# SMAD family member 4

> mammalian protein found in Mus musculus

**Wikidata**: [Q14904159](https://www.wikidata.org/wiki/Q14904159)  
**Source**: https://4ort.xyz/entity/smad-family-member-4-q14904159


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P97471)
3. Q20641742
4. [Induction of vascular smooth muscle alpha-actin gene transcription in transforming growth factor beta1-activated myofibroblasts mediated by dynamic interplay between the Pur repressor proteins and Sp1/Smad coactivators](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97471)
5. [Smicl is a novel Smad interacting protein and cleavage and polyadenylation specificity factor associated protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97471)
6. [Activin regulation of the follicle-stimulating hormone beta-subunit gene involves Smads and the TALE homeodomain proteins Pbx1 and Prep1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97471)
7. [Disruption of transforming growth factor-beta signaling in ELF beta-spectrin-deficient mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97471)
8. [Intercellular variation in signaling through the TGF-β pathway and its relation to cell density and cell cycle phase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97471)
9. [Ablation of Smurf2 reveals an inhibition in TGF-β signalling through multiple mono-ubiquitination of Smad3](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97471)
10. [Master transcription factors determine cell-type-specific responses to TGF-β signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97471)
11. [HEART DEVELOPMENT. Integration of Bmp and Wnt signaling by Hopx specifies commitment of cardiomyoblasts](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97471)
12. [IKKalpha is a critical coregulator of a Smad4-independent TGFbeta-Smad2/3 signaling pathway that controls keratinocyte differentiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97471)
13. [Reversing SKI-SMAD4-mediated suppression is essential for TH17 cell differentiation.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97471)
14. [Chromatin-bound p53 anchors activated Smads and the mSin3A corepressor to confer transforming-growth-factor-beta-mediated transcription repression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97471)
15. [A direct intersection between p53 and transforming growth factor beta pathways targets chromatin modification and transcription repression of the alpha-fetoprotein gene](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97471)
16. [Structural basis for the cooperative DNA recognition by Smad4 MH1 dimers](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97471)
17. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97471)
18. [Interaction of Smads with collagen types I, III, and V](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97471)
19. [Ecsit is required for Bmp signaling and mesoderm formation during mouse embryogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97471)
20. [The gonadotropin releasing hormone (GnRH) receptor activating sequence (GRAS) is a composite regulatory element that interacts with multiple classes of transcription factors including Smads, AP-1 and a forkhead DNA binding protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97471)
21. [Isl1Cre reveals a common Bmp pathway in heart and limb development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97471)
22. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P97471&geneProductId=UniProtKB:P97471)
23. [A phylogenetically conserved cis-regulatory module in the Msx2 promoter is sufficient for BMP-dependent transcription in murine and Drosophila embryos](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97471)
24. [Regulation of Hex gene expression by a Smads-dependent signaling pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97471)
25. [Transcription factor genes Smad4 and Gata4 cooperatively regulate cardiac valve development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97471)
26. [Transcription factor genes Smad4 and Gata4 cooperatively regulate cardiac valve development](http://www.ebi.ac.uk/QuickGO/annotations?protein=P97471&geneProductId=UniProtKB:P97471)
27. [Transforming growth factor beta1 signaling via interaction with cell surface Hyal-2 and recruitment of WWOX/WOX1](http://www.ebi.ac.uk/QuickGO/annotations?protein=P97471&geneProductId=UniProtKB:P97471)
28. [Transforming growth factor beta1 signaling via interaction with cell surface Hyal-2 and recruitment of WWOX/WOX1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97471)
29. [Lhx1 functions together with Otx2, Foxa2, and Ldb1 to govern anterior mesendoderm, node, and midline development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97471)
30. [TGFbeta3 signaling activates transcription of the LEF1 gene to induce epithelial mesenchymal transformation during mouse palate development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97471)
31. [Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97471)
32. [Smad4-dependent desmoglein-4 expression contributes to hair follicle integrity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97471)
33. [Smad4 and FAST-1 in the assembly of activin-responsive factor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97471)
34. [Differential requirements for Smad4 in TGFbeta-dependent patterning of the early mouse embryo](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97471)
35. [Intestinal tumorigenesis in compound mutant mice of both Dpc4 (Smad4) and Apc genes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97471)
36. [Gastrointestinal tumorigenesis in Smad4 (Dpc4) mutant mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97471)
37. [Gastric and duodenal polyps in Smad4 (Dpc4) knockout mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97471)
38. [Glypican-3 modulates inhibitory Bmp2-Smad signaling to control renal development in vivo](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97471)
39. [Retrograde BMP signaling regulates trigeminal sensory neuron identities and the formation of precise face maps](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97471)
40. [Proper formation of whisker barrelettes requires periphery-derived Smad4-dependent TGF-β signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97471)
41. [Follicle‐stimulating hormone synthesis and fertility depend on SMAD4 and FOXL2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97471)
42. [The tumor suppressor gene Smad4/Dpc4 is required for gastrulation and later for anterior development of the mouse embryo](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97471)
43. [TGFbeta superfamily signals are required for morphogenesis of the kidney mesenchyme progenitor population](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97471)
44. [A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97471)
45. [BMP signaling regulates sympathetic nervous system development through Smad4-dependent and -independent pathways](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97471)
46. [Targeted disruption of Smad4 in cardiomyocytes results in cardiac hypertrophy and heart failure](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97471)
47. [Iron regulates phosphorylation of Smad1/5/8 and gene expression of Bmp6, Smad7, Id1, and Atoh8 in the mouse liver](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97471)
48. [Smad4 is required to induce digit ray primordia and to initiate the aggregation and differentiation of chondrogenic progenitors in mouse limb buds](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97471)
49. [Gastro-intestinal tumorigenesis in Smad4 mutant mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97471)
50. [Cyclooxygenase 2- and prostaglandin E(2) receptor EP(2)-dependent angiogenesis in Apc(Delta716) mouse intestinal polyps](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97471)