# Sine oculis-related homeobox 1

> mammalian protein found in Mus musculus

**Wikidata**: [Q21981883](https://www.wikidata.org/wiki/Q21981883)  
**Source**: https://4ort.xyz/entity/sine-oculis-related-homeobox-1


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q62231)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62231)
5. [Eya1 and Eya2 proteins are required for hypaxial somitic myogenesis in the mouse embryo](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62231)
6. [Expression of myogenin during embryogenesis is controlled by Six/sine oculis homeoproteins through a conserved MEF3 binding site](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62231)
7. [Slc12a2 is a direct target of two closely related homeobox proteins, Six1 and Six4](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62231)
8. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62231&geneProductId=UniProtKB:Q62231)
9. [Ski regulates muscle terminal differentiation by transcriptional activation of Myog in a complex with Six1 and Eya3](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62231)
10. [Molecular interaction and synergistic activation of a promoter by Six, Eya, and Dach proteins mediated through CREB binding protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62231)
11. [EYA1 and SIX1 drive the neuronal developmental program in cooperation with the SWI/SNF chromatin-remodeling complex and SOX2 in the mammalian inner ear](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62231)
12. [SIX1 acts synergistically with TBX18 in mediating ureteral smooth muscle formation.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62231)
13. [SIX1 mutations cause branchio-oto-renal syndrome by disruption of EYA1-SIX1-DNA complexes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62231)
14. [Molecular effects of Eya1 domain mutations causing organ defects in BOR syndrome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62231)
15. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62231)
16. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62231&geneProductId=UniProtKB:Q62231)
17. [Eya protein phosphatase activity regulates Six1-Dach-Eya transcriptional effects in mammalian organogenesis](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62231&geneProductId=UniProtKB:Q62231)
18. [Expression of myogenin during embryogenesis is controlled by Six/sine oculis homeoproteins through a conserved MEF3 binding site](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62231&geneProductId=UniProtKB:Q62231)
19. [Eya protein phosphatase activity regulates Six1-Dach-Eya transcriptional effects in mammalian organogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62231)
20. [Eya1 regulates the growth of otic epithelium and interacts with Pax2 during the development of all sensory areas in the inner ear](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62231)
21. [Patterning of the third pharyngeal pouch into thymus/parathyroid by Six and Eya1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62231)
22. [Six1 and Six4 promote survival of sensory neurons during early trigeminal gangliogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62231)
23. [Eya1 and Six1 are essential for early steps of sensory neurogenesis in mammalian cranial placodes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62231)
24. [Initiation of olfactory placode development and neurogenesis is blocked in mice lacking both Six1 and Six4](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62231)
25. [Six1 and Six4 homeoproteins are required for Pax3 and Mrf expression during myogenesis in the mouse embryo](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62231)
26. [Six1 regulates Grem1 expression in the metanephric mesenchyme to initiate branching morphogenesis](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62231&geneProductId=UniProtKB:Q62231)
27. [Six1 is required for the early organogenesis of mammalian kidney](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62231)
28. [Eya 1 acts as a critical regulator for specifying the metanephric mesenchyme](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62231)
29. [Six1 and Six4 are essential for Gdnf expression in the metanephric mesenchyme and ureteric bud formation, while Six1 deficiency alone causes mesonephric-tubule defects](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62231)
30. [Six1 and Six4 are essential for Gdnf expression in the metanephric mesenchyme and ureteric bud formation, while Six1 deficiency alone causes mesonephric-tubule defects](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62231&geneProductId=UniProtKB:Q62231)
31. [Six family genes control the proliferation and differentiation of muscle satellite cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62231)
32. [Development of gustatory papillae in the absence of Six1 and Six4](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62231)
33. [Development and differentiation of the ureteric bud into the ureter in the absence of a kidney collecting system](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62231)
34. [Patterning of the third pharyngeal pouch into thymus/parathyroid by Six and Eya1](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62231&geneProductId=UniProtKB:Q62231)
35. [Six1 and Six4 gene expression is necessary to activate the fast-type muscle gene program in the mouse primary myotome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62231)
36. [The role of Six1 in mammalian auditory system development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62231)
37. [A Tbx1-Six1/Eya1-Fgf8 genetic pathway controls mammalian cardiovascular and craniofacial morphogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62231)
38. [Six1 regulates Grem1 expression in the metanephric mesenchyme to initiate branching morphogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62231)
39. [Genesis of muscle fiber-type diversity during mouse embryogenesis relies on Six1 and Six4 gene expression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62231)
40. [Six proteins regulate the activation of Myf5 expression in embryonic mouse limbs](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62231)
41. [Inactivation of Six2 in mouse identifies a novel genetic mechanism controlling development and growth of the cranial base](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62231)
42. [Catweasel mice: a novel role for Six1 in sensory patch development and a model for branchio-oto-renal syndrome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62231)
43. [Six proteins regulate the activation of Myf5 expression in embryonic mouse limbs](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62231&geneProductId=UniProtKB:Q62231)
44. [Six1 and Six4 homeoproteins are required for Pax3 and Mrf expression during myogenesis in the mouse embryo](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62231&geneProductId=UniProtKB:Q62231)
45. ensembl Release 106