# Sirtuin 5

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21125222](https://www.wikidata.org/wiki/Q21125222)  
**Source**: https://4ort.xyz/entity/sirtuin-5


## References

1. UniProt
2. [BioGRID](https://thebiogrid.org/news/227)
3. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q9NXA8)
4. Q20641742
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NXA8)
6. [Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NXA8)
7. [Sirtuin functions in health and disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NXA8)
8. [Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NXA8)
9. [The first identification of lysine malonylation substrates and its regulatory enzyme](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NXA8)
10. [Lysine glutarylation is a protein posttranslational modification regulated by SIRT5](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NXA8)
11. [SHMT2 Desuccinylation by SIRT5 Drives Cancer Cell Proliferation.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NXA8)
12. [SIRT5 desuccinylates and activates SOD1 to eliminate ROS](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NXA8)
13. [Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NXA8&geneProductId=UniProtKB:Q9NXA8)
14. [Substrates and regulation mechanisms for the human mitochondrial sirtuins Sirt3 and Sirt5](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NXA8)
15. [SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NXA8)
16. [Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NXA8)
17. Ensembl Release 99