Signal transducer and activator of transcription 1
type: Thing
description: mammalian protein found in Homo sapiens
additional property: PropertyValue
  property ID: P31
  value: protein
additional property: PropertyValue
  property ID: P352
  value: P42224
additional property: PropertyValue
  property ID: P361
  value: p53-like transcription factor, DNA-binding
additional property: PropertyValue
  property ID: P361
  value: STAT transcription factor, DNA-binding, N-terminal
additional property: PropertyValue
  property ID: P361
  value: transcription factor STAT
additional property: PropertyValue
  property ID: P486
  value: D050794
additional property: PropertyValue
  property ID: P527
  value: Signal transducer and activation of transcription 1, TAZ2 binding domain, C-terminal
additional property: PropertyValue
  property ID: P527
  value: SH2 domain
additional property: PropertyValue
  property ID: P527
  value: STAT transcription factor, all-alpha domain
additional property: PropertyValue
  property ID: P637
  value: NP_009330
additional property: PropertyValue
  property ID: P637
  value: NP_644671
additional property: PropertyValue
  property ID: P637
  value: XP_006712781
additional property: PropertyValue
  property ID: P638
  value: 3WWT
additional property: PropertyValue
  property ID: P638
  value: 1BF5
additional property: PropertyValue
  property ID: P638
  value: 1YVL
additional property: PropertyValue
  property ID: P672
  value: D12.644.360.024.303.500.500
additional property: PropertyValue
  property ID: P672
  value: D12.644.360.024.342.100
additional property: PropertyValue
  property ID: P672
  value: D12.776.157.057.061.500.500
additional property: PropertyValue
  property ID: P680
  value: DNA binding
additional property: PropertyValue
  property ID: P680
  value: protein homodimerization activity
additional property: PropertyValue
  property ID: P680
  value: DNA-binding transcription factor activity
additional property: PropertyValue
  property ID: P681
  value: cytoplasm
additional property: PropertyValue
  property ID: P681
  value: nucleoplasm
additional property: PropertyValue
  property ID: P681
  value: nucleolus
additional property: PropertyValue
  property ID: P682
  value: regulation of apoptotic process
additional property: PropertyValue
  property ID: P682
  value: metanephric mesenchymal cell proliferation involved in metanephros development
additional property: PropertyValue
  property ID: P682
  value: regulation of transcription, DNA-templated
additional property: PropertyValue
  property ID: P692
  value: PBB GE STAT1 200887 s at fs.png
additional property: PropertyValue
  property ID: P702
  value: STAT1
additional property: PropertyValue
  property ID: P703
  value: Homo sapiens
confidence:
  popularity graph score:
    score: 0.009
    score pct: 1
    tier: established
    components:
      sitelinks: 0
      sitelinks norm: 0.0
      unique citations: 62
      unique citations norm: 0.024
      monthly pageviews: 0
      monthly pageviews norm: 0.0
  sitelinks: 0
  unique citations: 62
  monthly pageviews: 0
  yearly pageviews: 0
  tier: established
claims:
  P31:
    value: Q8054
    source count: 1
    confidence: 0.2
    value label: protein
  P352:
    value: P42224
    source count: 1
    confidence: 0.2
  P361:
    value: Q24769358
    source count: 1
    confidence: 0.2
    value label: p53-like transcription factor, DNA-binding
  P361:
    value: Q24784158
    source count: 1
    confidence: 0.2
    value label: STAT transcription factor, DNA-binding, N-terminal
  P361:
    value: Q419333
    source count: 1
    confidence: 0.2
    value label: transcription factor STAT
  P361:
    value: Q24772185
    source count: 1
    confidence: 0.2
    value label: STAT transcription factor, coiled coil
  P361:
    value: Q41797956
    source count: 1
    confidence: 0.2
    value label: SH2 domain superfamily
  P486:
    value: D050794
    source count: 0
    confidence: 0.0
  P527:
    value: Q24774414
    source count: 1
    confidence: 0.2
    value label: Signal transducer and activation of transcription 1, TAZ2 binding domain, C-terminal
  P527:
    value: Q24780316
    source count: 1
    confidence: 0.2
    value label: SH2 domain
  P527:
    value: Q24787862
    source count: 1
    confidence: 0.2
    value label: STAT transcription factor, all-alpha domain
  P527:
    value: Q24779701
    source count: 1
    confidence: 0.2
    value label: STAT transcription factor, DNA-binding
  P527:
    value: Q24777206
    source count: 1
    confidence: 0.2
    value label: STAT transcription factor, protein interaction
  P637:
    value: NP_009330
    source count: 1
    confidence: 0.2
  P637:
    value: NP_644671
    source count: 1
    confidence: 0.2
  P637:
    value: XP_006712781
    source count: 1
    confidence: 0.2
  P637:
    value: XP_016860272
    source count: 1
    confidence: 0.2
  P638:
    value: 3WWT
    source count: 1
    confidence: 0.2
  P638:
    value: 1BF5
    source count: 1
    confidence: 0.2
  P638:
    value: 1YVL
    source count: 1
    confidence: 0.2

