SIX homeobox 3
type: Thing
description: mammalian protein found in Homo sapiens
additional property: PropertyValue
  property ID: P31
  value: protein
additional property: PropertyValue
  property ID: P279
  value: protein
additional property: PropertyValue
  property ID: P352
  value: O95343
additional property: PropertyValue
  property ID: P361
  value: Homeobox-like domain superfamily
additional property: PropertyValue
  property ID: P361
  value: Homeobox protein SIX3
additional property: PropertyValue
  property ID: P361
  value: Homeobox domain, protein family
additional property: PropertyValue
  property ID: P527
  value: Homeobox protein SIX1, N-terminal SD domain
additional property: PropertyValue
  property ID: P527
  value: Homeobox domain
additional property: PropertyValue
  property ID: P637
  value: NP_005404
additional property: PropertyValue
  property ID: P680
  value: RNA polymerase II cis-regulatory region sequence-specific DNA binding
additional property: PropertyValue
  property ID: P680
  value: DNA binding
additional property: PropertyValue
  property ID: P680
  value: sequence-specific DNA binding
additional property: PropertyValue
  property ID: P681
  value: nucleus
additional property: PropertyValue
  property ID: P681
  value: nucleus
additional property: PropertyValue
  property ID: P681
  value: transcription regulator complex
additional property: PropertyValue
  property ID: P682
  value: eye development
additional property: PropertyValue
  property ID: P682
  value: forebrain anterior/posterior pattern specification
additional property: PropertyValue
  property ID: P682
  value: pituitary gland development
additional property: PropertyValue
  property ID: P702
  value: SIX3
additional property: PropertyValue
  property ID: P703
  value: Homo sapiens
additional property: PropertyValue
  property ID: P705
  value: ENSP00000260653
confidence:
  popularity graph score:
    score: 0.002
    score pct: 0
    tier: established
    components:
      sitelinks: 0
      sitelinks norm: 0.0
      unique citations: 17
      unique citations norm: 0.007
      monthly pageviews: 0
      monthly pageviews norm: 0.0
  sitelinks: 0
  unique citations: 17
  monthly pageviews: 0
  yearly pageviews: 0
  tier: established
claims:
  P31:
    value: Q8054
    source count: 1
    confidence: 0.2
    value label: protein
  P279:
    value: Q8054
    source count: 1
    confidence: 0.2
    value label: protein
  P352:
    value: O95343
    source count: 1
    confidence: 0.2
  P361:
    value: Q24769639
    source count: 1
    confidence: 0.2
    value label: Homeobox-like domain superfamily
  P361:
    value: Q24723043
    source count: 1
    confidence: 0.2
    value label: Homeobox protein SIX3
  P361:
    value: Q83138923
    source count: 1
    confidence: 0.2
    value label: Homeobox domain, protein family
  P361:
    value: Q83133623
    source count: 1
    confidence: 0.2
    value label: Homeobox protein SIX1, N-terminal SD domain, protein family
  P527:
    value: Q24721953
    source count: 1
    confidence: 0.2
    value label: Homeobox protein SIX1, N-terminal SD domain
  P527:
    value: Q24769490
    source count: 1
    confidence: 0.2
    value label: Homeobox domain
  P637:
    value: NP_005404
    source count: 1
    confidence: 0.2
  P680:
    value: Q14885806
    source count: 1
    confidence: 0.2
    value label: RNA polymerase II cis-regulatory region sequence-specific DNA binding
  P680:
    value: Q14633858
    source count: 3
    confidence: 0.6
    value label: DNA binding
  P680:
    value: Q14818107
    source count: 1
    confidence: 0.2
    value label: sequence-specific DNA binding
  P680:
    value: Q14817979
    source count: 2
    confidence: 0.4
    value label: DNA-binding transcription factor activity
  P680:
    value: Q14860440
    source count: 2
    confidence: 0.4
    value label: transcription coactivator activity
  P681:
    value: Q40260
    source count: 2
    confidence: 0.4
    value label: nucleus
  P681:
    value: Q40260
    source count: 3
    confidence: 0.6
    value label: nucleus
  P681:
    value: Q14818102
    source count: 1
    confidence: 0.2
    value label: transcription regulator complex
  P682:
    value: Q5422650
    source count: 3
    confidence: 0.6
    value label: eye development
  P682:
    value: Q14916200
    source count: 1
    confidence: 0.2
    value label: forebrain anterior/posterior pattern specification
  P682:
    value: Q14886419
    source count: 2
    confidence: 0.4
    value label: pituitary gland development
  P682:
    value: Q14633883
    source count: 1
    confidence: 0.2
    value label: regulation of transcription, DNA-templated
  P682:
    value: Q14633915
    source count: 2
    confidence: 0.4
    value label: negative regulation of neuron differentiation
  P702:
    value: Q18031510
    source count: 1
    confidence: 0.2
    value label: SIX3

value: Q15978631
source count: 1
confidence: 0.2
value label: Homo sapiens

value: ENSP00000260653
source count: 1
confidence: 0.2

source: GOA
stated in qid: Q28018111
retrieved: 2019-04-08

source: GOA
stated in qid: Q28018111
retrieved: 2018-03-27

source: The homeotic protein Six3 is a coactivator of the nuclear receptor NOR-1 and a corepressor of the fusion protein EWS/NOR-1 in human extraskeletal myxoid chondrosarcomas
stated in qid: Q24293141
retrieved: 2019-04-08

source: Six3 and Six6 activity is modulated by members of the groucho family
stated in qid: Q24319179
retrieved: 2019-04-08

source: Direct interaction of geminin and Six3 in eye development
stated in qid: Q24310108
retrieved: 2019-04-08

source: A census of human transcription factors: function, expression and evolution
stated in qid: Q29622841
retrieved: 2018-11-07

source: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
stated in qid: Q34211397
retrieved: 2019-04-08

source: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
stated in qid: Q34211397
retrieved: 2018-09-10

source: A census of human transcription factors: function, expression and evolution
stated in qid: Q29622841
retrieved: 2019-04-08

source: Mutations in the human SIX3 gene in holoprosencephaly are loss of function
stated in qid: Q24312256
retrieved: 2018-03-27

source: Mutations in the human SIX3 gene in holoprosencephaly are loss of function
stated in qid: Q24312256
retrieved: 2019-04-08

source: Mutations in the homeodomain of the human SIX3 gene cause holoprosencephaly
stated in qid: Q22009990
retrieved: 2018-03-27

source: Mutations in the homeodomain of the human SIX3 gene cause holoprosencephaly
stated in qid: Q22009990
retrieved: 2019-04-08

source: InterPro Release 71.0
stated in qid: Q58943792

source: UniProt
stated in qid: Q905695
retrieved: 2019-11-13

source: Q20641742
stated in qid: Q20641742
retrieved: 2020-05-30

source: Ensembl Release 99
stated in qid: Q83867711

wikidata id: Q21135600
domain: protein
level: standard
html url: https://4ort.xyz/entity/six-homeobox-3
markdown url: https://4ort.xyz/entity/six-homeobox-3.md
facts url summary: https://4ort.xyz/entity/six-homeobox-3/facts.json
facts url standard: https://4ort.xyz/entity/six-homeobox-3/facts.json
facts url full: https://4ort.xyz/entity/six-homeobox-3/facts.json
data source: Wikidata (CC0 / public domain)
license: https://creativecommons.org/publicdomain/zero/1.0/
api version: v1
served at: 2026-08-31T13:56:18.996175Z
entity updated at: 2026-05-03T18:28:36.114423+00:00Z
entity created at: 2026-05-03T13:47:25.717321+00:00Z