Signal transducer and activator of transcription 6
type: Thing
description: mammalian protein found in Rattus norvegicus
additional property: PropertyValue
  property ID: P31
  value: protein
additional property: PropertyValue
  property ID: P361
  value: p53-like transcription factor, DNA-binding
additional property: PropertyValue
  property ID: P361
  value: STAT transcription factor, DNA-binding, N-terminal
additional property: PropertyValue
  property ID: P361
  value: transcription factor STAT
additional property: PropertyValue
  property ID: P527
  value: STAT transcription factor, DNA-binding
additional property: PropertyValue
  property ID: P527
  value: STAT transcription factor, all-alpha domain
additional property: PropertyValue
  property ID: P527
  value: STAT6, C-terminal
additional property: PropertyValue
  property ID: P637
  value: NP_001037715
additional property: PropertyValue
  property ID: P680
  value: RNA polymerase II transcription regulatory region sequence-specific DNA binding
additional property: PropertyValue
  property ID: P680
  value: RNA polymerase II cis-regulatory region sequence-specific DNA binding
additional property: PropertyValue
  property ID: P680
  value: DNA-binding transcription activator activity, RNA polymerase II-specific
additional property: PropertyValue
  property ID: P681
  value: nucleus
additional property: PropertyValue
  property ID: P681
  value: nucleoplasm
additional property: PropertyValue
  property ID: P681
  value: cytoplasm
additional property: PropertyValue
  property ID: P682
  value: negative regulation of transcription by RNA polymerase II
additional property: PropertyValue
  property ID: P682
  value: T-helper 1 cell lineage commitment
additional property: PropertyValue
  property ID: P682
  value: negative regulation of type 2 immune response
additional property: PropertyValue
  property ID: P702
  value: Stat6
additional property: PropertyValue
  property ID: P703
  value: brown rat
additional property: PropertyValue
  property ID: P705
  value: ENSRNOP00000072301
confidence:
  popularity graph score:
    score: 0.002
    score pct: 0
    tier: established
    components:
      sitelinks: 0
      sitelinks norm: 0.0
      unique citations: 11
      unique citations norm: 0.004
      monthly pageviews: 0
      monthly pageviews norm: 0.0
  sitelinks: 0
  unique citations: 11
  monthly pageviews: 0
  yearly pageviews: 0
  tier: established
claims:
  P31:
    value: Q8054
    source count: 1
    confidence: 0.2
    value label: protein
  P352:
    value: Q1KQ07
    source count: 1
    confidence: 0.2
  P361:
    value: Q24769358
    source count: 1
    confidence: 0.2
    value label: p53-like transcription factor, DNA-binding
  P361:
    value: Q24784158
    source count: 1
    confidence: 0.2
    value label: STAT transcription factor, DNA-binding, N-terminal
  P361:
    value: Q419333
    source count: 1
    confidence: 0.2
    value label: transcription factor STAT
  P361:
    value: Q24772185
    source count: 1
    confidence: 0.2
    value label: STAT transcription factor, coiled coil
  P361:
    value: Q41797956
    source count: 1
    confidence: 0.2
    value label: SH2 domain superfamily
  P527:
    value: Q24779701
    source count: 1
    confidence: 0.2
    value label: STAT transcription factor, DNA-binding
  P527:
    value: Q24787862
    source count: 1
    confidence: 0.2
    value label: STAT transcription factor, all-alpha domain
  P527:
    value: Q24783330
    source count: 1
    confidence: 0.2
    value label: STAT6, C-terminal
  P527:
    value: Q24777206
    source count: 1
    confidence: 0.2
    value label: STAT transcription factor, protein interaction
  P527:
    value: Q24780316
    source count: 1
    confidence: 0.2
    value label: SH2 domain
  P637:
    value: NP_001037715
    source count: 1
    confidence: 0.2
  P680:
    value: Q14864823
    source count: 1
    confidence: 0.2
    value label: RNA polymerase II transcription regulatory region sequence-specific DNA binding
  P680:
    value: Q14885806
    source count: 1
    confidence: 0.2
    value label: RNA polymerase II cis-regulatory region sequence-specific DNA binding
  P680:
    value: Q14817973
    source count: 1
    confidence: 0.2
    value label: DNA-binding transcription activator activity, RNA polymerase II-specific
  P680:
    value: Q14633858
    source count: 3
    confidence: 0.6
    value label: DNA binding
  P680:
    value: Q14817979
    source count: 2
    confidence: 0.4
    value label: DNA-binding transcription factor activity
  P681:
    value: Q40260
    source count: 4
    confidence: 0.8
    value label: nucleus
  P681:
    value: Q14817956
    source count: 1
    confidence: 0.2
    value label: nucleoplasm
  P681:
    value: Q79899
    source count: 2
    confidence: 0.4
    value label: cytoplasm
  P681:
    value: Q220599
    source count: 1
    confidence: 0.2
    value label: cytosol
  P681:
    value: Q465608
    source count: 1
    confidence: 0.2
    value label: nuclear membrane
  P682:
    value: Q14633878
    source count: 1
    confidence: 0.2
    value label: negative regulation of transcription by RNA polymerase II
  P682:
    value: Q14865932
    source count: 1
    confidence: 0.2
    value label: T-helper 1 cell lineage commitment

