# SMAD family member 3

> mammalian protein found in Homo sapiens

**Wikidata**: [Q6917575](https://www.wikidata.org/wiki/Q6917575)  
**Source**: https://4ort.xyz/entity/smad-family-member-3


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P84022)
3. Q20641742
4. [PPM1A functions as a Smad phosphatase to terminate TGFbeta signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P84022)
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P84022)
6. [USP15 is a deubiquitylating enzyme for receptor-activated SMADs](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P84022)
7. [Heteromeric and homomeric interactions correlate with signaling activity and functional cooperativity of Smad3 and Smad4/DPC4](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P84022)
8. [Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-β-induced transcription](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P84022)
9. [Transforming growth factor beta -inducible independent binding of SMAD to the Smad7 promoter](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P84022)
10. [TMEPAI, a transmembrane TGF-beta-inducible protein, sequesters Smad proteins from active participation in TGF-beta signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P84022)
11. [TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P84022)
12. [Receptor-associated Mad homologues synergize as effectors of the TGF-beta response](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P84022)
13. [HEB and E2A function as SMAD/FOXH1 cofactors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P84022)
14. [Features of a Smad3 MH1-DNA complex. Roles of water and zinc in DNA binding](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P84022)
15. [HMGA2 and Smads co-regulate SNAIL1 expression during induction of epithelial-to-mesenchymal transition](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P84022)
16. [Cloning and functional characterization of a new Ski homolog, Fussel-18, specifically expressed in neuronal tissues](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P84022)
17. [SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P84022)
18. [C18 ORF1, a novel negative regulator of transforming growth factor-β signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P84022)
19. [Identification and characterization of a PDZ protein that interacts with activin type II receptors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P84022)
20. [Potentiation of Smad-mediated transcriptional activation by the RNA-binding protein RBPMS](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P84022)
21. [Hsp70 and Hsp90 oppositely regulate TGF-β signaling through CHIP/Stub1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P84022)
22. [Involvement of the constitutive complex formation of c-Ski/SnoN with Smads in the impaired negative feedback regulation of transforming growth factor beta signaling in scleroderma fibroblasts](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P84022)
23. [TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P84022)
24. [Roles of pathway-specific and inhibitory Smads in activin receptor signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P84022)
25. [Nuclear export of Smad2 and Smad3 by RanBP3 facilitates termination of TGF-beta signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P84022)
26. [Oligomerization of Evi-1 regulated by the PR domain contributes to recruitment of corepressor CtBP](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P84022)
27. [The Smad3 linker region contains a transcriptional activation domain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P84022)
28. [The integral inner nuclear membrane protein MAN1 physically interacts with the R-Smad proteins to repress signaling by the transforming growth factor-{beta} superfamily of cytokines](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P84022)
29. [Fussel-15, a novel Ski/Sno homolog protein, antagonizes BMP signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P84022)
30. [SKI and MEL1 cooperate to inhibit transforming growth factor-beta signal in gastric cancer cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P84022)
31. [Inactivation of menin, a Smad3-interacting protein, blocks transforming growth factor type beta signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P84022)
32. [Hepatitis C virus core variants isolated from liver tumor but not from adjacent non-tumor tissue interact with Smad3 and inhibit the TGF-beta pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P84022)
33. [Functional proteomics mapping of a human signaling pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P84022)
34. [Antagonistic regulation of EMT by TIF1γ and Smad4 in mammary epithelial cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P84022)
35. [ShcA Protects against Epithelial-Mesenchymal Transition through Compartmentalized Inhibition of TGF-β-Induced Smad Activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P84022)
36. [MiR-1 suppresses tumor cell proliferation in colorectal cancer by inhibition of Smad3-mediated tumor glycolysis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P84022)
37. [Nodal enhances the activity of FoxO3a and its synergistic interaction with Smads to regulate cyclin G2 transcription in ovarian cancer cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P84022)
38. [Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P84022)
39. [Ski-interacting protein interacts with Smad proteins to augment transforming growth factor-beta-dependent transcription](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P84022)
40. [Smad3 allostery links TGF-beta receptor kinase activation to transcriptional control](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P84022)
41. [Ablation of Smurf2 reveals an inhibition in TGF-β signalling through multiple mono-ubiquitination of Smad3](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P84022)
42. [Ski co-repressor complexes maintain the basal repressed state of the TGF-beta target gene, SMAD7, via HDAC3 and PRMT5](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P84022)
43. [Homeodomain protein DLX4 counteracts key transcriptional control mechanisms of the TGF-β cytostatic program and blocks the antiproliferative effect of TGF-β](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P84022)
44. [DACH1 inhibits transforming growth factor-beta signaling through binding Smad4](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P84022)
45. [SMAD proteins control DROSHA-mediated microRNA maturation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P84022)
46. [FAM/USP9x, a deubiquitinating enzyme essential for TGFbeta signaling, controls Smad4 monoubiquitination](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P84022)
47. [Identification of novel Smad2 and Smad3 associated proteins in response to TGF-beta1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P84022)
48. [Selective targeting of activating and inhibitory Smads by distinct WWP2 ubiquitin ligase isoforms differentially modulates TGFβ signalling and EMT](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P84022)
49. [LuTHy: a double-readout bioluminescence-based two-hybrid technology for quantitative mapping of protein-protein interactions in mammalian cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P84022)
50. [Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein–Protein Interactions in a Pathway Network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P84022)