# signal transducer and activator of transcription 3

> mammalian protein found in Homo sapiens

**Wikidata**: [Q4210010](https://www.wikidata.org/wiki/Q4210010)  
**Source**: https://4ort.xyz/entity/signal-transducer-and-activator-of-transcription-3


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P40763)
3. Q20641742
4. Freebase Data Dumps. 2013
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763)
6. [STAT3beta, a splice variant of transcription factor STAT3, is a dominant negative regulator of transcription](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763)
7. [Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763)
8. [leptin-induced growth stimulation of breast cancer cells involves recruitment of histone acetyltransferases and mediator complex to CYCLIN D1 promoter via activation of Stat3](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763)
9. [STAT3 mediates hepatic hepcidin expression and its inflammatory stimulation](http://www.ebi.ac.uk/QuickGO/annotations?protein=P40763&geneProductId=UniProtKB:P40763)
10. [Interleukin-6 transcriptionally regulates prohibitin expression in intestinal epithelial cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763)
11. [The nuclear isoform of protein-tyrosine phosphatase TC-PTP regulates interleukin-6-mediated signaling pathway through STAT3 dephosphorylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763)
12. [Identification of STAT3 as a substrate of receptor protein tyrosine phosphatase T](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763)
13. [Interleukin-6 modulates the expression of the bone morphogenic protein receptor type II through a novel STAT3-microRNA cluster 17/92 pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763)
14. [Tid1 isoforms are mitochondrial DnaJ-like chaperones with unique carboxyl termini that determine cytosolic fate](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763)
15. [Acetylation Directs Survivin Nuclear Localization to Repress STAT3 Oncogenic Activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763)
16. [Lysyl Oxidase 3 Is a Dual-Specificity Enzyme Involved in STAT3 Deacetylation and Deacetylimination Modulation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763)
17. [Identification of STAT3 as a specific substrate of breast tumor kinase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763)
18. [The cell death regulator GRIM-19 is an inhibitor of signal transducer and activator of transcription 3](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763)
19. [Respiratory syncytial virus-inducible BCL-3 expression antagonizes the STAT/IRF and NF-kappaB signaling pathways by inducing histone deacetylase 1 recruitment to the interleukin-8 promoter](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763)
20. [BART is essential for nuclear retention of STAT3](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763)
21. [Reactive Oxygen Species (ROS) Mediate p300-dependent STAT1 Protein Interaction with Peroxisome Proliferator-activated Receptor (PPAR)-γ in CD36 Protein Expression and Foam Cell Formation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763)
22. [Etk, a Btk family tyrosine kinase, mediates cellular transformation by linking Src to STAT3 activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763)
23. [JAK/STAT3 pathway is involved in survival of neurons in response to insulin-like growth factor and negatively regulated by suppressor of cytokine signaling-3](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763)
24. [Inositol Polyphosphate-5-Phosphatase F (INPP5F) inhibits STAT3 activity and suppresses gliomas tumorigenicity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763)
25. [MEN2A-RET-induced cellular transformation by activation of STAT3](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763)
26. [Perturbation of the mutated EGFR interactome identifies vulnerabilities and resistance mechanisms](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763)
27. [A quantitative protein interaction network for the ErbB receptors using protein microarrays](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763)
28. [PTP1B regulates leptin signal transduction in vivo](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763)
29. [Novel role of signal transducer and activator of transcription 3 as a progesterone receptor coactivator in breast cancer](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763)
30. [A proteome-scale map of the human interactome network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763)
31. [Next-generation sequencing to generate interactome datasets](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763)
32. [STAT3 regulates Nemo-like kinase by mediating its interaction with IL-6-stimulated TGFbeta-activated kinase 1 for STAT3 Ser-727 phosphorylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763)
33. [Implication of BRG1 and cdk9 in the STAT3-mediated activation of the p21waf1 gene](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763)
34. [Peroxiredoxin-2 and STAT3 form a redox relay for H2O2 signaling.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763)
35. [ErbB-2 activates Stat3 alpha in a Src- and JAK2-dependent manner](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763)
36. [Phosphotyrosine signaling networks in epidermal growth factor receptor overexpressing squamous carcinoma cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763)
37. [Physical and functional interactions between STAT3 and Kaposi's sarcoma-associated herpesvirus-encoded LANA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763)
38. [ECHS1 interacts with STAT3 and negatively regulates STAT3 signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763)
39. [SH2B1β Interacts with STAT3 and Enhances Fibroblast Growth Factor 1-Induced Gene Expression during Neuronal Differentiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763)
40. [Physical and functional interactions between Daxx and STAT3](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763)
41. [PIPINO: A Software Package to Facilitate the Identification of Protein-Protein Interactions from Affinity Purification Mass Spectrometry Data](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763)
42. [ErbB2-mediated Src and signal transducer and activator of transcription 3 activation leads to transcriptional up-regulation of p21Cip1 and chemoresistance in breast cancer cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763)
43. [Persistently activated Stat3 maintains constitutive NF-kappaB activity in tumors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763)
44. [Mechanism of protein tyrosine phosphatase 1B-mediated inhibition of leptin signalling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763)
45. [Progesterone receptor induces ErbB-2 nuclear translocation to promote breast cancer growth via a novel transcriptional effect: ErbB-2 function as a coactivator of Stat3](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763)
46. [Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763)
47. [Crif1 is a novel transcriptional coactivator of STAT3](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763)
48. [Structural requirements for signal transducer and activator of transcription 3 binding to phosphotyrosine ligands containing the YXXQ motif](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763)
49. [Phosphorylation of EZH2 Activates STAT3 Signaling via STAT3 Methylation and Promotes Tumorigenicity of Glioblastoma Stem-like Cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763)
50. [EGFR phosphorylates tumor-derived EGFRvIII driving STAT3/5 and progression in glioblastoma](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763)