# SMAD family member 3

> mammalian protein found in Rattus norvegicus

**Wikidata**: [Q28560952](https://www.wikidata.org/wiki/Q28560952)  
**Source**: https://4ort.xyz/entity/smad-family-member-3-q28560952


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P84025)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P84025)
5. [cAMP inhibits transforming growth factor-beta-stimulated collagen synthesis via inhibition of extracellular signal-regulated kinase 1/2 and Smad signaling in cardiac fibroblasts](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P84025)
6. [Smad3 mediates transforming growth factor-beta-induced alpha-smooth muscle actin expression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P84025)
7. [Cited2 modulates TGF-beta-mediated upregulation of MMP9](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P84025)
8. [Novel roles of Akt and mTOR in suppressing TGF-beta/ALK5-mediated Smad3 activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P84025)
9. [Smad3 prevents beta-catenin degradation and facilitates beta-catenin nuclear translocation in chondrocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P84025)
10. [Pharmacological application of caffeine inhibits TGF-beta-stimulated connective tissue growth factor expression in hepatocytes via PPARgamma and SMAD2/3-dependent pathways](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P84025)
11. [Gut-enriched Krüppel-like factor interaction with Smad3 inhibits myofibroblast differentiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P84025)
12. [Poly(ADP-ribose) Polymerase 1 Is Indispensable for Transforming Growth Factor-β Induced Smad3 Activation in Vascular Smooth Muscle Cell](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P84025)
13. [Requirement of Smad3 and CREB-1 in mediating transforming growth factor-beta (TGF beta) induction of TGF beta 3 secretion](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P84025)
14. [Role of Smad3 in the regulation of rat telomerase reverse transcriptase by TGFbeta](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P84025)
15. [Reversible Smad-dependent signaling between tumor suppression and oncogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P84025)
16. [Autocrine loop between TGF-beta1 and IL-1beta through Smad3- and ERK-dependent pathways in rat pancreatic stellate cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P84025)
17. [Smad2 and Smad3 play different roles in rat hepatic stellate cell function and alpha-smooth muscle actin organization](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P84025)
18. [Smad3 promotes alkaline phosphatase activity and mineralization of osteoblastic MC3T3-E1 cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P84025)
19. [Activin signal transduction in the fetal rat adrenal gland and in human H295R cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P84025)
20. [Parathyroid Hormone-Smad3 Axis Exerts Anti-apoptotic Action and Augments Anabolic Action of Transforming Growth Factor β in Osteoblasts](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P84025)
21. [MiRNA-199a-5p influences pulmonary artery hypertension via downregulating Smad3](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P84025)
22. [Transforming growth factor beta 1 induces apoptosis through cleavage of BAD in a Smad3-dependent mechanism in FaO hepatoma cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P84025)
23. ensembl Release 106