# SMAD family member 6

> mammalian protein found in Homo sapiens

**Wikidata**: [Q14904318](https://www.wikidata.org/wiki/Q14904318)  
**Source**: https://4ort.xyz/entity/smad-family-member-6-q14904318


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/O43541)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43541)
5. [Vascular MAD s: Two novel MAD -related genes selectively inducible by flow in human vascular endothelium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43541)
6. [Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43541)
7. [Smad6 is a protein kinase X phosphorylation substrate and is required for HL-60 cell differentiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43541)
8. [Smad6 interacts with Runx2 and mediates Smad ubiquitin regulatory factor 1-induced Runx2 degradation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43541)
9. [Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43541)
10. [Holding their own: the noncanonical roles of Smad proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43541)
11. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=O43541&geneProductId=UniProtKB:O43541)
12. [Rnf165/Ark2C Enhances BMP-Smad Signaling to Mediate Motor Axon Extension](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43541)
13. [SMAD6 contributes to patient survival in non-small cell lung cancer and its knockdown reestablishes TGF-beta homeostasis in lung cancer cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43541)
14. [Fine-tuning BMP7 signalling in adipogenesis by UBE2O/E2-230K-mediated monoubiquitination of SMAD6](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43541)
15. [Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor](http://www.ebi.ac.uk/QuickGO/annotations?protein=O43541&geneProductId=UniProtKB:O43541)
16. [Association of polymorphisms of IGF1R and genes in the transforming growth factor- beta /bone morphogenetic protein pathway with bacteremia in sickle cell anemia](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43541)
17. [Nonsynonymous variants in the SMAD6 gene predispose to congenital cardiovascular malformation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43541)
18. [MicroRNA-155 modulates the interleukin-1 signaling pathway in activated human monocyte-derived dendritic cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43541)
19. Ensembl Release 99