value: Q14907231
source count: 1
confidence: 0.2
value label: negative regulation of type 2 immune response

value: Q14633883
source count: 1
confidence: 0.2
value label: regulation of transcription, DNA-templated

value: Q828130
source count: 2
confidence: 0.4
value label: signal transduction

value: Q24424566
source count: 1
confidence: 0.2
value label: Stat6

value: Q184224
source count: 1
confidence: 0.2
value label: brown rat

value: ENSRNOP00000072301
source count: 1
confidence: 0.2

source: GOA
stated in qid: Q28018111
retrieved: 2019-05-09

source: STAT6 transcription factor binding sites with mismatches within the canonical 5'-TTC...GAA-3' motif involved in regulation of delta- and mu-opioid receptors
stated in qid: Q28570977
retrieved: 2019-05-09

source: Peptide YY attenuates STAT1 and STAT3 activation induced by TNF-alpha in acinar cell line AR42J
stated in qid: Q28582118
retrieved: 2019-05-09

source: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
stated in qid: Q34211397
retrieved: 2019-05-09

source: Astrocytes, but not microglia, rapidly sense H₂O₂via STAT6 phosphorylation, resulting in cyclooxygenase-2 expression and prostaglandin release
stated in qid: Q28570231
retrieved: 2019-05-09

source: Mechanical stretch and angiotensin II increase interleukin-13 production and interleukin-13 receptor alpha2 expression in rat neonatal cardiomyocytes
stated in qid: Q28573617
retrieved: 2019-02-14

source: Eosinophils and type 2 cytokine signaling in macrophages orchestrate development of functional beige fat.
stated in qid: Q34031152
retrieved: 2019-05-09

source: InterPro Release 71.0
stated in qid: Q58943792

source: UniProt
stated in qid: Q905695
retrieved: 2021-11-17

source: Q20641742
stated in qid: Q20641742
retrieved: 2022-03-20

source: ensembl Release 106
stated in qid: Q111699881

wikidata id: Q29526007
domain: protein
level: standard
html url: https://4ort.xyz/entity/signal-transducer-and-activator-of-transcription-6-q29526007
markdown url: https://4ort.xyz/entity/signal-transducer-and-activator-of-transcription-6-q29526007.md
facts url summary: https://4ort.xyz/entity/signal-transducer-and-activator-of-transcription-6-q29526007/facts.json
facts url standard: https://4ort.xyz/entity/signal-transducer-and-activator-of-transcription-6-q29526007/facts.json
facts url full: https://4ort.xyz/entity/signal-transducer-and-activator-of-transcription-6-q29526007/facts.json
data source: Wikidata (CC0 / public domain)
license: https://creativecommons.org/publicdomain/zero/1.0/
api version: v1
served at: 2026-08-12T18:46:55.867526Z
entity updated at: 2026-05-03T18:28:36.114423+00:00Z
entity created at: 2026-05-03T14:42:22.550026+00:00Z