# sirtuin 1

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21113719](https://www.wikidata.org/wiki/Q21113719)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/Sirtuin_1)  
**Source**: https://4ort.xyz/entity/sirtuin-1


## References

1. UniProt
2. IUPHAR/BPS Guide to PHARMACOLOGY
3. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q96EB6)
4. Q20641742
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6)
6. [Human Sir2-related protein SIRT1 associates with the bHLH repressors HES1 and HEY2 and is involved in HES1- and HEY2-mediated transcriptional repression](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6)
7. [Regulation of WRN protein cellular localization and enzymatic activities by SIRT1-mediated deacetylation](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6)
8. [A high-confidence interaction map identifies SIRT1 as a mediator of acetylation of USP22 and the SAGA coactivator complex](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6)
9. [Regulation of unfolded protein response modulator XBP1s by acetylation and deacetylation](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6)
10. [SIRT1 Regulates UV-Induced DNA Repair through Deacetylating XPA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6)
11. [MicroRNA-34a induces endothelial progenitor cell senescence and impedes its angiogenesis via suppressing silent information regulator 1](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6)
12. [SIRT1 deacetylates APE1 and regulates cellular base excision repair](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6)
13. [Sirt1 deacetylates c-Myc and promotes c-Myc/Max association](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6)
14. [Angiogenesis Inhibitor Vasohibin-1 Enhances Stress Resistance of Endothelial Cells via Induction of SOD2 and SIRT1](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6)
15. [JNK1 phosphorylates SIRT1 and promotes its enzymatic activity](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6)
16. [Dynamic distribution of linker histone H1.5 in cellular differentiation](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6)
17. [Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6)
18. [CCAR2 negatively regulates nuclear receptor LXRα by competing with SIRT1 deacetylase](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6)
19. [DBC1 is a negative regulator of SIRT1](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6)
20. [Multiple histone deacetylases and the CREB-binding protein regulate pre-mRNA 3'-end processing](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6)
21. [MST1 promotes apoptosis through regulating Sirt1-dependent p53 deacetylation](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6)
22. [HDAC3 Is Negatively Regulated by the Nuclear Protein DBC1](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6)
23. [Identification and characterization of proteins interacting with SIRT1 and SIRT3: implications in the anti-aging and metabolic effects of sirtuins](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6)
24. [Carboxy-terminal phosphorylation of SIRT1 by protein kinase CK2](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6)
25. [Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6)
26. [Enzymes in the NAD+ salvage pathway regulate SIRT1 activity at target gene promoters](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6)
27. [Active regulator of SIRT1 cooperates with SIRT1 and facilitates suppression of p53 activity](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6)
28. [Transcriptional corepressor SMILE recruits SIRT1 to inhibit nuclear receptor estrogen receptor-related receptor gamma transactivation](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6)
29. [Brown remodeling of white adipose tissue by SirT1-dependent deacetylation of Pparγ](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6)
30. [Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6)
31. [The deacetylase SIRT1 promotes membrane localization and activation of Akt and PDK1 during tumorigenesis and cardiac hypertrophy](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6)
32. [SIRT1 regulates the function of the Nijmegen breakage syndrome protein](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6)
33. [SIRT1 activates MAO-A in the brain to mediate anxiety and exploratory drive](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6)
34. [Novel repressor regulates insulin sensitivity through interaction with Foxo1](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6)
35. [Phosphoinositide 3-kinase as a novel functional target for the regulation of the insulin signaling pathway by SIRT1](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6)
36. [SIRT2 regulates NF-κB dependent gene expression through deacetylation of p65 Lys310](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6)
37. [FOXO4 is acetylated upon peroxide stress and deacetylated by the longevity protein hSir2(SIRT1)](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6)
38. [CK2 is the regulator of SIRT1 substrate-binding affinity, deacetylase activity and cellular response to DNA-damage](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6)
39. [Global landscape of HIV-human protein complexes](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6)
40. [Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6)
41. [SIRT1 regulates Dishevelled proteins and promotes transient and constitutive Wnt signaling](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6)
42. [hSirT1-dependent regulation of the PCAF-E2F1-p73 apoptotic pathway in response to DNA damage](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6)
43. [The evolutionarily conserved longevity determinants HCF-1 and SIR-2.1/SIRT1 collaborate to regulate DAF-16/FOXO](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6)
44. [Hyaluronan-mediated CD44 interaction with p300 and SIRT1 regulates beta-catenin signaling and NFkappaB-specific transcription activity leading to MDR1 and Bcl-xL gene expression and chemoresistance in breast tumor cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6)
45. [p53 deacetylation by SIRT1 decreases during protein kinase CKII downregulation-mediated cellular senescence](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6)
46. [Suppression of FOXO1 activity by FHL2 through SIRT1-mediated deacetylation](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6)
47. [SIRT1 deacetylates and positively regulates the nuclear receptor LXR](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6)
48. [Oxidative damage targets complexes containing DNA methyltransferases, SIRT1, and polycomb members to promoter CpG Islands](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6)
49. [SIRT1 deacetylates and inhibits SREBP-1C activity in regulation of hepatic lipid metabolism](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6)
50. [SIRT1 promotes DNA repair activity and deacetylation of Ku70](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EB6&geneProductId=UniProtKB:Q96EB6)