# Signal peptide peptidase like 3

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21122091](https://www.wikidata.org/wiki/Q21122091)  
**Source**: https://4ort.xyz/entity/signal-peptide-peptidase-like-3


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q8TCT6)
3. Q20641742
4. [Differential Localization and Identification of a Critical Aspartate Suggest Non-redundant Proteolytic Functions of the Presenilin Homologues SPPL2b and SPPL3](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT6)
5. [Consensus Analysis of Signal Peptide Peptidase and Homologous Human Aspartic Proteases Reveals Opposite Topology of Catalytic Domains Compared with Presenilins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT6)
6. [Intramembrane proteolytic cleavage by human signal peptide peptidase like 3 and malaria signal peptide peptidase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT6)
7. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT6)
8. [Intramembrane proteolytic cleavage by human signal peptide peptidase like 3 and malaria signal peptide peptidase](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8TCT6&geneProductId=UniProtKB:Q8TCT6)
9. [In Vivo Measurements of Ethanol Concentration in Rabbit Brain by 1H Magnetic Resonance Spectroscopy](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8TCT6&geneProductId=UniProtKB:Q8TCT6)
10. [In Vivo Measurements of Ethanol Concentration in Rabbit Brain by 1H Magnetic Resonance Spectroscopy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT6)
11. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT6)
12. [Consensus Analysis of Signal Peptide Peptidase and Homologous Human Aspartic Proteases Reveals Opposite Topology of Catalytic Domains Compared with Presenilins](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8TCT6&geneProductId=UniProtKB:Q8TCT6)
13. [SPPL2a and SPPL2b promote intramembrane proteolysis of TNFα in activated dendritic cells to trigger IL-12 production](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8TCT6&geneProductId=UniProtKB:Q8TCT6)
14. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8TCT6&geneProductId=UniProtKB:Q8TCT6)
15. [SPPL2a and SPPL2b promote intramembrane proteolysis of TNFα in activated dendritic cells to trigger IL-12 production](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT6)
16. [A Protease-Independent Function for SPPL3 in NFAT Activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT6)
17. [Regulated Intramembrane Proteolysis of Bri2 (Itm2b) by ADAM10 and SPPL2a/SPPL2b](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT6)
18. Ensembl Release 99