Signal transducer and activator of transcription 5A
type: Thing
description: mammalian protein found in Mus musculus
additional property: PropertyValue
  property ID: P31
  value: protein
additional property: PropertyValue
  property ID: P279
  value: protein
additional property: PropertyValue
  property ID: P352
  value: P42230
additional property: PropertyValue
  property ID: P361
  value: p53-like transcription factor, DNA-binding
additional property: PropertyValue
  property ID: P361
  value: STAT5
additional property: PropertyValue
  property ID: P361
  value: STAT transcription factor, DNA-binding, N-terminal
additional property: PropertyValue
  property ID: P527
  value: STAT transcription factor, DNA-binding
additional property: PropertyValue
  property ID: P527
  value: SH2 domain
additional property: PropertyValue
  property ID: P527
  value: STAT transcription factor, all-alpha domain
additional property: PropertyValue
  property ID: P637
  value: NP_001157534
additional property: PropertyValue
  property ID: P637
  value: NP_035618
additional property: PropertyValue
  property ID: P637
  value: XP_006532784
additional property: PropertyValue
  property ID: P638
  value: 1Y1U
additional property: PropertyValue
  property ID: P680
  value: DNA binding
additional property: PropertyValue
  property ID: P680
  value: protein binding
additional property: PropertyValue
  property ID: P680
  value: DNA-binding transcription activator activity, RNA polymerase II-specific
additional property: PropertyValue
  property ID: P681
  value: nucleoplasm
additional property: PropertyValue
  property ID: P681
  value: cytosol
additional property: PropertyValue
  property ID: P681
  value: nucleus
additional property: PropertyValue
  property ID: P682
  value: luteinization
additional property: PropertyValue
  property ID: P682
  value: positive regulation of inflammatory response
additional property: PropertyValue
  property ID: P682
  value: regulation of transcription, DNA-templated
additional property: PropertyValue
  property ID: P702
  value: Stat5a
additional property: PropertyValue
  property ID: P703
  value: house mouse
additional property: PropertyValue
  property ID: P705
  value: ENSMUSP00000004145
additional property: PropertyValue
  property ID: P705
  value: ENSMUSP00000102979
additional property: PropertyValue
  property ID: P705
  value: ENSMUSP00000102980
confidence:
  popularity graph score:
    score: 0.005
    score pct: 1
    tier: established
    components:
      sitelinks: 0
      sitelinks norm: 0.0
      unique citations: 37
      unique citations norm: 0.015
      monthly pageviews: 0
      monthly pageviews norm: 0.0
  sitelinks: 0
  unique citations: 37
  monthly pageviews: 0
  yearly pageviews: 0
  tier: established
claims:
  P31:
    value: Q8054
    source count: 1
    confidence: 0.2
    value label: protein
  P279:
    value: Q8054
    source count: 1
    confidence: 0.2
    value label: protein
  P352:
    value: P42230
    source count: 1
    confidence: 0.2
  P361:
    value: Q24769358
    source count: 1
    confidence: 0.2
    value label: p53-like transcription factor, DNA-binding
  P361:
    value: Q4210018
    source count: 1
    confidence: 0.2
    value label: STAT5
  P361:
    value: Q24784158
    source count: 1
    confidence: 0.2
    value label: STAT transcription factor, DNA-binding, N-terminal
  P361:
    value: Q24772185
    source count: 1
    confidence: 0.2
    value label: STAT transcription factor, coiled coil
  P361:
    value: Q41797956
    source count: 1
    confidence: 0.2
    value label: SH2 domain superfamily
  P527:
    value: Q24779701
    source count: 1
    confidence: 0.2
    value label: STAT transcription factor, DNA-binding
  P527:
    value: Q24780316
    source count: 1
    confidence: 0.2
    value label: SH2 domain
  P527:
    value: Q24787862
    source count: 1
    confidence: 0.2
    value label: STAT transcription factor, all-alpha domain
  P527:
    value: Q24777206
    source count: 1
    confidence: 0.2
    value label: STAT transcription factor, protein interaction
  P637:
    value: NP_001157534
    source count: 1
    confidence: 0.2
  P637:
    value: NP_035618
    source count: 1
    confidence: 0.2
  P637:
    value: XP_006532784
    source count: 1
    confidence: 0.2
  P637:
    value: XP_017169891
    source count: 1
    confidence: 0.2
  P637:
    value: NP_001349609
    source count: 1
    confidence: 0.2
  P638:
    value: 1Y1U
    source count: 1
    confidence: 0.2
  P680:
    value: Q14633858
    source count: 5
    confidence: 1.0
    value label: DNA binding
  P680:
    value: Q167149
    source count: 6
    confidence: 1.0
    value label: protein binding
  P680:
    value: Q14817973
    source count: 2
    confidence: 0.4
    value label: DNA-binding transcription activator activity, RNA polymerase II-specific
  P680:
    value: Q14885806
    source count: 1
    confidence: 0.2
    value label: RNA polymerase II cis-regulatory region sequence-specific DNA binding

