# Sirtuin 6

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21120885](https://www.wikidata.org/wiki/Q21120885)  
**Source**: https://4ort.xyz/entity/sirtuin-6-q21120885


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q8N6T7)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N6T7)
5. [Human SIRT6 promotes DNA end resection through CtIP deacetylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N6T7)
6. [The histone deacetylase SIRT6 is a tumor suppressor that controls cancer metabolism](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N6T7)
7. [SIRT6 links histone H3 lysine 9 deacetylation to NF-kappaB-dependent gene expression and organismal life span](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N6T7)
8. [Sirtuin functions in health and disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N6T7)
9. [SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N6T7)
10. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N6T7)
11. [Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N6T7)
12. [Depletion of SIRT6 causes cellular senescence, DNA damage, and telomere dysfunction in human chondrocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N6T7)
13. [SIRT6 protects human endothelial cells from DNA damage, telomere dysfunction, and senescence](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N6T7)
14. [Cold-Inducible SIRT6 Regulates Thermogenesis of Brown and Beige Fat.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N6T7)
15. Ensembl Release 99