# SMAD family member 4

> mammalian protein found in Homo sapiens

**Wikidata**: [Q408179](https://www.wikidata.org/wiki/Q408179)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/SMAD4)  
**Source**: https://4ort.xyz/entity/smad-family-member-4


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q13485)
3. Q20641742
4. Freebase Data Dumps. 2013
5. [Receptor-associated Mad homologues synergize as effectors of the TGF-beta response](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13485)
6. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13485)
7. [Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13485)
8. [Smad7 antagonizes transforming growth factor beta signaling in the nucleus by interfering with functional Smad-DNA complex formation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13485)
9. [Transforming growth factor beta -inducible independent binding of SMAD to the Smad7 promoter](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13485)
10. [HMGA2 and Smads co-regulate SNAIL1 expression during induction of epithelial-to-mesenchymal transition](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13485)
11. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13485&geneProductId=UniProtKB:Q13485)
12. [Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13485&geneProductId=UniProtKB:Q13485)
13. [Vascular MAD s: Two novel MAD -related genes selectively inducible by flow in human vascular endothelium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13485)
14. [Homeoprotein DLX-1 interacts with Smad4 and blocks a signaling pathway from activin A in hematopoietic cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13485)
15. [Potentiation of Smad-mediated transcriptional activation by the RNA-binding protein RBPMS](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13485)
16. [Involvement of the constitutive complex formation of c-Ski/SnoN with Smads in the impaired negative feedback regulation of transforming growth factor beta signaling in scleroderma fibroblasts](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13485)
17. [TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13485)
18. [Transforming growth factor-beta receptor-associated protein 1 is a Smad4 chaperone](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13485)
19. [Sustained Induction of Collagen Synthesis by TGF-β Requires Regulated Intramembrane Proteolysis of CREB3L1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13485)
20. [Transcriptional activating activity of Smad4: roles of SMAD hetero-oligomerization and enhancement by an associating transactivator](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13485)
21. [Mutations in nuclear pore genes NUP93, NUP205 and XPO5 cause steroid-resistant nephrotic syndrome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13485)
22. [FAM/USP9x, a deubiquitinating enzyme essential for TGFbeta signaling, controls Smad4 monoubiquitination](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13485)
23. [Pokemon (FBI-1) interacts with Smad4 to repress TGF-β-induced transcriptional responses](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13485)
24. [DACH1 inhibits transforming growth factor-beta signaling through binding Smad4](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13485)
25. [Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13485)
26. [Control of prostate cell growth: BMP antagonizes androgen mitogenic activity with incorporation of MAPK signals in Smad1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13485)
27. [A proteome-scale map of the human interactome network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13485)
28. [TIF1gamma controls erythroid cell fate by regulating transcription elongation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13485)
29. [Structural mechanism of Smad4 recognition by the nuclear oncoprotein Ski: insights on Ski-mediated repression of TGF-beta signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13485)
30. [Identification of novel Smad2 and Smad3 associated proteins in response to TGF-beta1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13485)
31. [Analysis of protein-protein interactions in cross-talk pathways reveals CRKL protein as a novel prognostic marker in hepatocellular carcinoma](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13485)
32. [Inhibiting Drivers of Non-mutational Drug Tolerance Is a Salvage Strategy for Targeted Melanoma Therapy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13485)
33. [Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13485)
34. [The protein interaction landscape of the human CMGC kinase group](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13485)
35. [Charting the molecular links between driver and susceptibility genes in colorectal cancer](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13485)
36. [Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13485)
37. [Identification of PCTA, a TGIF antagonist that promotes PML function in TGF-beta signalling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13485)
38. [Ski co-repressor complexes maintain the basal repressed state of the TGF-beta target gene, SMAD7, via HDAC3 and PRMT5](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13485)
39. [Nodal enhances the activity of FoxO3a and its synergistic interaction with Smads to regulate cyclin G2 transcription in ovarian cancer cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13485)
40. [Intercellular variation in signaling through the TGF-β pathway and its relation to cell density and cell cycle phase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13485)
41. [Homeodomain protein DLX4 counteracts key transcriptional control mechanisms of the TGF-β cytostatic program and blocks the antiproliferative effect of TGF-β](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13485)
42. [Antagonistic regulation of EMT by TIF1γ and Smad4 in mammary epithelial cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13485)
43. [Ablation of Smurf2 reveals an inhibition in TGF-β signalling through multiple mono-ubiquitination of Smad3](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13485)
44. [Widespread macromolecular interaction perturbations in human genetic disorders](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13485)
45. [Structural basis of heteromeric smad protein assembly in TGF-beta signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13485)
46. [Toward an understanding of the protein interaction network of the human liver](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13485)
47. [Pooled-matrix protein interaction screens using Barcode Fusion Genetics](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13485)
48. [Towards a proteome-scale map of the human protein–protein interaction network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13485)
49. [Structural Basis of Smad1 Activation by Receptor Kinase Phosphorylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13485)
50. [Functional proteomics mapping of a human signaling pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13485)