Signal transducer and activator of transcription 6
type: Thing
description: mammalian protein found in Mus musculus
additional property: PropertyValue
  property ID: P31
  value: protein
additional property: PropertyValue
  property ID: P279
  value: protein
additional property: PropertyValue
  property ID: P352
  value: P52633
additional property: PropertyValue
  property ID: P361
  value: p53-like transcription factor, DNA-binding
additional property: PropertyValue
  property ID: P361
  value: STAT transcription factor, DNA-binding, N-terminal
additional property: PropertyValue
  property ID: P361
  value: transcription factor STAT
additional property: PropertyValue
  property ID: P527
  value: STAT transcription factor, DNA-binding
additional property: PropertyValue
  property ID: P527
  value: SH2 domain
additional property: PropertyValue
  property ID: P527
  value: STAT transcription factor, all-alpha domain
additional property: PropertyValue
  property ID: P637
  value: NP_033310
additional property: PropertyValue
  property ID: P680
  value: DNA binding
additional property: PropertyValue
  property ID: P680
  value: DNA-binding transcription activator activity, RNA polymerase II-specific
additional property: PropertyValue
  property ID: P680
  value: DNA-binding transcription repressor activity, RNA polymerase II-specific
additional property: PropertyValue
  property ID: P681
  value: nucleoplasm
additional property: PropertyValue
  property ID: P681
  value: cytoplasm
additional property: PropertyValue
  property ID: P681
  value: cytosol
additional property: PropertyValue
  property ID: P682
  value: mammary gland epithelial cell proliferation
additional property: PropertyValue
  property ID: P682
  value: positive regulation of isotype switching to IgE isotypes
additional property: PropertyValue
  property ID: P682
  value: regulation of transcription, DNA-templated
additional property: PropertyValue
  property ID: P702
  value: Stat6
additional property: PropertyValue
  property ID: P703
  value: house mouse
additional property: PropertyValue
  property ID: P705
  value: ENSMUSP00000089708
additional property: PropertyValue
  property ID: P705
  value: ENSMUSP00000112722
confidence:
  popularity graph score:
    score: 0.003
    score pct: 0
    tier: established
    components:
      sitelinks: 0
      sitelinks norm: 0.0
      unique citations: 22
      unique citations norm: 0.009
      monthly pageviews: 0
      monthly pageviews norm: 0.0
  sitelinks: 0
  unique citations: 22
  monthly pageviews: 0
  yearly pageviews: 0
  tier: established
claims:
  P31:
    value: Q8054
    source count: 1
    confidence: 0.2
    value label: protein
  P279:
    value: Q8054
    source count: 1
    confidence: 0.2
    value label: protein
  P352:
    value: P52633
    source count: 1
    confidence: 0.2
  P361:
    value: Q24769358
    source count: 1
    confidence: 0.2
    value label: p53-like transcription factor, DNA-binding
  P361:
    value: Q24784158
    source count: 1
    confidence: 0.2
    value label: STAT transcription factor, DNA-binding, N-terminal
  P361:
    value: Q419333
    source count: 1
    confidence: 0.2
    value label: transcription factor STAT
  P361:
    value: Q24772185
    source count: 1
    confidence: 0.2
    value label: STAT transcription factor, coiled coil
  P361:
    value: Q41797956
    source count: 1
    confidence: 0.2
    value label: SH2 domain superfamily
  P527:
    value: Q24779701
    source count: 1
    confidence: 0.2
    value label: STAT transcription factor, DNA-binding
  P527:
    value: Q24780316
    source count: 1
    confidence: 0.2
    value label: SH2 domain
  P527:
    value: Q24787862
    source count: 1
    confidence: 0.2
    value label: STAT transcription factor, all-alpha domain
  P527:
    value: Q24777206
    source count: 1
    confidence: 0.2
    value label: STAT transcription factor, protein interaction
  P527:
    value: Q24783330
    source count: 1
    confidence: 0.2
    value label: STAT6, C-terminal
  P637:
    value: NP_033310
    source count: 1
    confidence: 0.2
  P680:
    value: Q14633858
    source count: 3
    confidence: 0.6
    value label: DNA binding
  P680:
    value: Q14817973
    source count: 1
    confidence: 0.2
    value label: DNA-binding transcription activator activity, RNA polymerase II-specific
  P680:
    value: Q21097436
    source count: 2
    confidence: 0.4
    value label: DNA-binding transcription repressor activity, RNA polymerase II-specific
  P680:
    value: Q14762994
    source count: 2
    confidence: 0.4
    value label: identical protein binding
  P680:
    value: Q14863060
    source count: 2
    confidence: 0.4
    value label: protein phosphatase binding
  P681:
    value: Q14817956
    source count: 2
    confidence: 0.4
    value label: nucleoplasm
  P681:
    value: Q79899
    source count: 3
    confidence: 0.6
    value label: cytoplasm
  P681:
    value: Q220599
    source count: 2
    confidence: 0.4
    value label: cytosol
  P681:
    value: Q465608
    source count: 2
    confidence: 0.4
    value label: nuclear membrane

