# Sirtuin 2

> mammalian protein found in Mus musculus

**Wikidata**: [Q21981230](https://www.wikidata.org/wiki/Q21981230)  
**Source**: https://4ort.xyz/entity/sirtuin-2


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q8VDQ8)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDQ8)
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8VDQ8&geneProductId=UniProtKB:Q8VDQ8)
6. [SIRT2 deacetylates FOXO3a in response to oxidative stress and caloric restriction](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8VDQ8&geneProductId=UniProtKB:Q8VDQ8)
7. [A role for SIRT2-dependent histone H3K18 deacetylation in bacterial infection](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDQ8)
8. [SIRT2 suppresses adipocyte differentiation by deacetylating FOXO1 and enhancing FOXO1's repressive interaction with PPARgamma](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDQ8)
9. [SIRT2 deacetylates FOXO3a in response to oxidative stress and caloric restriction](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDQ8)
10. [SIRT2 regulates adipocyte differentiation through FoxO1 acetylation/deacetylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDQ8)
11. [SIRT2 maintains genome integrity and suppresses tumorigenesis through regulating APC/C activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDQ8)
12. [Sirt2 functions in spindle organization and chromosome alignment in mouse oocyte meiosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDQ8)
13. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDQ8)
14. [SIRT2 regulates adipocyte differentiation through FoxO1 acetylation/deacetylation](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8VDQ8&geneProductId=UniProtKB:Q8VDQ8)
15. [SIRT2 suppresses adipocyte differentiation by deacetylating FOXO1 and enhancing FOXO1's repressive interaction with PPARgamma](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8VDQ8&geneProductId=UniProtKB:Q8VDQ8)
16. [Proteolipid protein is required for transport of sirtuin 2 into CNS myelin](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8VDQ8&geneProductId=UniProtKB:Q8VDQ8)
17. [Sirt2 functions in spindle organization and chromosome alignment in mouse oocyte meiosis](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8VDQ8&geneProductId=UniProtKB:Q8VDQ8)
18. [Cloning and characterization of two mouse genes with homology to the yeast Sir2 gene](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8VDQ8&geneProductId=UniProtKB:Q8VDQ8)
19. [Microtubule deacetylases, SirT2 and HDAC6, in the nervous system](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDQ8)
20. [Nutritional stress exacerbates hepatic steatosis induced by deletion of the histidine nucleotide-binding (Hint2) mitochondrial protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDQ8)
21. [Microtubule deacetylases, SirT2 and HDAC6, in the nervous system](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8VDQ8&geneProductId=UniProtKB:Q8VDQ8)
22. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8VDQ8&geneProductId=UniProtKB:Q8VDQ8)
23. [Cloning and characterization of two mouse genes with homology to the yeast Sir2 gene](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDQ8)
24. [Proteolipid protein is required for transport of sirtuin 2 into CNS myelin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDQ8)
25. [Microtubule-driven spatial arrangement of mitochondria promotes activation of the NLRP3 inflammasome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDQ8)
26. [Regulation of adipogenesis by cytoskeleton remodelling is facilitated by acetyltransferase MEC-17-dependent acetylation of α-tubulin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDQ8)
27. [The ATAC acetyl transferase complex controls mitotic progression by targeting non-histone substrates.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDQ8)
28. [SIRT2 regulates tumour hypoxia response by promoting HIF-1α hydroxylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDQ8)
29. [Sir-two-homolog 2 (Sirt2) modulates peripheral myelination through polarity protein Par-3/atypical protein kinase C (aPKC) signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDQ8)
30. [SIRT2 regulates tumour hypoxia response by promoting HIF-1α hydroxylation](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8VDQ8&geneProductId=UniProtKB:Q8VDQ8)
31. [A role for SIRT2-dependent histone H3K18 deacetylation in bacterial infection](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8VDQ8&geneProductId=UniProtKB:Q8VDQ8)
32. ensembl Release 106