
20. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86US8)
21. [A human homolog of yeast Est1 associates with telomerase and uncaps chromosome ends when overexpressed](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86US8)
22. [An anchor site-type defect in human telomerase that disrupts telomere length maintenance and cellular immortalization](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86US8)
23. [SMG6 is the catalytic endonuclease that cleaves mRNAs containing nonsense codons in metazoan](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86US8)
24. [SMG6 promotes endonucleolytic cleavage of nonsense mRNA in human cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86US8)
25. [Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86US8&geneProductId=UniProtKB:Q86US8)
26. [Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86US8)
27. [The human RNA surveillance factor UPF1 is required for S phase progression and genome stability](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86US8)
28. [SMG7 is a 14-3-3-like adaptor in the nonsense-mediated mRNA decay pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86US8)
29. [The human RNA surveillance factor UPF1 is required for S phase progression and genome stability](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86US8&geneProductId=UniProtKB:Q86US8)
30. [SMG6 interacts with the exon junction complex via two conserved EJC-binding motifs (EBMs) required for nonsense-mediated mRNA decay](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86US8&geneProductId=UniProtKB:Q86US8)
31. [Regulation of cellular immortalization and steady-state levels of the telomerase reverse transcriptase through its carboxy-terminal domain](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86US8&geneProductId=UniProtKB:Q86US8)
32. [The TPR-containing domain within Est1 homologs exhibits species-specific roles in telomerase interaction and telomere length homeostasis](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86US8&geneProductId=UniProtKB:Q86US8)
33. [Regulation of cellular immortalization and steady-state levels of the telomerase reverse transcriptase through its carboxy-terminal domain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86US8)
34. Ensembl Release 99