# SMAD specific E3 ubiquitin protein ligase 2

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21112471](https://www.wikidata.org/wiki/Q21112471)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/SMURF2)  
**Source**: https://4ort.xyz/entity/smad-specific-e3-ubiquitin-protein-ligase-2


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q9HAU4)
3. Q20641742
4. [SCFFBXL15regulates BMP signalling by directing the degradation of HECT-type ubiquitin ligase Smurf1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HAU4)
5. [Identification of novel Smad2 and Smad3 associated proteins in response to TGF-beta1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HAU4)
6. [Hepatitis C virus infection protein network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HAU4)
7. [Multiple modification and protein interaction signals drive the Ring finger protein 11 (RNF11) E3 ligase to the endosomal compartment](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HAU4)
8. [Functional proteomics mapping of a human signaling pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HAU4)
9. [Structural basis for the versatile interactions of Smad7 with regulator WW domains in TGF-β Pathways](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HAU4)
10. [Coupling of tandem Smad ubiquitination regulatory factor (Smurf) WW domains modulates target specificity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HAU4)
11. [Autoinhibition of the HECT-type ubiquitin ligase Smurf2 through its C2 domain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HAU4)
12. [Ablation of Smurf2 reveals an inhibition in TGF-β signalling through multiple mono-ubiquitination of Smad3](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HAU4)
13. [An RNF11: Smurf2 complex mediates ubiquitination of the AMSH protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HAU4)
14. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9HAU4&geneProductId=UniProtKB:Q9HAU4)
15. [An RNF11: Smurf2 complex mediates ubiquitination of the AMSH protein](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9HAU4&geneProductId=UniProtKB:Q9HAU4)
16. [Maturation of human dendritic cells is accompanied by functional remodelling of the ubiquitin-proteasome system](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9HAU4&geneProductId=UniProtKB:Q9HAU4)
17. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HAU4)
18. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HAU4)
19. [Pin1 down-regulates transforming growth factor-beta (TGF-beta) signaling by inducing degradation of Smad proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HAU4)
20. [Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HAU4)
21. [Smurf2 participates in human trophoblast cell invasion by inhibiting TGF-beta type I receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HAU4)
22. [Pin1 down-regulates transforming growth factor-beta (TGF-beta) signaling by inducing degradation of Smad proteins](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9HAU4&geneProductId=UniProtKB:Q9HAU4)
23. [Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HAU4)
24. [Smurf2 is a ubiquitin E3 ligase mediating proteasome-dependent degradation of Smad2 in transforming growth factor-beta signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HAU4)
25. Ensembl Release 99