# SMAD family member 1

> mammalian protein found in Mus musculus

**Wikidata**: [Q14903821](https://www.wikidata.org/wiki/Q14903821)  
**Source**: https://4ort.xyz/entity/smad-family-member-1-q14903821


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P70340)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340)
5. [Structural basis for the cooperative DNA recognition by Smad4 MH1 dimers](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340)
6. [Ecsit is required for Bmp signaling and mesoderm formation during mouse embryogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340)
7. [Isl1Cre reveals a common Bmp pathway in heart and limb development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340)
8. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P70340&geneProductId=UniProtKB:P70340)
9. [Nuclear Export of Smads by RanBP3L Regulates Bone Morphogenetic Protein Signaling and Mesenchymal Stem Cell Differentiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340)
10. [Sertad1 encodes a novel transcriptional co-activator of SMAD1 in mouse embryonic hearts](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340)
11. [SUMO interaction motifs in Sizn1 are required for promyelocytic leukemia protein nuclear body localization and for transcriptional activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340)
12. [Parathyroid hormone-responsive Smad3-related factor, Tmem119, promotes osteoblast differentiation and interacts with the bone morphogenetic protein-Runx2 pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340)
13. [Metalloproteinase/Presenilin1 processing of ephrinB regulates EphB-induced Src phosphorylation and signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340)
14. [Transposon mutagenesis with coat color genotyping identifies an essential role for Skor2 in sonic hedgehog signaling and cerebellum development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340)
15. [B-cell translocation gene 2 (Btg2) regulates vertebral patterning by modulating bone morphogenetic protein/smad signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340)
16. [Menin is required for bone morphogenetic protein 2- and transforming growth factor beta-regulated osteoblastic differentiation through interaction with Smads and Runx2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340)
17. [TAK1 is an essential regulator of BMP signalling in cartilage](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340)
18. [Co-motif discovery identifies an Esrrb-Sox2-DNA ternary complex as a mediator of transcriptional differences between mouse embryonic and epiblast stem cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340)
19. [Bmp signaling regulates myocardial differentiation from cardiac progenitors through a MicroRNA-mediated mechanism](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340)
20. [Smad4-dependent desmoglein-4 expression contributes to hair follicle integrity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340)
21. [Smad proteins function as co-modulators for MEF2 transcriptional regulatory proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340)
22. [Inhibition of microtubule assembly in osteoblasts stimulates bone morphogenetic protein 2 expression and bone formation through transcription factor Gli2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340)
23. [Lack of the bone morphogenetic protein BMP6 induces massive iron overload](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340)
24. [Activation of bone morphogenetic protein/Smad signaling in bronchial epithelial cells during airway inflammation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340)
25. [C-terminal domain (CTD) small phosphatase-like 2 modulates the canonical bone morphogenetic protein (BMP) signaling and mesenchymal differentiation via Smad dephosphorylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340)
26. [Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340)
27. [BMP signaling regulates sympathetic nervous system development through Smad4-dependent and -independent pathways](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340)
28. [Rnf165/Ark2C Enhances BMP-Smad Signaling to Mediate Motor Axon Extension](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340)
29. [The Canonical BMP Signaling Pathway Plays a Crucial Part in Stimulation of Dentin Sialophosphoprotein Expression by BMP-2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340)
30. [Smad expression during kidney development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340)
31. [Regulation of Hex gene expression by a Smads-dependent signaling pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340)
32. [Smad1 and Smad8 function similarly in mammalian central nervous system development.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340)
33. [An Nkx2-5/Bmp2/Smad1 negative feedback loop controls heart progenitor specification and proliferation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340)
34. [Identification of mZnf8, a mouse Krüppel-like transcriptional repressor, as a novel nuclear interaction partner of Smad1.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340)
35. [In vivo convergence of BMP and MAPK signaling pathways: impact of differential Smad1 phosphorylation on development and homeostasis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340)
36. [Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340)
37. [BMP canonical Smad signaling through Smad1 and Smad5 is required for endochondral bone formation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340)
38. [Teashirt 3 is necessary for ureteral smooth muscle differentiation downstream of SHH and BMP4](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340)
39. [Critical function of Prdm14 for the establishment of the germ cell lineage in mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340)
40. [miR-199a, a bone morphogenic protein 2-responsive MicroRNA, regulates chondrogenesis via direct targeting to Smad1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340)
41. [Nanog binds to Smad1 and blocks bone morphogenetic protein-induced differentiation of embryonic stem cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340)
42. [The interferon-inducible p204 protein acts as a transcriptional coactivator of Cbfa1 and enhances osteoblast differentiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340)
43. [Two BMP responsive elements, STAT, and bZIP/HNF4/COUP motifs of the hepcidin promoter are critical for BMP, SMAD1, and HJV responsiveness](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70340)
44. ensembl Release 106