# Signal transducer and activator of transcription 3

> mammalian protein found in Mus musculus

**Wikidata**: [Q14912021](https://www.wikidata.org/wiki/Q14912021)  
**Source**: https://4ort.xyz/entity/signal-transducer-and-activator-of-transcription-3-q14912021


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P42227)
3. Q20641742
4. [Phosphotyrosyl peptides block Stat3-mediated DNA binding activity, gene regulation, and cell transformation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227)
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227)
6. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P42227&geneProductId=UniProtKB:P42227)
7. [Conserved Regulation of the JAK/STAT Pathway by the Endosomal Protein Asrij Maintains Stem Cell Potency](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227)
8. [Hes binding to STAT3 mediates crosstalk between Notch and JAK-STAT signalling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227)
9. [The PINIT domain of PIAS3: structure-function analysis of its interaction with STAT3](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227)
10. [BART is essential for nuclear retention of STAT3](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227)
11. [A novel nuclear zinc finger protein EZI enhances nuclear retention and transactivation of STAT3](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227)
12. [Cross-talk between KLF4 and STAT3 regulates axon regeneration](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227)
13. [The LIM/homeodomain protein Islet1 recruits Janus tyrosine kinases and signal transducer and activator of transcription 3 and stimulates their activities](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227)
14. [Nuclear termination of STAT3 signaling through SIPAR (STAT3‐Interacting Protein As a Repressor)‐dependent recruitment of T cell tyrosine phosphatase TC‐PTP](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227)
15. [Nanog binds to Smad1 and blocks bone morphogenetic protein-induced differentiation of embryonic stem cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227)
16. [Hepcidin mediates transcriptional changes that modulate acute cytokine-induced inflammatory responses in mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227)
17. [A Stat3-interacting protein (StIP1) regulates cytokine signal transduction](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227)
18. [Pecam-1 is a modulator of stat family member phosphorylation and localization: lessons from a transgenic mouse](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227)
19. [Cyclin-dependent kinase 5 phosphorylates signal transducer and activator of transcription 3 and regulates its transcriptional activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227)
20. [Fer is a downstream effector of insulin and mediates the activation of signal transducer and activator of transcription 3 in myogenic cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227)
21. [STAT3 is a substrate of SYK tyrosine kinase in B-lineage leukemia/lymphoma cells exposed to oxidative stress](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227)
22. [Bioinformatics and cellular signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227)
23. [Crif1 is a novel transcriptional coactivator of STAT3](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227)
24. [SH2B1β Interacts with STAT3 and Enhances Fibroblast Growth Factor 1-Induced Gene Expression during Neuronal Differentiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227)
25. [Novel role of signal transducer and activator of transcription 3 as a progesterone receptor coactivator in breast cancer](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227)
26. [ECHS1 interacts with STAT3 and negatively regulates STAT3 signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227)
27. [Sinomenine activates astrocytic dopamine D2 receptors and alleviates neuroinflammatory injury via the CRYAB/STAT3 pathway after ischemic stroke in mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227)
28. [A kinase-independent function of CDK6 links the cell cycle to tumor angiogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227)
29. [Differential activation of acute phase response factor/STAT3 and STAT1 via the cytoplasmic domain of the interleukin 6 signal transducer gp130. I. Definition of a novel phosphotyrosine motif mediating STAT1 activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227)
30. [Progesterone receptor induces ErbB-2 nuclear translocation to promote breast cancer growth via a novel transcriptional effect: ErbB-2 function as a coactivator of Stat3](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227)
31. [The coiled-coil domain of Stat3 is essential for its SH2 domain-mediated receptor binding and subsequent activation induced by epidermal growth factor and interleukin-6](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227)
32. [Physical and functional interactions between STAT3 and ZIP kinase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227)
33. [Role of the TAK1-NLK-STAT3 pathway in TGF-beta-mediated mesoderm induction](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227)
34. [Lysyl Oxidase 3 Is a Dual-Specificity Enzyme Involved in STAT3 Deacetylation and Deacetylimination Modulation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227)
35. [Observation of unphosphorylated STAT3 core protein binding to target dsDNA by PEMSA and X‐ray crystallography](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227)
36. [Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227)
37. [A Novel Sequence in the Coiled-coil Domain of Stat3 Essential for Its Nuclear Translocation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227)
38. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227)
39. [Expression of Stat3 in germ cells of developing and adult mouse ovaries and testes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227)
40. [Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227)
41. [Expression and activation of STAT proteins during mouse retina development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227)
42. [Leptin downregulates expression of the gene encoding glucagon in alphaTC1-9 cells and mouse islets](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227)
43. [Effects of leptin and leukemia inhibitory factor on preimplantation development and STAT3 signaling of mouse embryos in vitro](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227)
44. [STAT3 negatively regulates thyroid tumorigenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227)
45. [Tumor necrosis factor receptor signaling in keratinocytes triggers interleukin-24-dependent psoriasis-like skin inflammation in mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227)
46. [The metabolite GnRH-(1-5) inhibits the migration of immortalized GnRH neurons](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227)
47. [Signal transducers and activators of transcription 3 augments the transcriptional activity of CCAAT/enhancer-binding protein alpha in granulocyte colony-stimulating factor signaling pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227)
48. [Disruption of neural signal transducer and activator of transcription 3 causes obesity, diabetes, infertility, and thermal dysregulation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227)
49. [Innate Stat3-mediated induction of the antimicrobial protein Reg3γ is required for host defense against MRSA pneumonia](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227)
50. [STAT3 signalling is required for leptin regulation of energy balance but not reproduction](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227)