# Sirtuin 1 Dmel_CG5216

> protein found in Drosophila melanogaster

**Wikidata**: [Q29812238](https://www.wikidata.org/wiki/Q29812238)  
**Source**: https://4ort.xyz/entity/sirtuin-1-dmel-cg5216


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q9VK34)
3. Q20641742
4. [Global and specific responses of the histone acetylome to systematic perturbation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK34)
5. [dSIR2 and dHDAC6: two novel, inhibitor-resistant deacetylases in Drosophila melanogaster](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK34)
6. [Individual histone deacetylases in Drosophila modulate transcription of distinct genes.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK34)
7. [Heterochromatin-mediated gene silencing is not affected by Drosophila CBP activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK34)
8. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK34)
9. [A Drosophila homologue of Sir2 modifies position-effect variegation but does not affect life span](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VK34&geneProductId=UniProtKB:Q9VK34)
10. [Drosophila Sir2 is required for heterochromatic silencing and by euchromatic Hairy/E(Spl) bHLH repressors in segmentation and sex determination](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VK34&geneProductId=UniProtKB:Q9VK34)
11. [Conserved enzymatic production and biological effect of O-acetyl-ADP-ribose by silent information regulator 2-like NAD+-dependent deacetylases](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VK34&geneProductId=UniProtKB:Q9VK34)
12. [SIR2 is required for polycomb silencing and is associated with an E(Z) histone methyltransferase complex](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VK34&geneProductId=UniProtKB:Q9VK34)
13. [Sir2 Acts through Hepatocyte Nuclear Factor 4 to maintain insulin Signaling and Metabolic Homeostasis in Drosophila](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK34)
14. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VK34&geneProductId=UniProtKB:Q9VK34)
15. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VK34&geneProductId=UniProtKB:Q9VK34)
16. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK34)
17. [A Drosophila homologue of Sir2 modifies position-effect variegation but does not affect life span](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK34)
18. [SIR2 is required for polycomb silencing and is associated with an E(Z) histone methyltransferase complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK34)
19. [Conserved enzymatic production and biological effect of O-acetyl-ADP-ribose by silent information regulator 2-like NAD+-dependent deacetylases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK34)
20. [Drosophila Sir2 is required for heterochromatic silencing and by euchromatic Hairy/E(Spl) bHLH repressors in segmentation and sex determination](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK34)
21. [Drosophila poly(ADP-ribose) glycohydrolase mediates chromatin structure and SIR2-dependent silencing](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VK34&geneProductId=UniProtKB:Q9VK34)
22. [Drosophila poly(ADP-ribose) glycohydrolase mediates chromatin structure and SIR2-dependent silencing](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK34)
23. [Individual histone deacetylases in Drosophila modulate transcription of distinct genes.](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VK34&geneProductId=UniProtKB:Q9VK34)
24. [Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK34)
25. [Involvement of Drosophila Sir2-like genes in the regulation of life span](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK34)
26. [Sir2 mediates apoptosis through JNK-dependent pathways in Drosophila](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK34)
27. [Ethanol-regulated genes that contribute to ethanol sensitivity and rapid tolerance in Drosophila](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK34)
28. [Sir2/Sirt1 Links Acute Inebriation to Presynaptic Changes and the Development of Alcohol Tolerance, Preference, and Reward](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK34)
29. [Minibrain/Dyrk1a regulates food intake through the Sir2-FOXO-sNPF/NPY pathway in Drosophila and mammals](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK34)
30. ensembl Release 106