# Sirtuin 1

> mammalian protein found in Mus musculus

**Wikidata**: [Q21498104](https://www.wikidata.org/wiki/Q21498104)  
**Source**: https://4ort.xyz/entity/sirtuin-1-q21498104


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q923E4)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q923E4&geneProductId=UniProtKB:Q923E4)
5. [Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q923E4&geneProductId=UniProtKB:Q923E4)
6. [Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4)
7. [Circadian clock feedback cycle through NAMPT-mediated NAD+ biosynthesis](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q923E4&geneProductId=UniProtKB:Q923E4)
8. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4)
9. [Reversible acetylation of the chromatin remodelling complex NoRC is required for non-coding RNA-dependent silencing](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4)
10. [GAPDH mediates nitrosylation of nuclear proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4)
11. [Angiogenesis Inhibitor Vasohibin-1 Enhances Stress Resistance of Endothelial Cells via Induction of SOD2 and SIRT1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4)
12. [DYRK1A and DYRK3 promote cell survival through phosphorylation and activation of SIRT1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4)
13. [SIRT2 deacetylates FOXO3a in response to oxidative stress and caloric restriction](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4)
14. [Metastasis-associated protein 1 is an integral component of the circadian molecular machinery](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4)
15. [SIRT1 regulates circadian clock gene expression through PER2 deacetylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4)
16. [Circadian clock feedback cycle through NAMPT-mediated NAD+ biosynthesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4)
17. [SIRT1 regulates the histone methyl-transferase SUV39H1 during heterochromatin formation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4)
18. [BCL6 controls neurogenesis through Sirt1-dependent epigenetic repression of selective Notch targets](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4)
19. [Interactions between E2F1 and SirT1 regulate apoptotic response to DNA damage](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4)
20. [SIRT1 functionally interacts with the metabolic regulator and transcriptional coactivator PGC-1{alpha}](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4)
21. [A nutrient‐sensitive interaction between Sirt1 and HNF‐1α regulates Crp expression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4)
22. [The NAD+-dependent deacetylase SIRT1 modulates CLOCK-mediated chromatin remodeling and circadian control](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4)
23. [Deacetylation of the retinoblastoma tumour suppressor protein by SIRT1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4)
24. [Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4)
25. [Transcriptional corepressor SHP recruits SIRT1 histone deacetylase to inhibit LRH-1 transactivation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4)
26. [SIRT1 inhibits transforming growth factor beta-induced apoptosis in glomerular mesangial cells via Smad7 deacetylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4)
27. [Histone deacetylase SIRT1 modulates neuronal differentiation by its nuclear translocation.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4)
28. [hSIR2SIRT1 Functions as an NAD-Dependent p53 Deacetylase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4)
29. [Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4)
30. [Brown remodeling of white adipose tissue by SirT1-dependent deacetylation of Pparγ](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4)
31. [SIRT1 deacetylates and inhibits SREBP-1C activity in regulation of hepatic lipid metabolism](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4)
32. [The direct involvement of SirT1 in insulin-induced insulin receptor substrate-2 tyrosine phosphorylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4)
33. [CK2 is the regulator of SIRT1 substrate-binding affinity, deacetylase activity and cellular response to DNA-damage](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4)
34. [Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4)
35. [SIRT1 activates MAO-A in the brain to mediate anxiety and exploratory drive](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4)
36. [Negative Control of p53 by Sir2α Promotes Cell Survival under Stress](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q923E4&geneProductId=UniProtKB:Q923E4)
37. [Acetylation of TAF(I)68, a subunit of TIF-IB/SL1, activates RNA polymerase I transcription](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4)
38. [Upregulated sirtuin 1 by miRNA-34a is required for smooth muscle cell differentiation from pluripotent stem cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q923E4&geneProductId=UniProtKB:Q923E4)
39. [Upregulated sirtuin 1 by miRNA-34a is required for smooth muscle cell differentiation from pluripotent stem cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4)
40. [SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q923E4&geneProductId=UniProtKB:Q923E4)
41. [Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q923E4&geneProductId=UniProtKB:Q923E4)
42. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q923E4&geneProductId=UniProtKB:Q923E4)
43. [Negative Control of p53 by Sir2α Promotes Cell Survival under Stress](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4)
44. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4)
45. [SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4)
46. [Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4)
47. [Nucleocytoplasmic shuttling of the NAD+-dependent histone deacetylase SIRT1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4)
48. [SIRT1 promotes cell survival under stress by deacetylation-dependent deactivation of poly(ADP-ribose) polymerase 1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4)
49. [The NAD biosynthesis pathway mediated by nicotinamide phosphoribosyltransferase regulates Sir2 activity in mammalian cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4)
50. [The mammalian SIR2alpha protein has a role in embryogenesis and gametogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q923E4)