# Signal transducer and activator of transcription 1

> mammalian protein found in Homo sapiens

**Wikidata**: [Q7394687](https://www.wikidata.org/wiki/Q7394687)  
**Source**: https://4ort.xyz/entity/signal-transducer-and-activator-of-transcription-1


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P42224)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224)
5. [Crystal structure of a tyrosine phosphorylated STAT-1 dimer bound to DNA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224)
6. [Methyltransferase SETD2-Mediated Methylation of STAT1 Is Critical for Interferon Antiviral Activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224)
7. [Nucleocytoplasmic translocation of Stat1 is regulated by a leucine-rich export signal in the coiled-coil domain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224)
8. [hCAF1/CNOT7 regulates interferon signalling by targeting STAT1.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224)
9. [Methyltransferase SETD2-Mediated Methylation of STAT1 Is Critical for Interferon Antiviral Activity](http://www.ebi.ac.uk/QuickGO/annotations?protein=P42224&geneProductId=UniProtKB:P42224)
10. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P42224&geneProductId=UniProtKB:P42224)
11. [Regulation of XAF1 expression in human colon cancer cell by interferon beta: activation by the transcription regulator STAT1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224)
12. [Molecular mechanisms underlying the inhibition of IFN-γ-induced, STAT1-mediated gene transcription in human macrophages by simvastatin and agonists of PPARs and LXRs](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224)
13. [Tid1 isoforms are mitochondrial DnaJ-like chaperones with unique carboxyl termini that determine cytosolic fate](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224)
14. [The cell death regulator GRIM-19 is an inhibitor of signal transducer and activator of transcription 3](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224)
15. [PARP9-DTX3L ubiquitin ligase targets host histone H2BJ and viral 3C protease to enhance interferon signaling and control viral infection](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224)
16. [Respiratory syncytial virus-inducible BCL-3 expression antagonizes the STAT/IRF and NF-kappaB signaling pathways by inducing histone deacetylase 1 recruitment to the interleukin-8 promoter](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224)
17. [Reactive Oxygen Species (ROS) Mediate p300-dependent STAT1 Protein Interaction with Peroxisome Proliferator-activated Receptor (PPAR)-γ in CD36 Protein Expression and Foam Cell Formation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224)
18. [Stat1 as a component of tumor necrosis factor alpha receptor 1-TRADD signaling complex to inhibit NF-kappaB activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224)
19. [Structural bases of unphosphorylated STAT1 association and receptor binding](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224)
20. [A quantitative protein interaction network for the ErbB receptors using protein microarrays](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224)
21. [A proteome-scale map of the human interactome network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224)
22. [The SH2 domains of Stat1 and Stat2 mediate multiple interactions in the transduction of IFN-alpha signals](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224)
23. [Mapping a dynamic innate immunity protein interaction network regulating type I interferon production](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224)
24. [VP8, the Major Tegument Protein of Bovine Herpesvirus 1, Interacts with Cellular STAT1 and Inhibits Interferon Beta Signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224)
25. [PIPINO: A Software Package to Facilitate the Identification of Protein-Protein Interactions from Affinity Purification Mass Spectrometry Data](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224)
26. [Hepatitis C virus expression suppresses interferon signaling by degrading STAT1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224)
27. [A Comprehensive Resource of Interacting Protein Regions for Refining Human Transcription Factor Networks](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224)
28. [Identification of both positive and negative domains within the epidermal growth factor receptor COOH-terminal region for signal transducer and activator of transcription (STAT) activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224)
29. [Hepatitis C virus core protein blocks interferon signaling by interaction with the STAT1 SH2 domain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224)
30. [Functional subdomains of STAT2 required for preassociation with the alpha interferon receptor and for signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224)
31. [Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224)
32. [Direct suppression of Stat1 function during adenoviral infection](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224)
33. [Ligand-induced IFN gamma receptor tyrosine phosphorylation couples the receptor to its signal transduction system (p91)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224)
34. [IFNβ-dependent increases in STAT1, STAT2, and IRF9 mediate resistance to viruses and DNA damage](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224)
35. [The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224)
36. [STAT-1 and c-Fos interaction in nitric oxide synthase-2 gene activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224)
37. [Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein–Protein Interactions in a Pathway Network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224)
38. [Vaccinia virus blocks gamma interferon signal transduction: viral VH1 phosphatase reverses Stat1 activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224)
39. [Differential activation of acute phase response factor/STAT3 and STAT1 via the cytoplasmic domain of the interleukin 6 signal transducer gp130. I. Definition of a novel phosphotyrosine motif mediating STAT1 activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224)
40. [Hepatic RIG-I predicts survival and interferon-α therapeutic response in hepatocellular carcinoma](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224)
41. [Toward an understanding of the protein interaction network of the human liver](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224)
42. [HCV NS5A inhibits interferon-alpha signaling through suppression of STAT1 phosphorylation in hepatocyte-derived cell lines](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224)
43. [Towards a proteome-scale map of the human protein–protein interaction network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224)
44. [Acetylation-dependent signal transduction for type I interferon receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224)
45. [A Novel Disrupter of Telomere Silencing 1-like (DOT1L) Interaction Is Required for Signal Transducer and Activator of Transcription 1 (STAT1)-activated Gene Expression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224)
46. [E-cadherin interactome complexity and robustness resolved by quantitative proteomics](http://www.ebi.ac.uk/QuickGO/annotations?protein=P42224&geneProductId=UniProtKB:P42224)
47. [A census of human transcription factors: function, expression and evolution](http://www.ebi.ac.uk/QuickGO/annotations?protein=P42224&geneProductId=UniProtKB:P42224)
48. [Molecular mechanisms underlying the inhibition of IFN-γ-induced, STAT1-mediated gene transcription in human macrophages by simvastatin and agonists of PPARs and LXRs](http://www.ebi.ac.uk/QuickGO/annotations?protein=P42224&geneProductId=UniProtKB:P42224)
49. [A census of human transcription factors: function, expression and evolution](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224)
50. [E-cadherin interactome complexity and robustness resolved by quantitative proteomics](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42224)