# SMAD family member 1

> mammalian protein found in Homo sapiens

**Wikidata**: [Q699999](https://www.wikidata.org/wiki/Q699999)  
**Source**: https://4ort.xyz/entity/smad-family-member-1-q699999


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q15797)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15797)
5. [Heteromeric and homomeric interactions correlate with signaling activity and functional cooperativity of Smad3 and Smad4/DPC4](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15797)
6. [Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15797)
7. [Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15797)
8. [Regulation of Hex gene expression by a Smads-dependent signaling pathway](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15797&geneProductId=UniProtKB:Q15797)
9. [Regulation of Hex gene expression by a Smads-dependent signaling pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15797)
10. [Mutations in nuclear pore genes NUP93, NUP205 and XPO5 cause steroid-resistant nephrotic syndrome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15797)
11. [Protein associated with SMAD1 (PAWS1/FAM83G) is a substrate for type I bone morphogenetic protein receptors and modulates bone morphogenetic protein signalling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15797)
12. [Nuclear Export of Smads by RanBP3L Regulates Bone Morphogenetic Protein Signaling and Mesenchymal Stem Cell Differentiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15797)
13. [The integral inner nuclear membrane protein MAN1 physically interacts with the R-Smad proteins to repress signaling by the transforming growth factor-{beta} superfamily of cytokines](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15797)
14. [Fussel-15, a novel Ski/Sno homolog protein, antagonizes BMP signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15797)
15. [USP15 is a deubiquitylating enzyme for receptor-activated SMADs](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15797)
16. [Ubiquitin C-terminal hydrolase-L3 regulates Smad1 ubiquitination and osteoblast differentiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15797)
17. [Integrating patterning signals: Wnt/GSK3 regulates the duration of the BMP/Smad1 signal](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15797)
18. [Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein–Protein Interactions in a Pathway Network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15797)
19. [Binding of RhoA by the C2 domain of E3 ligase Smurf1 is essential for Smurf1-regulated RhoA ubiquitination and cell protrusive activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15797)
20. [Structural Basis of Smad1 Activation by Receptor Kinase Phosphorylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15797)
21. [Functional proteomics mapping of a human signaling pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15797)
22. [Nuclear CDKs drive Smad transcriptional activation and turnover in BMP and TGF-beta pathways](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15797)
23. [Charting the molecular links between driver and susceptibility genes in colorectal cancer](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15797)
24. [Coupling of tandem Smad ubiquitination regulatory factor (Smurf) WW domains modulates target specificity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15797)
25. [Unique players in the BMP pathway: small C-terminal domain phosphatases dephosphorylate Smad1 to attenuate BMP signaling.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15797)
26. [SMAD proteins control DROSHA-mediated microRNA maturation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15797)
27. [Control of prostate cell growth: BMP antagonizes androgen mitogenic activity with incorporation of MAPK signals in Smad1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15797)
28. [CHIP controls the sensitivity of transforming growth factor-beta signaling by modulating the basal level of Smad3 through ubiquitin-mediated degradation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15797)
29. [Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15797)
30. [Requirement of the co-repressor homeodomain-interacting protein kinase 2 for ski-mediated inhibition of bone morphogenetic protein-induced transcriptional activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15797)
31. [A census of human transcription factors: function, expression and evolution](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15797)
32. [Serine phosphorylation, chromosomal localization, and transforming growth factor-beta signal transduction by human bsp-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15797)
33. [Signal transduction of bone morphogenetic protein receptors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15797)
34. [Remarkable versatility of Smad proteins in the nucleus of transforming growth factor-beta activated cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15797&geneProductId=UniProtKB:Q15797)
35. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15797&geneProductId=UniProtKB:Q15797)
36. [Holding their own: the noncanonical roles of Smad proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15797)
37. [TGF-beta signal transduction](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15797)
38. [MADR1, a MAD-related protein that functions in BMP2 signaling pathways](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15797)
39. [Rnf165/Ark2C Enhances BMP-Smad Signaling to Mediate Motor Axon Extension](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15797)
40. [Bone morphogenic protein 2 induces Runx2 and osteopontin expression in human aortic valve interstitial cells: role of Smad1 and extracellular signal-regulated kinase 1/2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15797)
41. [MicroRNA-26a regulates pathological and physiological angiogenesis by targeting BMP/SMAD1 signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15797)
42. Ensembl Release 99
43. Identifiers.org
44. UMLS 2023