# Signal peptide peptidase like 2A

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21126381](https://www.wikidata.org/wiki/Q21126381)  
**Source**: https://4ort.xyz/entity/signal-peptide-peptidase-like-2a


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q8TCT8)
3. Q20641742
4. [Consensus analysis of signal peptide peptidase and homologous human aspartic proteases reveals opposite topology of catalytic domains compared with presenilins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT8)
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT8)
6. [Regulated intramembrane proteolysis of Bri2 (Itm2b) by ADAM10 and SPPL2a/SPPL2b](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT8)
7. [A proteome-scale map of the human interactome network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT8)
8. [Towards a proteome-scale map of the human protein–protein interaction network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT8)
9. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8TCT8&geneProductId=UniProtKB:Q8TCT8)
10. [In vivo measurements of ethanol concentration in rabbit brain by 1H magnetic resonance spectroscopy](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8TCT8&geneProductId=UniProtKB:Q8TCT8)
11. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8TCT8&geneProductId=UniProtKB:Q8TCT8)
12. [In vivo measurements of ethanol concentration in rabbit brain by 1H magnetic resonance spectroscopy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT8)
13. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT8)
14. [SPPL2a and SPPL2b promote intramembrane proteolysis of TNFalpha in activated dendritic cells to trigger IL-12 production](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT8)
15. [Consensus analysis of signal peptide peptidase and homologous human aspartic proteases reveals opposite topology of catalytic domains compared with presenilins](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8TCT8&geneProductId=UniProtKB:Q8TCT8)
16. [Integral and associated lysosomal membrane proteins](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8TCT8&geneProductId=UniProtKB:Q8TCT8)
17. [Regulated intramembrane proteolysis of Bri2 (Itm2b) by ADAM10 and SPPL2a/SPPL2b](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8TCT8&geneProductId=UniProtKB:Q8TCT8)
18. [In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8TCT8&geneProductId=UniProtKB:Q8TCT8)
19. [Integral and associated lysosomal membrane proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT8)
20. [In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT8)
21. [A gamma-secretase-like intramembrane cleavage of TNFalpha by the GxGD aspartyl protease SPPL2b](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT8)
22. [The Fas ligand intracellular domain is released by ADAM10 and SPPL2a cleavage in T-cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT8)
23. Ensembl Release 99
24. Transporter Classification database