value: 2KA6
source count: 1
confidence: 0.2

value: D12.644.360.024.303.500.500
source count: 0
confidence: 0.0

value: D12.644.360.024.342.100
source count: 0
confidence: 0.0

value: D12.776.157.057.061.500.500
source count: 0
confidence: 0.0

value: D12.776.157.057.186.100
source count: 0
confidence: 0.0

value: D12.776.260.513.249.500
source count: 0
confidence: 0.0

value: Q14633858
source count: 3
confidence: 0.6
value label: DNA binding

value: Q14762996
source count: 2
confidence: 0.4
value label: protein homodimerization activity

value: Q14817979
source count: 3
confidence: 0.6
value label: DNA-binding transcription factor activity

value: Q54809672
source count: 1
confidence: 0.2
value label: RNA polymerase II general transcription initiation factor activity

value: Q14820643
source count: 1
confidence: 0.2
value label: signal transducer activity

value: Q79899
source count: 10
confidence: 1.0
value label: cytoplasm

value: Q14817956
source count: 2
confidence: 0.4
value label: nucleoplasm

value: Q30869
source count: 1
confidence: 0.2
value label: nucleolus

value: Q14330632
source count: 1
confidence: 0.2
value label: perinuclear region of cytoplasm

value: Q40260
source count: 11
confidence: 1.0
value label: nucleus

value: Q14633911
source count: 1
confidence: 0.2
value label: regulation of apoptotic process

value: Q14860018
source count: 1
confidence: 0.2
value label: metanephric mesenchymal cell proliferation involved in metanephros development

value: Q14633883
source count: 1
confidence: 0.2
value label: regulation of transcription, DNA-templated

value: Q14912026
source count: 1
confidence: 0.2
value label: cellular response to interferon-beta

value: Q14852032
source count: 1
confidence: 0.2
value label: regulation of transcription by RNA polymerase II

value: PBB GE STAT1 200887 s at fs.png
source count: 0
confidence: 0.0

value: Q14912030
source count: 1
confidence: 0.2
value label: STAT1

value: Q15978631
source count: 1
confidence: 0.2
value label: Homo sapiens

value: ENSP00000386244
source count: 1
confidence: 0.2

value: ENSP00000354394
source count: 1
confidence: 0.2

value: ENSP00000376136
source count: 1
confidence: 0.2

value: ENSP00000376137
source count: 1
confidence: 0.2

value: ENSP00000388240
source count: 1
confidence: 0.2

value: C0287920
source count: 1
confidence: 0.2

source: GOA
stated in qid: Q28018111
retrieved: 2019-05-09

source: Crystal structure of a tyrosine phosphorylated STAT-1 dimer bound to DNA
stated in qid: Q24336371
retrieved: 2019-05-09

source: Methyltransferase SETD2-Mediated Methylation of STAT1 Is Critical for Interferon Antiviral Activity
stated in qid: Q38696198
retrieved: 2019-05-09

source: Nucleocytoplasmic translocation of Stat1 is regulated by a leucine-rich export signal in the coiled-coil domain
stated in qid: Q24290190
retrieved: 2019-05-09

source: hCAF1/CNOT7 regulates interferon signalling by targeting STAT1.
stated in qid: Q30032665
retrieved: 2019-05-09

source: Methyltransferase SETD2-Mediated Methylation of STAT1 Is Critical for Interferon Antiviral Activity
stated in qid: Q38696198
retrieved: 2018-03-27

source: GOA
stated in qid: Q28018111
retrieved: 2018-03-27

source: Regulation of XAF1 expression in human colon cancer cell by interferon beta: activation by the transcription regulator STAT1
stated in qid: Q24301327
retrieved: 2019-04-08

source: Molecular mechanisms underlying the inhibition of IFN-γ-induced, STAT1-mediated gene transcription in human macrophages by simvastatin and agonists of PPARs and LXRs
stated in qid: Q24338459
retrieved: 2019-04-08

