# Sine oculis-related homeobox 3

> mammalian protein found in Mus musculus

**Wikidata**: [Q21496861](https://www.wikidata.org/wiki/Q21496861)  
**Source**: https://4ort.xyz/entity/sine-oculis-related-homeobox-3


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q62233)
3. Q20641742
4. [Six3 activation of Pax6 expression is essential for mammalian lens induction and specification](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62233)
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62233)
6. [Six3-mediated auto repression and eye development requires its interaction with members of the Groucho-related family of co-repressors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62233)
7. [Identification and expression of six family genes in mouse retina](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62233)
8. [Repression of Six3 by a corepressor regulates rhodopsin expression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62233)
9. [Six3 activation of Pax6 expression is essential for mammalian lens induction and specification](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62233&geneProductId=UniProtKB:Q62233)
10. [EYA4, deleted in a case with middle interhemispheric variant of holoprosencephaly, interacts with SIX3 both physically and functionally](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62233)
11. [Pax6-dependence of Six3, Eya1 and Dach1 expression during lens and nasal placode induction](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62233)
12. [Six3 repression of Wnt signaling in the anterior neuroectoderm is essential for vertebrate forebrain development](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62233&geneProductId=UniProtKB:Q62233)
13. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62233&geneProductId=UniProtKB:Q62233)
14. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62233)
15. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62233&geneProductId=UniProtKB:Q62233)
16. [Six3 repression of Wnt signaling in the anterior neuroectoderm is essential for vertebrate forebrain development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62233)
17. [Pax6-dependence of Six3, Eya1 and Dach1 expression during lens and nasal placode induction](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62233&geneProductId=UniProtKB:Q62233)
18. [Identification and expression of six family genes in mouse retina](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62233&geneProductId=UniProtKB:Q62233)
19. [Six3-mediated auto repression and eye development requires its interaction with members of the Groucho-related family of co-repressors](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62233&geneProductId=UniProtKB:Q62233)
20. [Six3 inactivation causes progressive caudalization and aberrant patterning of the mammalian diencephalon](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62233)
21. [Genetic interaction between the homeobox transcription factors HESX1 and SIX3 is required for normal pituitary development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62233)
22. [Six3 controls the neural progenitor status in the murine CNS](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62233)
23. [Six3 inactivation reveals its essential role for the formation and patterning of the vertebrate eye](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62233)
24. [Mutually regulated expression of Pax6 and Six3 and its implications for the Pax6 haploinsufficient lens phenotype](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62233)
25. [Six3 is required for ependymal cell maturation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62233)
26. [Six3 promotes the formation of ectopic optic vesicle-like structures in mouse embryos](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62233)
27. [Haploinsufficiency of Six3 fails to activate Sonic hedgehog expression in the ventral forebrain and causes holoprosencephaly](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62233)
28. [Neuroretina specification in mouse embryos requires Six3-mediated suppression of Wnt8b in the anterior neural plate](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62233)
29. [Antagonistic action of Six3 and Prox1 at the gamma-crystallin promoter](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62233)
30. [Development, Maturation, and Necessity of Transcription Factors in the Mouse Suprachiasmatic Nucleus](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62233)
31. [Antagonistic action of Six3 and Prox1 at the gamma-crystallin promoter](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62233&geneProductId=UniProtKB:Q62233)
32. ensembl Release 106