# Small ubiquitin like modifier 1

> mammalian protein found in Homo sapiens

**Wikidata**: [Q7543599](https://www.wikidata.org/wiki/Q7543599)  
**Source**: https://4ort.xyz/entity/small-ubiquitin-like-modifier-1-q7543599


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P63165)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63165)
5. [SUMOylation regulates Kv2.1 and modulates pancreatic beta-cell excitability](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63165)
6. [The DNA topoisomerase I binding protein topors as a novel cellular target for SUMO-1 modification: characterization of domains necessary for subcellular localization and sumolation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63165)
7. [Transcription factor AP-2 interacts with the SUMO-conjugating enzyme UBC9 and is sumolated in vivo](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63165)
8. [SUMOylation and SUMO-interacting Motif (SIM) of Metastasis Tumor Antigen 1 (MTA1) Synergistically Regulate Its Transcriptional Repressor Function](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63165)
9. [The mechanisms of PML-nuclear body formation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63165)
10. [SUMO-1 modification of the acute promyelocytic leukaemia protein PML: implications for nuclear localisation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63165)
11. [Interaction of DJ-1 with Daxx inhibits apoptosis signal-regulating kinase 1 activity and cell death](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63165)
12. [Mammalian SUMO E3-ligases PIAS1 and PIAS4 promote responses to DNA double-strand breaks](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63165)
13. [Elevated level of SUMOylated IRF-1 in tumor cells interferes with IRF-1-mediated apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63165)
14. [One SUMO is sufficient to silence the dimeric potassium channel K2P1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63165)
15. [SUMO protease SENP1 induces isomerization of the scissile peptide bond](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63165)
16. [The SUMO modification pathway is involved in the BRCA1 response to genotoxic stress.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63165)
17. [PARP-1 transcriptional activity is regulated by sumoylation upon heat shock](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63165)
18. [A human interactome in three quantitative dimensions organized by stoichiometries and abundances](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63165)
19. [Structural and Functional Characterization of the Phosphorylation-Dependent Interaction between PML and SUMO1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63165)
20. [Sumoylation of eIF4E activates mRNA translation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63165)
21. [SUMOylation of Blimp-1 is critical for plasma cell differentiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63165)
22. [Cbx4 Governs HIF-1α to Potentiate Angiogenesis of Hepatocellular Carcinoma by Its SUMO E3 Ligase Activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63165)
23. [LUBAC regulates NF-κB activation upon genotoxic stress by promoting linear ubiquitination of NEMO](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63165)
24. [Regulation of MBD1-mediated transcriptional repression by SUMO and PIAS proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63165)
25. [Small ubiquitin-related modifier-1 modification regulates all-trans-retinoic acid-induced differentiation via stabilization of retinoic acid receptor α](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63165)
26. [RSUME, a small RWD-containing protein, enhances SUMO conjugation and stabilizes HIF-1alpha during hypoxia](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63165)
27. [Lens epithelium‐derived growth factor deSumoylation by Sumo‐specific protease‐1 regulates its transcriptional activation of small heat shock protein and the cellular response](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63165)
28. [Listeria monocytogenes impairs SUMOylation for efficient infection](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63165)
29. [Towards a proteome-scale map of the human protein–protein interaction network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63165)
30. [Inducible SUMO modification of TANK alleviates its repression of TLR7 signalling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63165)
31. [Active site remodelling accompanies thioester bond formation in the SUMO E1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63165)
32. [Noncovalent interaction between Ubc9 and SUMO promotes SUMO chain formation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63165)
33. [Distinct and overlapping sets of SUMO-1 and SUMO-2 target proteins revealed by quantitative proteomics](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63165)
34. [Inhibition of androgen receptor activity by histone deacetylase 4 through receptor SUMOylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63165)
35. [Human Cytomegalovirus Infection Causes Degradation of Sp100 Proteins That Suppress Viral Gene Expression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63165)
36. [AXIN is an essential co-activator for the promyelocytic leukemia protein in p53 activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63165)
37. [Synaptonemal complex formation and meiotic checkpoint signaling are linked to the lateral element protein Red1.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63165)
38. [An extended consensus motif enhances the specificity of substrate modification by SUMO](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63165)
39. [Lysine activation and functional analysis of E2-mediated conjugation in the SUMO pathway.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63165)
40. [DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63165)
41. [Sumoylation of the SOX10 transcription factor regulates its transcriptional activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63165)
42. [Structural basis for SENP2 protease interactions with SUMO precursors and conjugated substrates](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63165)
43. [Interaction of Daxx, a Fas binding protein, with sentrin and Ubc9](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63165)
44. [A basis for SUMO protease specificity provided by analysis of human Senp2 and a Senp2-SUMO complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63165)
45. [Ubiquitin-specific protease-like 1 (USPL1) is a SUMO isopeptidase with essential, non-catalytic functions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63165)
46. [PIASy stimulates HIF1α SUMOylation and negatively regulates HIF1α activity in response to hypoxia](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63165)
47. [SUMO conjugation to the matrix attachment region-binding protein, special AT-rich sequence-binding protein-1 (SATB1), targets SATB1 to promyelocytic nuclear bodies where it undergoes caspase cleavage](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63165)
48. [Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63165)
49. [A molecular basis for phosphorylation-dependent SUMO conjugation by the E2 UBC9.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63165)
50. [SUMOylation of Blimp-1 promotes its proteasomal degradation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63165)