# SMAD family member 2

> mammalian protein found in Homo sapiens

**Wikidata**: [Q6917574](https://www.wikidata.org/wiki/Q6917574)  
**Source**: https://4ort.xyz/entity/smad-family-member-2-q6917574


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q15796)
3. Q20641742
4. [PPM1A functions as a Smad phosphatase to terminate TGFbeta signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15796)
5. [Vascular MAD s: Two novel MAD -related genes selectively inducible by flow in human vascular endothelium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15796)
6. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15796)
7. [Smad7 antagonizes transforming growth factor beta signaling in the nucleus by interfering with functional Smad-DNA complex formation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15796)
8. [Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15796)
9. [Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15796&geneProductId=UniProtKB:Q15796)
10. [TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15796)
11. [Heteromeric and homomeric interactions correlate with signaling activity and functional cooperativity of Smad3 and Smad4/DPC4](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15796)
12. [Characterization of Human FAST-1, a TGFβ and Activin Signal Transducer](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15796)
13. [MADR2 is a substrate of the TGFbeta receptor and its phosphorylation is required for nuclear accumulation and signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15796)
14. [Cloning and functional characterization of a new Ski homolog, Fussel-18, specifically expressed in neuronal tissues](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15796)
15. [SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15796)
16. [C18 ORF1, a novel negative regulator of transforming growth factor-β signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15796)
17. [HMGA2 and Smads co-regulate SNAIL1 expression during induction of epithelial-to-mesenchymal transition](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15796)
18. [The transforming activity of Ski and SnoN is dependent on their ability to repress the activity of Smad proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15796)
19. [c-Ski inhibits the TGF-beta signaling pathway through stabilization of inactive Smad complexes on Smad-binding elements](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15796)
20. [Potentiation of Smad-mediated transcriptional activation by the RNA-binding protein RBPMS](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15796)
21. [TMEPAI, a transmembrane TGF-beta-inducible protein, sequesters Smad proteins from active participation in TGF-beta signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15796)
22. [ZNF580, a novel C2H2 zinc-finger transcription factor, interacts with the TGF-β signal molecule Smad2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15796)
23. [TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15796)
24. [Nuclear export of Smad2 and Smad3 by RanBP3 facilitates termination of TGF-beta signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15796)
25. [Roles of pathway-specific and inhibitory Smads in activin receptor signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15796)
26. [USP15 is a deubiquitylating enzyme for receptor-activated SMADs](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15796)
27. [The integral inner nuclear membrane protein MAN1 physically interacts with the R-Smad proteins to repress signaling by the transforming growth factor-{beta} superfamily of cytokines](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15796)
28. [Fussel-15, a novel Ski/Sno homolog protein, antagonizes BMP signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15796)
29. [SKI and MEL1 cooperate to inhibit transforming growth factor-beta signal in gastric cancer cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15796)
30. [Functional proteomics mapping of a human signaling pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15796)
31. [A Pin1/mutant p53 axis promotes aggressiveness in breast cancer](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15796)
32. [Identification of PCTA, a TGIF antagonist that promotes PML function in TGF-beta signalling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15796)
33. [TIF1gamma controls erythroid cell fate by regulating transcription elongation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15796)
34. [PPM1A dephosphorylates RanBP3 to enable efficient nuclear export of Smad2 and Smad3](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15796)
35. [Inhibiting Drivers of Non-mutational Drug Tolerance Is a Salvage Strategy for Targeted Melanoma Therapy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15796)
36. [Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15796)
37. [Nodal enhances the activity of FoxO3a and its synergistic interaction with Smads to regulate cyclin G2 transcription in ovarian cancer cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15796)
38. [A Comprehensive Resource of Interacting Protein Regions for Refining Human Transcription Factor Networks](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15796)
39. [Ski-interacting protein interacts with Smad proteins to augment transforming growth factor-beta-dependent transcription](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15796)
40. [Ablation of Smurf2 reveals an inhibition in TGF-β signalling through multiple mono-ubiquitination of Smad3](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15796)
41. [A Mutant-p53/Smad complex opposes p63 to empower TGFbeta-induced metastasis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15796)
42. [Ski co-repressor complexes maintain the basal repressed state of the TGF-beta target gene, SMAD7, via HDAC3 and PRMT5](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15796)
43. [An Id-like molecule, HHM, is a synexpression group-restricted regulator of TGF-beta signalling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15796)
44. [Homeodomain protein DLX4 counteracts key transcriptional control mechanisms of the TGF-β cytostatic program and blocks the antiproliferative effect of TGF-β](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15796)
45. [FAM/USP9x, a deubiquitinating enzyme essential for TGFbeta signaling, controls Smad4 monoubiquitination](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15796)
46. [Identification of novel Smad2 and Smad3 associated proteins in response to TGF-beta1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15796)
47. [Selective targeting of activating and inhibitory Smads by distinct WWP2 ubiquitin ligase isoforms differentially modulates TGFβ signalling and EMT](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15796)
48. [Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein–Protein Interactions in a Pathway Network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15796)
49. [Intercellular variation in signaling through the TGF-β pathway and its relation to cell density and cell cycle phase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15796)
50. [IKKalpha is a critical coregulator of a Smad4-independent TGFbeta-Smad2/3 signaling pathway that controls keratinocyte differentiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15796)