value: Q14818104
source count: 1
confidence: 0.2
value label: double-stranded DNA binding

value: Q14817956
source count: 2
confidence: 0.4
value label: nucleoplasm

value: Q220599
source count: 2
confidence: 0.4
value label: cytosol

value: Q40260
source count: 4
confidence: 0.8
value label: nucleus

value: Q79899
source count: 4
confidence: 0.8
value label: cytoplasm

value: Q40260
source count: 5
confidence: 1.0
value label: nucleus

value: Q15312522
source count: 1
confidence: 0.2
value label: luteinization

value: Q14859639
source count: 1
confidence: 0.2
value label: positive regulation of inflammatory response

value: Q14633883
source count: 1
confidence: 0.2
value label: regulation of transcription, DNA-templated

value: Q14907616
source count: 1
confidence: 0.2
value label: allantoin metabolic process

value: Q14873011
source count: 1
confidence: 0.2
value label: epithelial cell differentiation involved in prostate gland development

value: Q18254363
source count: 1
confidence: 0.2
value label: Stat5a

value: Q83310
source count: 1
confidence: 0.2
value label: house mouse

value: ENSMUSP00000004145
source count: 1
confidence: 0.2

value: ENSMUSP00000102979
source count: 1
confidence: 0.2

value: ENSMUSP00000102980
source count: 1
confidence: 0.2

value: ENSMUSP00000117204
source count: 1
confidence: 0.2

value: ENSMUSP00000120039
source count: 1
confidence: 0.2

source: GOA
stated in qid: Q28018111
retrieved: 2019-05-09

source: Effects of hyperactive Janus kinase 2 signaling in mammary epithelial cells
stated in qid: Q28585551
retrieved: 2019-05-09

source: Caveolin-1-deficient mice show accelerated mammary gland development during pregnancy, premature lactation, and hyperactivation of the Jak-2/STAT5a signaling cascade.
stated in qid: Q24311717
retrieved: 2019-05-09

source: Stat5 activation is uniquely associated with cytokine signaling in peripheral T cells
stated in qid: Q28511057
retrieved: 2019-05-09

source: CPAP is a novel stat5-interacting cofactor that augments stat5-mediated transcriptional activity
stated in qid: Q28219201
retrieved: 2019-05-09

source: Pecam-1 is a modulator of stat family member phosphorylation and localization: lessons from a transgenic mouse
stated in qid: Q28585431
retrieved: 2019-05-09

source: PIKE-A is required for prolactin-mediated STAT5a activation in mammary gland development
stated in qid: Q24295182
retrieved: 2019-05-09

source: Mammalian protein-protein interaction trap (MAPPIT) analysis of STAT5, CIS, and SOCS2 interactions with the growth hormone receptor
stated in qid: Q28512825
retrieved: 2019-05-09

source: Growth hormone promotes the association of transcription factor STAT5 with the growth hormone receptor
stated in qid: Q28590660
retrieved: 2019-05-09

source: IL-3-induced enhancement of retinoic acid receptor activity is mediated through Stat5, which physically associates with retinoic acid receptors in an IL-3-dependent manner
stated in qid: Q28771507
retrieved: 2019-02-14

