# SMAD family member 7

> mammalian protein found in Homo sapiens

**Wikidata**: [Q6917578](https://www.wikidata.org/wiki/Q6917578)  
**Source**: https://4ort.xyz/entity/smad-family-member-7


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/O15105)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15105)
5. [Smad7 stabilizes beta-catenin binding to E-cadherin complex and promotes cell-cell adhesion](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15105)
6. [Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15105)
7. [Vascular MAD s: Two novel MAD -related genes selectively inducible by flow in human vascular endothelium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15105)
8. [FKBP12 functions as an adaptor of the Smad7-Smurf1 complex on activin type I receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15105)
9. [USP15 stabilizes TGF-β receptor I and promotes oncogenesis through the activation of TGF-β signaling in glioblastoma](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15105)
10. [Selective targeting of activating and inhibitory Smads by distinct WWP2 ubiquitin ligase isoforms differentially modulates TGFβ signalling and EMT](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15105)
11. [Jab1/CSN5, a component of the COP9 signalosome, regulates transforming growth factor beta signaling by binding to Smad7 and promoting its degradation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15105)
12. [Structural basis for the versatile interactions of Smad7 with regulator WW domains in TGF-β Pathways](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15105)
13. [Functional proteomics mapping of a human signaling pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15105)
14. [Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15105)
15. [Ligand binding to WW tandem domains of YAP2 transcriptional regulator is under negative cooperativity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15105)
16. [Coupling of tandem Smad ubiquitination regulatory factor (Smurf) WW domains modulates target specificity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15105)
17. [Smad7 is inactivated through a direct physical interaction with the LIM protein Hic-5/ARA55](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15105)
18. [Smurf1 regulates the inhibitory activity of Smad7 by targeting Smad7 to the plasma membrane](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15105)
19. [Smad7 antagonizes transforming growth factor beta signaling in the nucleus by interfering with functional Smad-DNA complex formation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15105)
20. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=O15105&geneProductId=UniProtKB:O15105)
21. [Rnf165/Ark2C Enhances BMP-Smad Signaling to Mediate Motor Axon Extension](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15105)
22. [Smad7 is required for the development and function of the heart](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15105)
23. [miR-21 overexpression enhances TGF-β1-induced epithelial-to-mesenchymal transition by target smad7 and aggravates renal damage in diabetic nephropathy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15105)
24. [Holding their own: the noncanonical roles of Smad proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15105)
25. Ensembl Release 99
26. UMLS 2023