# Signal peptide peptidase like 2B

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21122092](https://www.wikidata.org/wiki/Q21122092)  
**Source**: https://4ort.xyz/entity/signal-peptide-peptidase-like-2b


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q8TCT7)
3. Q20641742
4. [Differential Localization and Identification of a Critical Aspartate Suggest Non-redundant Proteolytic Functions of the Presenilin Homologues SPPL2b and SPPL3](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT7)
5. [Consensus Analysis of Signal Peptide Peptidase and Homologous Human Aspartic Proteases Reveals Opposite Topology of Catalytic Domains Compared with Presenilins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT7)
6. [Intramembrane proteolytic cleavage by human signal peptide peptidase like 3 and malaria signal peptide peptidase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT7)
7. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT7)
8. [Regulated Intramembrane Proteolysis of Bri2 (Itm2b) by ADAM10 and SPPL2a/SPPL2b](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT7)
9. [In Vivo Measurements of Ethanol Concentration in Rabbit Brain by 1H Magnetic Resonance Spectroscopy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT7)
10. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8TCT7&geneProductId=UniProtKB:Q8TCT7)
11. [The α-Helical Content of the Transmembrane Domain of the British Dementia Protein-2 (Bri2) Determines Its Processing by Signal Peptide Peptidase-like 2b (SPPL2b)](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8TCT7&geneProductId=UniProtKB:Q8TCT7)
12. [Substrate Requirements for SPPL2b-dependent Regulated Intramembrane Proteolysis](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8TCT7&geneProductId=UniProtKB:Q8TCT7)
13. [Intramembrane proteolytic cleavage by human signal peptide peptidase like 3 and malaria signal peptide peptidase](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8TCT7&geneProductId=UniProtKB:Q8TCT7)
14. [In Vivo Measurements of Ethanol Concentration in Rabbit Brain by 1H Magnetic Resonance Spectroscopy](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8TCT7&geneProductId=UniProtKB:Q8TCT7)
15. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8TCT7&geneProductId=UniProtKB:Q8TCT7)
16. [The α-Helical Content of the Transmembrane Domain of the British Dementia Protein-2 (Bri2) Determines Its Processing by Signal Peptide Peptidase-like 2b (SPPL2b)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT7)
17. [Substrate Requirements for SPPL2b-dependent Regulated Intramembrane Proteolysis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT7)
18. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT7)
19. [Consensus Analysis of Signal Peptide Peptidase and Homologous Human Aspartic Proteases Reveals Opposite Topology of Catalytic Domains Compared with Presenilins](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8TCT7&geneProductId=UniProtKB:Q8TCT7)
20. [Differential Localization and Identification of a Critical Aspartate Suggest Non-redundant Proteolytic Functions of the Presenilin Homologues SPPL2b and SPPL3](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8TCT7&geneProductId=UniProtKB:Q8TCT7)
21. [Regulated Intramembrane Proteolysis of Bri2 (Itm2b) by ADAM10 and SPPL2a/SPPL2b](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8TCT7&geneProductId=UniProtKB:Q8TCT7)
22. [SPPL2a and SPPL2b promote intramembrane proteolysis of TNFα in activated dendritic cells to trigger IL-12 production](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT7)
23. [Signal-peptide-peptidase-like 2a (SPPL2a) is targeted to lysosomes/late endosomes by a tyrosine motif in its C-terminal tail](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT7)
24. [A γ-secretase-like intramembrane cleavage of TNFα by the GxGD aspartyl protease SPPL2b](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT7)
25. Ensembl Release 99