# SMAD family member 3

> mammalian protein found in Mus musculus

**Wikidata**: [Q14903978](https://www.wikidata.org/wiki/Q14903978)  
**Source**: https://4ort.xyz/entity/smad-family-member-3-q14903978


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q8BUN5)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BUN5)
5. [The gonadotropin releasing hormone (GnRH) receptor activating sequence (GRAS) is a composite regulatory element that interacts with multiple classes of transcription factors including Smads, AP-1 and a forkhead DNA binding protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BUN5)
6. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8BUN5&geneProductId=UniProtKB:Q8BUN5)
7. [Galectin-9-CD44 interaction enhances stability and function of adaptive regulatory T cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BUN5)
8. [The role of a Williams-Beuren syndrome-associated helix-loop-helix domain-containing transcription factor in activin/nodal signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BUN5)
9. [Structural basis for the cooperative DNA recognition by Smad4 MH1 dimers](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BUN5)
10. [Interaction of Smads with collagen types I, III, and V](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BUN5)
11. [Cited2 modulates TGF-beta-mediated upregulation of MMP9](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BUN5)
12. [PRDM16/MEL1: a novel Smad binding protein expressed in murine embryonic orofacial tissue](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BUN5)
13. [Ttrap is an essential modulator of Smad3-dependent Nodal signaling during zebrafish gastrulation and left-right axis determination](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BUN5)
14. [Response gene to complement 32 is essential for fibroblast activation in renal fibrosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BUN5)
15. [TGF-beta inhibits muscle differentiation through functional repression of myogenic transcription factors by Smad3](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BUN5)
16. [Activin regulation of the follicle-stimulating hormone beta-subunit gene involves Smads and the TALE homeodomain proteins Pbx1 and Prep1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BUN5)
17. [Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BUN5)
18. [Induction of vascular smooth muscle alpha-actin gene transcription in transforming growth factor beta1-activated myofibroblasts mediated by dynamic interplay between the Pur repressor proteins and Sp1/Smad coactivators](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BUN5)
19. [Disruption of transforming growth factor-beta signaling in ELF beta-spectrin-deficient mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BUN5)
20. [Transposon mutagenesis with coat color genotyping identifies an essential role for Skor2 in sonic hedgehog signaling and cerebellum development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BUN5)
21. [Repression of Runx2 function by TGF-beta through recruitment of class II histone deacetylases by Smad3.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BUN5)
22. [Functional interaction between Smad, CREB binding protein, and p68 RNA helicase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BUN5)
23. [Menin is required for bone morphogenetic protein 2- and transforming growth factor beta-regulated osteoblastic differentiation through interaction with Smads and Runx2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BUN5)
24. [Intercellular variation in signaling through the TGF-β pathway and its relation to cell density and cell cycle phase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BUN5)
25. [IKKalpha is a critical coregulator of a Smad4-independent TGFbeta-Smad2/3 signaling pathway that controls keratinocyte differentiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BUN5)
26. [Ablation of Smurf2 reveals an inhibition in TGF-β signalling through multiple mono-ubiquitination of Smad3](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BUN5)
27. [Master transcription factors determine cell-type-specific responses to TGF-β signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BUN5)
28. [Myocardin enhances Smad3-mediated transforming growth factor-beta1 signaling in a CArG box-independent manner: Smad-binding element is an important cis element for SM22alpha transcription in vivo](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BUN5)
29. [A novel role for cardiac ankyrin repeat protein Ankrd1/CARP as a co-activator of the p53 tumor suppressor protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BUN5)
30. [Pin1 promotes degradation of Smad proteins and their interaction with phosphorylated tau in Alzheimer's disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BUN5)
31. [Smad proteins function as co-modulators for MEF2 transcriptional regulatory proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BUN5)
32. [Smad2 and Smad3 coordinately regulate craniofacial and endodermal development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BUN5)
33. [Smad expression during kidney development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BUN5)
34. [Transforming growth factor beta -inducible independent binding of SMAD to the Smad7 promoter](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BUN5)
35. [Loss of Smad3 gives rise to poor soft callus formation and accelerates early fracture healing](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BUN5)
36. [Mice lacking Smad3 show accelerated wound healing and an impaired local inflammatory response](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BUN5)
37. [Role of Smad3 in the hormonal modulation of in vivo wound healing responses](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BUN5)
38. [Receptor-associated Mad homologues synergize as effectors of the TGF-beta response](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BUN5)
39. [RLP, a novel Ras-like protein, is an immediate-early transforming growth factor-beta (TGF-beta) target gene that negatively regulates transcriptional activity induced by TGF-beta](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BUN5)
40. [TGF-β/Smad2/3 signaling directly regulates several miRNAs in mouse ES cells and early embryos](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BUN5)
41. [Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-beta](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BUN5)
42. [Smad2 and Smad3 positively and negatively regulate TGF beta-dependent transcription through the forkhead DNA-binding protein FAST2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BUN5)
43. [The anaphase-promoting complex coordinates initiation of lens differentiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BUN5)
44. [The loss of Smad3 results in a lower rate of bone formation and osteopenia through dysregulation of osteoblast differentiation and apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BUN5)
45. [Combinatorial activities of Smad2 and Smad3 regulate mesoderm formation and patterning in the mouse embryo](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BUN5)
46. [Smad 3 regulates proliferation of the mouse ovarian surface epithelium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BUN5)
47. [DeltaEF1 mediates TGF-beta signaling in vascular smooth muscle cell differentiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BUN5)
48. [Essential function of HIPK2 in TGFbeta-dependent survival of midbrain dopamine neurons](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BUN5)
49. ensembl Release 106