# Sirtuin 2

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21108304](https://www.wikidata.org/wiki/Q21108304)  
**Source**: https://4ort.xyz/entity/sirtuin-2-q21108304


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q8IXJ6)
3. Q20641742
4. [The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IXJ6)
5. [Human histone deacetylase SIRT2 interacts with the homeobox transcription factor HOXA10](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IXJ6&geneProductId=UniProtKB:Q8IXJ6)
6. [Sir2 regulates skeletal muscle differentiation as a potential sensor of the redox state](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IXJ6&geneProductId=UniProtKB:Q8IXJ6)
7. [Cytosolic FoxO1 is essential for the induction of autophagy and tumour suppressor activity](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IXJ6&geneProductId=UniProtKB:Q8IXJ6)
8. [FOXO4 is acetylated upon peroxide stress and deacetylated by the longevity protein hSir2(SIRT1)](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IXJ6&geneProductId=UniProtKB:Q8IXJ6)
9. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IXJ6&geneProductId=UniProtKB:Q8IXJ6)
10. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IXJ6)
11. [A role for SIRT2-dependent histone H3K18 deacetylation in bacterial infection](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IXJ6)
12. [Cytosolic FoxO1 is essential for the induction of autophagy and tumour suppressor activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IXJ6)
13. [Multiple histone deacetylases and the CREB-binding protein regulate pre-mRNA 3'-end processing](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IXJ6)
14. [Structure of the histone deacetylase SIRT2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IXJ6)
15. [Sir-two-homolog 2 (Sirt2) modulates peripheral myelination through polarity protein Par-3/atypical protein kinase C (aPKC) signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IXJ6)
16. [SIRT2 regulates tumour hypoxia response by promoting HIF-1α hydroxylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IXJ6)
17. [Acetylation Stabilizes ATP-Citrate Lyase to Promote Lipid Biosynthesis and Tumor Growth](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IXJ6)
18. [Interphase nucleo-cytoplasmic shuttling and localization of SIRT2 during mitosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IXJ6)
19. [Acetylation of Sirt2 by p300 attenuates its deacetylase activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IXJ6)
20. [Oncogenic microtubule hyperacetylation through BEX4-mediated sirtuin 2 inhibition](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IXJ6)
21. [Regulation of G6PD acetylation by KAT9/SIRT2 modulates NADPH homeostasis and cell survival during oxidative stress](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IXJ6)
22. [Role for human SIRT2 NAD-dependent deacetylase activity in control of mitotic exit in the cell cycle](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IXJ6)
23. [SIRT2 regulates NF-κB dependent gene expression through deacetylation of p65 Lys310](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IXJ6)
24. [Sir2 regulates skeletal muscle differentiation as a potential sensor of the redox state](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IXJ6)
25. [SIRT2 induces the checkpoint kinase BubR1 to increase lifespan](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IXJ6)
26. [Furry promotes acetylation of microtubules in the mitotic spindle by inhibition of SIRT2 tubulin deacetylase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IXJ6)
27. [SirT2 is a histone deacetylase with preference for histone H4 Lys 16 during mitosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IXJ6)
28. [Mitotic regulation of SIRT2 by cyclin-dependent kinase 1-dependent phosphorylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IXJ6)
29. [Structure of the histone deacetylase SIRT2](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IXJ6&geneProductId=UniProtKB:Q8IXJ6)
30. [Sirtuin functions in health and disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IXJ6)
31. [Constitutive nuclear localization of an alternatively spliced sirtuin-2 isoform](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IXJ6&geneProductId=UniProtKB:Q8IXJ6)
32. [Role for human SIRT2 NAD-dependent deacetylase activity in control of mitotic exit in the cell cycle](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IXJ6&geneProductId=UniProtKB:Q8IXJ6)
33. [FOXO4 is acetylated upon peroxide stress and deacetylated by the longevity protein hSir2(SIRT1)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IXJ6)
34. [Human histone deacetylase SIRT2 interacts with the homeobox transcription factor HOXA10](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IXJ6)
35. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IXJ6)
36. [Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IXJ6)
37. [Deacetylation of FOXO3 by SIRT1 or SIRT2 leads to Skp2-mediated FOXO3 ubiquitination and degradation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IXJ6)
38. [Quantitative Proteomic Analysis of Human Substantia Nigra in Alzheimer’s Disease, Huntington’s Disease and Multiple Sclerosis](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IXJ6&geneProductId=UniProtKB:Q8IXJ6)
39. [Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IXJ6)
40. [Quantitative Proteomic Analysis of Human Substantia Nigra in Alzheimer’s Disease, Huntington’s Disease and Multiple Sclerosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IXJ6)
41. Ensembl Release 99
42. UMLS 2023