source: IL-1 family members and STAT activators induce cytokine production by Th2, Th17, and Th1 cells
stated in qid: Q24652221
retrieved: 2019-02-14

source: Stat5 activation is uniquely associated with cytokine signaling in peripheral T cells
stated in qid: Q28511057
retrieved: 2018-04-24

source: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
stated in qid: Q34211397
retrieved: 2019-05-09

source: Mammary epithelial cells are not able to undergo pregnancy-dependent differentiation in the absence of the helix-loop-helix inhibitor Id2
stated in qid: Q28507234
retrieved: 2019-02-14

source: Beta1 integrins regulate chondrocyte rotation, G1 progression, and cytokinesis
stated in qid: Q28508685
retrieved: 2019-05-09

source: Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses
stated in qid: Q28592023
retrieved: 2019-05-09

source: Antiapoptotic activity of Stat5 required during terminal stages of myeloid differentiation
stated in qid: Q22011170
retrieved: 2019-05-09

source: Altered metabolism of growth hormone receptor mutant mice: a combined NMR metabonomics and microarray study
stated in qid: Q28504973
retrieved: 2018-04-24

source: Epithelial defect in prostates of Stat5a-null mice
stated in qid: Q28594722
retrieved: 2019-05-09

source: Stat5b is essential for natural killer cell-mediated proliferation and cytolytic activity
stated in qid: Q28586849
retrieved: 2019-05-09

source: STAT5 is required for thymopoiesis in a development stage-specific manner
stated in qid: Q28592686
retrieved: 2019-05-09

source: Mouse mammary epithelial cells express the Na-K-Cl cotransporter, NKCC1: characterization, localization, and involvement in ductal development and morphogenesis
stated in qid: Q28512339
retrieved: 2019-05-09

source: ECM1 controls TH2 cell egress from lymph nodes through re-expression of S1P1
stated in qid: Q28586577
retrieved: 2019-05-09

source: Stat5a/b contribute to interleukin 7-induced B-cell precursor expansion, but abl- and bcr/abl-induced transformation are independent of stat5
stated in qid: Q28508796
retrieved: 2019-05-09

source: Regulation of progesterone levels during pregnancy and parturition by signal transducer and activator of transcription 5 and 20alpha-hydroxysteroid dehydrogenase
stated in qid: Q28589948
retrieved: 2019-05-09

source: JANEX-1, a JAK3 inhibitor, protects pancreatic islets from cytokine toxicity through downregulation of NF-kappaB activation and the JAK/STAT pathway
stated in qid: Q28567187
retrieved: 2019-05-09

source: Stat5a is essential for the proliferation and survival of murine mast cells
stated in qid: Q28508193
retrieved: 2019-05-09

source: Stat5 is required for IL-2-induced cell cycle progression of peripheral T cells
stated in qid: Q22009002
retrieved: 2019-05-09

source: GOA
stated in qid: Q28018111
retrieved: 2018-04-24

source: Signal transducer and activator of transcription (Stat) 5 controls the proliferation and differentiation of mammary alveolar epithelium
stated in qid: Q28513906
retrieved: 2019-05-09

wikidata id: Q21498877
domain: protein
level: standard
html url: https://4ort.xyz/entity/signal-transducer-and-activator-of-transcription-5a
markdown url: https://4ort.xyz/entity/signal-transducer-and-activator-of-transcription-5a.md
facts url summary: https://4ort.xyz/entity/signal-transducer-and-activator-of-transcription-5a/facts.json
facts url standard: https://4ort.xyz/entity/signal-transducer-and-activator-of-transcription-5a/facts.json
facts url full: https://4ort.xyz/entity/signal-transducer-and-activator-of-transcription-5a/facts.json
data source: Wikidata (CC0 / public domain)
license: https://creativecommons.org/publicdomain/zero/1.0/
api version: v1
served at: 2026-08-06T08:30:40.942115Z
entity updated at: 2026-05-03T18:28:36.114423+00:00Z
entity created at: 2026-05-03T13:58:50.900290+00:00Z