source: Tid1 isoforms are mitochondrial DnaJ-like chaperones with unique carboxyl termini that determine cytosolic fate
stated in qid: Q24307669
retrieved: 2019-05-09

source: The cell death regulator GRIM-19 is an inhibitor of signal transducer and activator of transcription 3
stated in qid: Q24309232
retrieved: 2019-05-09

source: PARP9-DTX3L ubiquitin ligase targets host histone H2BJ and viral 3C protease to enhance interferon signaling and control viral infection
stated in qid: Q36299937
retrieved: 2019-05-09

source: Respiratory syncytial virus-inducible BCL-3 expression antagonizes the STAT/IRF and NF-kappaB signaling pathways by inducing histone deacetylase 1 recruitment to the interleukin-8 promoter
stated in qid: Q24296927
retrieved: 2019-05-09

source: Reactive Oxygen Species (ROS) Mediate p300-dependent STAT1 Protein Interaction with Peroxisome Proliferator-activated Receptor (PPAR)-γ in CD36 Protein Expression and Foam Cell Formation
stated in qid: Q28115789
retrieved: 2019-05-09

source: Stat1 as a component of tumor necrosis factor alpha receptor 1-TRADD signaling complex to inhibit NF-kappaB activation
stated in qid: Q22254226
retrieved: 2019-05-09

source: Structural bases of unphosphorylated STAT1 association and receptor binding
stated in qid: Q24298555
retrieved: 2019-05-09

source: A quantitative protein interaction network for the ErbB receptors using protein microarrays
stated in qid: Q24293746
retrieved: 2019-05-09

source: A proteome-scale map of the human interactome network
stated in qid: Q24307146
retrieved: 2019-05-09

source: The SH2 domains of Stat1 and Stat2 mediate multiple interactions in the transduction of IFN-alpha signals
stated in qid: Q24323741
retrieved: 2019-05-09

source: Mapping a dynamic innate immunity protein interaction network regulating type I interferon production
stated in qid: Q24337463
retrieved: 2019-05-09

source: VP8, the Major Tegument Protein of Bovine Herpesvirus 1, Interacts with Cellular STAT1 and Inhibits Interferon Beta Signaling
stated in qid: Q28115701
retrieved: 2019-05-09

source: PIPINO: A Software Package to Facilitate the Identification of Protein-Protein Interactions from Affinity Purification Mass Spectrometry Data
stated in qid: Q31056803
retrieved: 2019-05-09

source: Hepatitis C virus expression suppresses interferon signaling by degrading STAT1
stated in qid: Q24300002
retrieved: 2019-05-09

source: A Comprehensive Resource of Interacting Protein Regions for Refining Human Transcription Factor Networks
stated in qid: Q21091144
retrieved: 2019-05-09

source: Identification of both positive and negative domains within the epidermal growth factor receptor COOH-terminal region for signal transducer and activator of transcription (STAT) activation
stated in qid: Q24299920
retrieved: 2019-05-09

source: Hepatitis C virus core protein blocks interferon signaling by interaction with the STAT1 SH2 domain
stated in qid: Q24301056
retrieved: 2019-05-09

source: Functional subdomains of STAT2 required for preassociation with the alpha interferon receptor and for signaling
stated in qid: Q24646686
retrieved: 2019-05-09

source: Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes
stated in qid: Q28115646
retrieved: 2019-05-09

source: Direct suppression of Stat1 function during adenoviral infection
stated in qid: Q22008641
retrieved: 2019-05-09

source: Ligand-induced IFN gamma receptor tyrosine phosphorylation couples the receptor to its signal transduction system (p91)
stated in qid: Q24310595
retrieved: 2019-05-09

wikidata id: Q7394687
domain: protein
level: standard
html url: https://4ort.xyz/entity/signal-transducer-and-activator-of-transcription-1
markdown url: https://4ort.xyz/entity/signal-transducer-and-activator-of-transcription-1.md
facts url summary: https://4ort.xyz/entity/signal-transducer-and-activator-of-transcription-1/facts.json
facts url standard: https://4ort.xyz/entity/signal-transducer-and-activator-of-transcription-1/facts.json
facts url full: https://4ort.xyz/entity/signal-transducer-and-activator-of-transcription-1/facts.json
data source: Wikidata (CC0 / public domain)
license: https://creativecommons.org/publicdomain/zero/1.0/
api version: v1
served at: 2026-08-06T13:38:39.852140Z
entity updated at: 2026-05-03T18:28:36.114423+00:00Z
entity created at: 2026-05-03T14:53:56.844543+00:00Z