# SMAD specific E3 ubiquitin protein ligase 1

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21112473](https://www.wikidata.org/wiki/Q21112473)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/SMURF1)  
**Source**: https://4ort.xyz/entity/smad-specific-e3-ubiquitin-protein-ligase-1


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q9HCE7)
3. Q20641742
4. [Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HCE7)
5. [Smurf1 regulates the inhibitory activity of Smad7 by targeting Smad7 to the plasma membrane](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HCE7)
6. [FKBP12 functions as an adaptor of the Smad7-Smurf1 complex on activin type I receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HCE7)
7. [SCFFBXL15regulates BMP signalling by directing the degradation of HECT-type ubiquitin ligase Smurf1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HCE7)
8. [Ubiquitin ligase Smurf1 targets TRAF family proteins for ubiquitination and degradation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HCE7)
9. [Image-based genome-wide siRNA screen identifies selective autophagy factors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HCE7)
10. [REGgamma proteasome mediates degradation of the ubiquitin ligase Smurf1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HCE7)
11. [Functional proteomics mapping of a human signaling pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HCE7)
12. [Nuclear CDKs drive Smad transcriptional activation and turnover in BMP and TGF-beta pathways](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HCE7)
13. [Smurf1 ubiquitin ligase targets Kruppel-like factor KLF2 for ubiquitination and degradation in human lung cancer H1299 cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HCE7)
14. [CKIP‐1 couples Smurf1 ubiquitin ligase with Rpt6 subunit of proteasome to promote substrate degradation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HCE7)
15. [ATR/Chk1/Smurf1 pathway determines cell fate after DNA damage by controlling RhoB abundance](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HCE7)
16. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HCE7)
17. [A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HCE7)
18. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9HCE7&geneProductId=UniProtKB:Q9HCE7)
19. [Smurf1 regulates the inhibitory activity of Smad7 by targeting Smad7 to the plasma membrane](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9HCE7&geneProductId=UniProtKB:Q9HCE7)
20. [Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradation](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9HCE7&geneProductId=UniProtKB:Q9HCE7)
21. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HCE7)
22. [SCFFBXL15regulates BMP signalling by directing the degradation of HECT-type ubiquitin ligase Smurf1](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9HCE7&geneProductId=UniProtKB:Q9HCE7)
23. [Large-scale proteomics and phosphoproteomics of urinary exosomes](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9HCE7&geneProductId=UniProtKB:Q9HCE7)
24. [Large-scale proteomics and phosphoproteomics of urinary exosomes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HCE7)
25. [Ubiquitin ligase Smurf1 targets TRAF family proteins for ubiquitination and degradation](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9HCE7&geneProductId=UniProtKB:Q9HCE7)
26. [The E3 Ligase Smurf1 Regulates Wolfram Syndrome Protein Stability at the Endoplasmic Reticulum](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HCE7)
27. [SYT14L, especially its C2 domain, is involved in regulating melanocyte differentiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HCE7)
28. [A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9HCE7&geneProductId=UniProtKB:Q9HCE7)
29. [MicroRNA-140-5p and SMURF1 regulate pulmonary arterial hypertension](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9HCE7&geneProductId=UniProtKB:Q9HCE7)
30. [MicroRNA-140-5p and SMURF1 regulate pulmonary arterial hypertension](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HCE7)
31. Ensembl Release 99