value: Q40260
source count: 5
confidence: 1.0
value label: nucleus

value: Q14905565
source count: 1
confidence: 0.2
value label: mammary gland epithelial cell proliferation

value: Q14865943
source count: 1
confidence: 0.2
value label: positive regulation of isotype switching to IgE isotypes

value: Q14633883
source count: 1
confidence: 0.2
value label: regulation of transcription, DNA-templated

value: Q14885182
source count: 3
confidence: 0.6
value label: interleukin-4-mediated signaling pathway

value: Q14865932
source count: 1
confidence: 0.2
value label: T-helper 1 cell lineage commitment

value: Q14914614
source count: 1
confidence: 0.2
value label: Stat6

value: Q83310
source count: 1
confidence: 0.2
value label: house mouse

value: ENSMUSP00000089708
source count: 1
confidence: 0.2

value: ENSMUSP00000112722
source count: 1
confidence: 0.2

source: GOA
stated in qid: Q28018111
retrieved: 2019-05-09

source: Transcriptional repression of Stat6-dependent interleukin-4-induced genes by BCL-6: specific regulation of iepsilon transcription and immunoglobulin E switching
stated in qid: Q24554404
retrieved: 2019-05-09

source: GOA
stated in qid: Q28018111
retrieved: 2018-04-24

source: Selective potentiation of Stat-dependent gene expression by collaborator of Stat6 (CoaSt6), a transcriptional cofactor
stated in qid: Q34573037
retrieved: 2019-05-09

source: The Stat6-regulated KRAB domain zinc finger protein Zfp157 regulates the balance of lineages in mammary glands and compensates for loss of Gata-3
stated in qid: Q28505725
retrieved: 2019-02-14

source: Repression of an interleukin-4-responsive promoter requires cooperative BCL-6 function
stated in qid: Q28593586
retrieved: 2019-05-09

source: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
stated in qid: Q34211397
retrieved: 2019-05-09

source: Proteolytic processing of Stat6 signaling in mast cells as a negative regulatory mechanism
stated in qid: Q28585612
retrieved: 2019-05-09

source: Expression and activation of STAT proteins during mouse retina development
stated in qid: Q28593086
retrieved: 2019-05-09

source: T-cell protein tyrosine phosphatase, distinctively expressed in activated-B-cell-like diffuse large B-cell lymphomas, is the nuclear phosphatase of STAT6
stated in qid: Q24338883
retrieved: 2019-05-09

source: The sequential activity of Gata3 and Thpok is required for the differentiation of CD1d-restricted CD4+ NKT cells
stated in qid: Q28585176
retrieved: 2019-05-09

source: IL-4 inhibits TGF-beta-induced Foxp3+ T cells and, together with TGF-beta, generates IL-9+ IL-10+ Foxp3(-) effector T cells
stated in qid: Q28590243
retrieved: 2019-05-09

source: STAT6-mediated displacement of polycomb by trithorax complex establishes long-term maintenance of GATA3 expression in T helper type 2 cells
stated in qid: Q28510023
retrieved: 2019-05-09

source: BCL-6-deficient mice reveal an IL-4-independent, STAT6-dependent pathway that controls susceptibility to infection by Leishmania major
stated in qid: Q28513511
retrieved: 2019-05-09

source: Direct regulation of Gata3 expression determines the T helper differentiation potential of Notch
stated in qid: Q28594879
retrieved: 2019-05-09

source: ECM1 controls TH2 cell egress from lymph nodes through re-expression of S1P1
stated in qid: Q28586577
retrieved: 2019-02-14

source: Control of inflammation, cytokine expression, and germinal center formation by BCL-6
stated in qid: Q28585541
retrieved: 2019-02-14

source: Eosinophils and type 2 cytokine signaling in macrophages orchestrate development of functional beige fat.
stated in qid: Q34031152
retrieved: 2019-05-09

source: InterPro Release 71.0
stated in qid: Q58943792

source: UniProt
stated in qid: Q905695
retrieved: 2022-05-25

source: Q20641742
stated in qid: Q20641742
retrieved: 2022-03-20

source: ensembl Release 106
stated in qid: Q111699881

wikidata id: Q14914616
domain: protein
level: standard
html url: https://4ort.xyz/entity/signal-transducer-and-activator-of-transcription-6
markdown url: https://4ort.xyz/entity/signal-transducer-and-activator-of-transcription-6.md
facts url summary: https://4ort.xyz/entity/signal-transducer-and-activator-of-transcription-6/facts.json
facts url standard: https://4ort.xyz/entity/signal-transducer-and-activator-of-transcription-6/facts.json
facts url full: https://4ort.xyz/entity/signal-transducer-and-activator-of-transcription-6/facts.json
data source: Wikidata (CC0 / public domain)
license: https://creativecommons.org/publicdomain/zero/1.0/
api version: v1
served at: 2026-08-06T11:05:32.662149Z
entity updated at: 2026-05-03T18:28:36.114423+00:00Z
entity created at: 2026-05-03T13:57:37.732274+00:00Z