# sirolimus

> Immunosuppressive medicine used to prevent rejection of transplanted organs

**Wikidata**: [Q32089](https://www.wikidata.org/wiki/Q32089)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/Sirolimus)  
**Source**: https://4ort.xyz/entity/sirolimus


## References

1. IUPHAR/BPS Guide to PHARMACOLOGY
2. Sirolimus. DrugBank. 2015
3. Global Substance Registration System
4. [CAS Common Chemistry](https://commonchemistry.cas.org/detail?cas_rn=53123-88-9)
5. (1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28E,30S,32S,35R)-1,18-dihydroxy-12-[(2R)-1-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]propan-2-yl]-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo[30.3.1.0⁴,⁹]hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentone. ECHA Substance Infocard database
6. Rapamycin. PubChem
7. Gene Ontology release 2019-11-16
8. [Rapamycin can add years to your life, or none at all – it’s a lottery | New Scientist](https://www.newscientist.com/article/2516893-rapamycin-can-add-years-to-your-life-or-none-at-all-its-a-lottery)
9. SIROLIMUS. ChEMBL
10. sirolimus. IUPHAR/BPS Guide to PHARMACOLOGY
11. [Source](https://www.guidetopharmacology.org/coronavirus.jsp)
12. Freebase Data Dumps. 2013
13. SIROLIMUS. NDF-RT
14. Sirolimus. ChemSpider
15. Sirolimus. ChEMBL
16. ChEBI release 2021-03-01
17. Incorporation of acetate, propionate, and methionine into rapamycin by Streptomyces hygroscopicus
18. Rapamycin (AY-22,989), a new antifungal antibiotic. II. Fermentation, isolation and characterization.
19. Secretion of FK506/FK520 and rapamycin by Streptomyces inhibits the growth of competing Saccharomyces cerevisiae and Cryptococcus neoformans
20. Cytochrome p450 complement (CYPome) of the avermectin-producer Streptomyces avermitilis and comparison to that of Streptomyces coelicolor A3(2).
21. Organization of the biosynthetic gene cluster for the macrolide concanamycin A in Streptomyces neyagawaensis ATCC 27449.
22. A combined approach of classical mutagenesis and rational metabolic engineering improves rapamycin biosynthesis and provides insights into methylmalonyl-CoA precursor supply pathway in Streptomyces hygroscopicus ATCC 29253
23. Waking up Streptomyces secondary metabolism by constitutive expression of activators or genetic disruption of repressors
24. Effects of dissolved oxygen level on rapamycin production by pellet-form of Streptomyces hygroscopicus
25. Studies on process optimization methods for rapamycin production using Streptomyces hygroscopicus ATCC 29253.
26. Production of rapamycin in Streptomyces hygroscopicus from glycerol-based media optimized by systemic methodology
27. Draft Genome Sequence of Streptomyces iranensis.
28. Discovery of actinoplanic acid pathway in reveals a genetically conserved synergism with rapamycin
29. Carbon source nutrition of rapamycin biosynthesis in Streptomyces hygroscopicus
30. Organisation of the biosynthetic gene cluster for rapamycin in Streptomyces hygroscopicus: analysis of genes flanking the polyketide synthase
31. An amplifiable and deletable locus of Streptomyces ambofaciens RP181110 contains a very large gene homologous to polyketide synthase genes
32. The Pipecolate‐Incorporating Enzyme for the Biosynthesis of the Immunosuppressant Rapamycin — Nucleotide Sequence Analysis, Disruption and Heterologous Expression of Rap P from Streptomyces Hygroscopicus
33. Effect of nitrogen source on biosynthesis of rapamycin by Streptomyces hygroscopicus
34. A second type-I PKS gene cluster isolated from Streptomyces hygroscopicus ATCC 29253, a rapamycin-producing strain
35. Isolation and Structure of Homotemsirolimuses A, B, and C
36. Leucinostatins from Ophiocordyceps spp. and Purpureocillium spp. Demonstrate Selective Antiproliferative Effects in Cells Representing the Luminal Androgen Receptor Subtype of Triple Negative Breast Cancer
37. A reference set of clinically relevant adverse drug-drug interactions
38. SIROLIMUS. Hazardous Substances Data Bank. 2019
39. Drug Indications Extracted from FAERS
40. Recommended INN: List 34
41. Recommended INN: List 77
42. NDF-RT
43. Medical Subject Headings
44. ChEBI
45. Mapping file of InChIStrings, InChIKeys and DTXSIDs for the EPA CompTox Dashboard
46. [FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.](https://nctr-crs.fda.gov/fdalabel/ui/spl-summaries/criteria/343802)
47. RxNorm
48. [Source](https://www.whocc.no/atc_ddd_index/?code=L04AA10)
49. [OpenAlex](https://docs.openalex.org/download-snapshot/snapshot-data-format)
50. UniChem