# SMAD family member 2

> mammalian protein found in Mus musculus

**Wikidata**: [Q14903951](https://www.wikidata.org/wiki/Q14903951)  
**Source**: https://4ort.xyz/entity/smad-family-member-2


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q62432)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62432)
5. [Structural basis for the cooperative DNA recognition by Smad4 MH1 dimers](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62432)
6. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62432&geneProductId=UniProtKB:Q62432)
7. [The role of a Williams-Beuren syndrome-associated helix-loop-helix domain-containing transcription factor in activin/nodal signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62432)
8. [Smad2 and Smad3 positively and negatively regulate TGF beta-dependent transcription through the forkhead DNA-binding protein FAST2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62432)
9. [A direct intersection between p53 and transforming growth factor beta pathways targets chromatin modification and transcription repression of the alpha-fetoprotein gene](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62432)
10. [Cited2 modulates TGF-beta-mediated upregulation of MMP9](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62432)
11. [Activin regulation of the follicle-stimulating hormone beta-subunit gene involves Smads and the TALE homeodomain proteins Pbx1 and Prep1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62432)
12. [Induction of vascular smooth muscle alpha-actin gene transcription in transforming growth factor beta1-activated myofibroblasts mediated by dynamic interplay between the Pur repressor proteins and Sp1/Smad coactivators](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62432)
13. [Smicl is a novel Smad interacting protein and cleavage and polyadenylation specificity factor associated protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62432)
14. [Identification of novel Smad binding proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62432)
15. [Intercellular variation in signaling through the TGF-β pathway and its relation to cell density and cell cycle phase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62432)
16. [Smad proteins function as co-modulators for MEF2 transcriptional regulatory proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62432)
17. [Pin1 promotes degradation of Smad proteins and their interaction with phosphorylated tau in Alzheimer's disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62432)
18. [TGFbeta3 signaling activates transcription of the LEF1 gene to induce epithelial mesenchymal transformation during mouse palate development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62432)
19. [Foxh1 recruits Gsc to negatively regulate Mixl1 expression during early mouse development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62432)
20. [Proper formation of whisker barrelettes requires periphery-derived Smad4-dependent TGF-β signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62432)
21. [Genetic interactions between activin type IIB receptor and Smad2 genes in asymmetrical patterning of the thoracic organs and the development of pancreas islets](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62432)
22. [Combinatorial activities of Smad2 and Smad3 regulate mesoderm formation and patterning in the mouse embryo](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62432)
23. [Cell fate decisions within the mouse organizer are governed by graded Nodal signals](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62432)
24. [Smad2 and Smad3 coordinately regulate craniofacial and endodermal development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62432)
25. [Endogenous TGF-beta signaling suppresses maturation of osteoblastic mesenchymal cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62432)
26. [Epithelial and ectomesenchymal role of the type I TGF-beta receptor ALK5 during facial morphogenesis and palatal fusion](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62432)
27. [TGF-β/Smad2/3 signaling directly regulates several miRNAs in mouse ES cells and early embryos](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62432)
28. [Smad expression during kidney development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62432)
29. [Whole-genome microRNA screening identifies let-7 and mir-18 as regulators of germ layer formation during early embryogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62432)
30. [The T-box transcription factor Eomesodermin acts upstream of Mesp1 to specify cardiac mesoderm during mouse gastrulation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62432)
31. [Chromatin-bound p53 anchors activated Smads and the mSin3A corepressor to confer transforming-growth-factor-beta-mediated transcription repression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62432)
32. [Antagonistic effects of Smad2 versus Smad7 are sensitive to their expression level during tooth development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62432)
33. [Nodal signalling in the epiblast patterns the early mouse embryo](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62432)
34. [Smad2 Signaling in Extraembryonic Tissues Determines Anterior-Posterior Polarity of the Early Mouse Embryo](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62432)
35. [Essential function of HIPK2 in TGFbeta-dependent survival of midbrain dopamine neurons](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62432)
36. [Mesodermal deletion of transforming growth factor-beta receptor II disrupts lung epithelial morphogenesis: cross-talk between TGF-beta and Sonic hedgehog pathways](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62432)
37. ensembl Release 106
38. [Identifiers.org](https://registry.identifiers.org/registry/uniprot)